Chemical gastro-oesophagitis, upper gastrointestinal haemorrhage and gastroscopic findings following Dettol poisoning

1 Dettol liquid (chloroxylenol 4.8%, pine oil, isopropyl alcohol), a household disinfectant, has a corrosive action on the gastrointestinal mucosa when swallowed. The inci dence of upper gastrointestinal haemorrhage and gastro scopic findings following Dettol poisoning was studied in 89 patients. 2 Five patients (5.6%) developed minor haematemesis, in the form of coffee-coloured or blood-stained vomitus. One patient had a gastroscopy performed on the day after admission, showing signs of chemical burns in the oesoph agus and stomach. Gastroscopy was performed in one other patient on day 11 to rule out oesophageal stricture; the patient was normal. All patients completely recovered. 3 The data from this study suggest that upper gastroin testinal haemorrhage following Dettol poisoning tends to be mild and self-limiting. Gastroscopy, which may increase the risk of aspiration in patients with impaired consciousness, is not required unless other causes of gas trointestinal bleeding are suspected.

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UPPER GASTROINTESTINAL HAEMORRHAGE‐**A REVIEW OF 100 CASES

The Medical Journal of Australia ◽

10.5694/j.1326-5377.1976.tb140583.x ◽

1962 ◽

Vol 1 (9) ◽

pp. 253-256 ◽

Cited By ~ 1

Author(s):

MICHAEL W. LANIGAN

Keyword(s):

Gastrointestinal Haemorrhage ◽

Upper Gastrointestinal

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THE EFFECT OF EARLY BLOOD TRANSFUSION ON THE OUTCOME OF GASTROINTESTINAL HAEMORRHAGE

10.1055/s-0038-1644157 ◽

1987 ◽

Author(s):

S D Blair ◽

S B Javanvrin ◽

C N McCollum ◽

R M Greenhalgh

Keyword(s):

Blood Transfusion ◽

Blood Coagulation ◽

Whole Blood ◽

Randomised Trial ◽

Gastrointestinal Haemorrhage ◽

Clotting Time ◽

Prospective Randomised Trial ◽

Coagulation Tests ◽

To Receive ◽

Upper Gastrointestinal

It has been suggested that mortality due to upper gastrointestinal haemorrhage may be reduced by restricting blood transfusion [1], We have assessed whether this is due to an anticoagulant effect in a prospective randomised trial.One hundred patients with severe, acute gastrointestinal haemorrhage were randomised to receive either at least 2 units of blood during the first 24 hours of admission, or no blood unless their haemaglobin was lessthan 8g/dl or they were shocked. Minor bleeds and varices were excluded As hypercoagulation cannot be measured using conventional coagulation tests, fresh whole blood coagulation was measured by the Biobridge Impedance Clotting Time (ICT). Coagulation was assessed at 24 hour intervals and compared to age matched controls with the results expressed as mean ± sem.The ICT on admission for the transfusion group (n=50) was 3.2±0.2 mins compared to 10±0.2 mins in controls. This hyper-coagulable state was partially reversed to 6.4±0.3 mins at 24 hours (p<0.001). The 50 allocated to receive no blood had a similar ICT on admission of 4.4±0.4 mins but the hypercoagulable state was maintained with ICT at 24 hours of 4.320.4 mins. Only 2 patients not transfused rebled compared to 15 in the early transfusion group (p<0.001). Five patients died, and they were all in the early transfusion group.These findings show there is a hypercoagulable response to haemorrhage which is partially reversed by blood transfusion leading to rebleeding

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W14859 safely heals upper gastrointestinal haemorrhage

Inpharma Weekly ◽

10.2165/00128413-199007200-00044 ◽

1990 ◽

Vol &NA; (720) ◽

pp. 16

Author(s):

&NA;

Keyword(s):

Gastrointestinal Haemorrhage ◽

Upper Gastrointestinal

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The risk of aspiration in Dettol poisoning: a retrospective cohort study

Human & Experimental Toxicology ◽

10.1177/096032719501400206 ◽

1995 ◽

Vol 14 (2) ◽

pp. 190-191 ◽

Cited By ~ 3

Author(s):

Thomas Y.K. Chan ◽

Julian A.J.H. Critchley ◽

Joseph T.F. Lau

Keyword(s):

Retrospective Cohort ◽

Matched Control ◽

Gastric Lavage ◽

Common Occurrence ◽

Pine Oil ◽

Control Subjects ◽

Increased Risk ◽

The Common ◽

Risk Of Aspiration ◽

Increase In Risk

1 To determine if the risk of aspiration is increased in 'Dettol' (4.8% chloroxylenol, pine oil and isopropyl alco hol) poisoning and the factors that may be responsible, a study was made of 89 patients and 89 matched control subjects with other forms of poisoning admitted to the Prince of Wales Hospital, Hong Kong. 2 Aspiration was more common in patients with Dettol poisoning (8% vs 3%, P = 0.16). There were more control subjects with drowsiness at presentation (54% vs 24%, P < 0.0001), but the use of gastric lavage (88% vs 64%, P < 0.001) and the occurrence of vomiting (62% vs 17%, P < 0.0001) were more common in patients with Dettol poisoning. 3 Our findings suggest that Dettol poisoning may be asso ciated with an increased risk of aspiration. This increase in risk may be related to the use of gastric lavage and the common occurrence of vomiting in patients with Dettol poisoning.

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