Distribution of Antibody Titers to Bovine Viral Diarrhea Virus in Infected, Exposed, and Uninfected Beef Cattle

Two 8-month reindeer (<em>Rangifer tarandus</em>) and a 1-month-old Hereford-Holstein calf (<em>Bos taurus</em>) were inoculated intranasally with the Singer (cytopathogenic) strain of bovine viral diarrhea (BVD) virus. Clinical signs in reindeer included loose stools containing blood and mucus, and transient laminitis or coronitis. Signs in the calf were limited to bloody mucus in the stool and lesions in the nasal mucosa. Antibody titers to BVD virus in the reindeer were intermittent, and titers in the calf persisted from days 14 to 63 post-inoculation (PI). Viremia was detected on PI day 4 in one reindeer, days 3-7 in the other, and days 2-7 in the calf. Bovine viral diarrhea virus was isolated from the lung of the calf at necropsy (PI day 63).

Download Full-text

Contribution of Leptospira, Neospora caninum and bovine viral diarrhea virus to fetal loss of beef cattle in New Zealand

Preventive Veterinary Medicine ◽

10.1016/j.prevetmed.2013.07.009 ◽

2013 ◽

Vol 112 (1-2) ◽

pp. 90-98 ◽

Cited By ~ 20

Author(s):

J.M. Sanhueza ◽

C. Heuer ◽

D. West

Keyword(s):

New Zealand ◽

Beef Cattle ◽

Bovine Viral Diarrhea Virus ◽

Neospora Caninum ◽

Fetal Loss ◽

Bovine Viral Diarrhea ◽

Diarrhea Virus ◽

Viral Diarrhea ◽

Viral Diarrhea Virus

Download Full-text

Prevalence of Cattle Persistently Infected with Bovine Viral Diarrhea Virus in 20 Dairy Herds in Two Counties in Central Michigan and Comparison of Prevalence of Antibody-Positive Cattle among Herds with Different Infection and Vaccination Status

Journal of Veterinary Diagnostic Investigation ◽

10.1177/104063879500700304 ◽

1995 ◽

Vol 7 (3) ◽

pp. 321-326 ◽

Cited By ~ 56

Author(s):

H. Houe ◽

J. C. Baker ◽

R. K. Maes ◽

H. Wuryastuti ◽

R. Wasito ◽

...

Keyword(s):

Bovine Viral Diarrhea Virus ◽

Dairy Herd ◽

Vaccination Status ◽

Bovine Viral Diarrhea ◽

Dairy Herds ◽

Persistently Infected ◽

Diarrhea Virus ◽

Viral Diarrhea ◽

Antibody Titers ◽

Viral Diarrhea Virus

All cattle in 20 dairy herds randomly selected from herds participating in the Dairy Herd Improvement Association program in 2 counties in central Michigan were tested for the presence of bovine viral diarrhea virus (BVDV). Virus-positive animals were retested to ascertain persistent infection with the virus. A total of 5,481 animals were tested for presence of BVDV. In 9 of the herds, all animals were also tested for virus neutralizing antibody titer. Based on infection and vaccination status, these 9 herds were divided into 3 different herd categories: A, 5 herds with currently no cattle persistently infected (PI) with BVDV and without any vaccination program against BVDV in recent years; B, 2 herds with no current PI cattle but using killed BVDV vaccines; and C, 2 herds with PI cattle. PI cattle were detected in 3 out of 20 herds (15%). A total of 7 of 5,481 animals (0.13%) were PI. The mean prevalences of antibody carriers in herd categories A, B, and C were 28.8%, 76.4% and 90.6%, respectively. For one herd in category A, antibody analyses indicated that mostly young stock was seropositive, suggested recent BVDV infection in a previously closed and naive herd. Cattle in category B herds were vaccinated with killed vaccine from the age of 15 months. These herds had several antibody negative animals among the younger cows, suggesting incomplete protection against BVDV infection. In the 3 herds in which PI animals were detected, all cattle had been vaccinated with killed vaccine. The antibody-positive animals had antibody titers that were significantly different both among herds and among herd categories. The antibody titers of animals exposed to PI animals were significantly higher than those of animals vaccinated with killed vaccine.

Download Full-text

Virulent Properties of Russian Bovine Viral Diarrhea Virus Strains in Experimentally Infected Calves

Scientifica ◽

10.1155/2016/7034509 ◽

2016 ◽

Vol 2016 ◽

pp. 1-9 ◽

Cited By ~ 1

Author(s):

Alexander G. Glotov ◽

Tatyana I. Glotova ◽

Svetlana V. Koteneva ◽

Olga V. Semenova ◽

Alexander A. Sergeev ◽

...

Keyword(s):

Bovine Viral Diarrhea Virus ◽

Bovine Viral Diarrhea ◽

Diagnostic Systems ◽

Diarrhea Virus ◽

Viral Diarrhea ◽

Control Programs ◽

Humoral Immune ◽

Antibody Titers ◽

Viral Diarrhea Virus

The results of experimental study of three noncytopathic and two cytopathic bovine viral diarrhea virus (BVDV) strains isolated from cattle in the Siberian region and belonging to the type 1 (subtypes 1a, 1b, and 1d) have been presented. All investigated strains caused the development of infectious process in the seronegative 4–6-month-old calves after aerosol challenge with the dose of 6 log10TCID50. The greatest virulence had noncytopathic strain and cytopathic strain related to the subtypes 1d and 1b, respectively. All strains in infected calves caused some signs of moderate acute respiratory disease and diarrhea: depression 3–5 days postinfection (p.i.), refusal to food, severe hyperthermia to 41.9°С, serous exudate discharges from the nasal cavity and eyes, transient diarrhea with blood, leukopenia (up to 2700 cells/mm3), and macroscopic changes in the respiratory organs and intestine. The infected animals recovered from 12 to 15 days p.i. and in 90% cases formed humoral immune response 25 days p.i. (antibody titers to BVDV: 1 : 4–1 : 16). Our results confirmed the presence of virulent BVDV1 strains and showed the need for researches on the molecular epidemiology of the disease, development of more effective diagnostic systems, and optimization of control programs with use of vaccines.

Download Full-text