scholarly journals A Triple Helix systems perspective of UK drug discovery and development: A systematic review of REF impact case studies

2020 ◽  
pp. 095042222096934
Author(s):  
Leonard Kelleher ◽  
Anna Zecharia
Keyword(s):  
Drug Discovery ◽  
Case Studies ◽  
Strategic Alliances ◽  
Triple Helix ◽  
Systems Approach ◽  
Research Policy ◽  
Empirical Studies ◽  
Innovation System ◽  
Theory Development ◽  
Drug Discovery And Development

UK drug discovery and development is increasingly being shaped through a complex interaction of research, policy and practice. However, our understanding of this innovation system is partially due to the dearth of systems-level empirical studies and to simplistic conceptual approaches. This study uses a Triple Helix systems approach to illustrate how a novel database of Research Excellence Framework 2014 impact case studies may be used both to advance empirical understanding of UK drug discovery and development and for theory development. The authors refine the Triple Helix system by identifying relationships between its three components (academia, government and industry) and various social actors. The paper also make two contributions to practice, concerning the relative unimportance for impact generation of geographical clusters relative to strategic alliances, network linkages and knowledge spillovers, and the strong bias towards national and Anglo-American academic–practitioner linkages with few or no links to emerging knowledge economies.

Building Theories for Hospitality Discipline: An Attempt to Describe and Elaborate Required Processes and Procedures

2019 ◽  
Vol 43 (5) ◽  
pp. 619-632 ◽  
Author(s):  
Mahmood A. Khan
Keyword(s):  
Case Studies ◽  
Empirical Studies ◽  
Theory Development ◽  
Theory Formation

Considering the need, the primary intent of this study is to spur contemplation related to building theories that specifically pertain to the hospitality discipline. A review of process required for theory formation is preceded with a description related to (a) developing grounded theories using empirical studies and (b) using case studies for theory development. As an outcome of the discussion, steps necessary for theory development are listed and described. Finally, as a test, properties that are vital for a strong theory are provided as a checklist.

Biotech–pharma alliances: Strategies, structures and financing

10.5912/jcb91 ◽  
2004 ◽  
Vol 10 (4) ◽  
Author(s):  
Tyzoon Tyebjee ◽  
Jill Hardin
Keyword(s):  
Drug Discovery ◽  
Case Studies ◽  
Financial Instruments ◽  
Drug Discovery And Development ◽  
Development Cycle ◽  
Biotechnology Companies ◽  
Strategic Logic

The drug discovery and development industry is under intense pressure to become more efficient and develop drugs better, faster, cheaper. Consequently, pharmaceutical and biotechnology companies are entering into alliances in an effort to utilise each other's talents, exploit each other's specialisations, and create more value. In this paper, the economics of the drug discovery and development cycle are examined to identify the economic and strategic logic of the alliances. The financial instruments commonly used to structure the alliances are discussed with example case studies.

“Triple Helix” in Russia’s Innovation System

2007 ◽  
pp. 123-135 ◽  
Author(s):  
I. Dezhina ◽  
V. Kiseleva
Keyword(s):  
Triple Helix ◽  
Government Regulation ◽  
Innovation System ◽  
Innovation Systems ◽  
Modern Theory

The article analyzes modern theory that explains the specificity of relationships among government, science and business in innovation systems - the "triple helix" concept. Factors that determine the appearance of new theory are systematized. The peculiarities of formation of "triple helix" in Russia are described, including the development of science, business and the system of government regulation in innovation sphere. The conclusion is made that currently in Russia only double linkages are formed.

Factors influencing the structure of the Russian companies' capital

2020 ◽  
Vol 26 (7) ◽  
pp. 1647-1660
Author(s):  
O.N. Likhacheva ◽  
A.S. Belikevich
Keyword(s):  
Correlation Analysis ◽  
Capital Structure ◽  
Systems Approach ◽  
Empirical Studies ◽  
Factors Influencing ◽  
Oil Contracts ◽  
Economic Landscape ◽  
Relationship Of ◽  
Trade Wars ◽  
The Capital Structure

Subject. In the uncertain market environment, the optimal structure of capital is getting more important because it influences the competitiveness of a firm, its financial sustainability and solvency and, consequently, a success. Herein we dwell upon the hypothesis presuming the existence of capital structure determinants. Objectives. We review empirical studies on the subject, analyze determinants of the Russian companies’ capital structure. Methods. The study is based on the systems approach and methods of statistical analysis. Results. It is necessary to monitor how capital is shaped and formed. We investigated proceedings on factors influencing the capital structure and discovered relevant hypotheses, carrying out the correlation analysis of such factors. Conclusions and Relevance. It is especially important to examine factors influencing the capital structure, and find the appropriate format for the economy struggling through the crisis. The coronavirus pandemic unavoidably reshapes the global economic landscape, which has already been under the pressure of deglobalization processes (trade wars, repudiation of oil contracts). The correlation analysis did not reveal any relationship of the variables in question (the company’s age, ROE, ROA, MOEX, key rate, GDP, PPI) and the capital structure. Further research should be devoted to other factors and consider the unreasonableness and psychological background of managers’ behavior who make decisions concerning the capital structure.

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