Filtering Out Use of DOACs in Hemodialysis

2017 ◽  
Vol 51 (6) ◽  
pp. 511-513 ◽  
Author(s):  
William E. Dager ◽  
Jin A. Lee
Keyword(s):  
Clinical Trials ◽  
Oral Anticoagulants ◽  
Published Data ◽  
Supporting Evidence ◽  
Thrombosis Risk ◽  
Risk Identify ◽  
Renal Support Therapy ◽  
Direct Acting ◽  
Direct Acting Oral Anticoagulants ◽  
Renal Support

Published data exploring the best approach to initiating and maintaining anticoagulation in the setting of renal support therapy are scarce, as these patients were excluded in clinical trials. When developing an anticoagulation regimen in this setting, it is important to assess thrombosis risk, identify the unique drivers for thrombosis and bleeding, and recognize the limitations of supporting evidence behind approved prescribing indications for renal impairment. Available literature and considerations for using direct acting oral anticoagulants in the setting of renal support are reviewed.

Reversal of DIRECT-ACTING Oral Anticoagulants in Urgent Surgery of the Proximal Aorta: case Series and Review of the literature

2019 ◽  
Vol 24 (38) ◽  
pp. 4534-4539 ◽  
Author(s):  
Eric Zimmermann ◽  
Fawzi Ameer ◽  
Berhane Worku ◽  
Dimitrios Avgerinos
Keyword(s):  
Oral Anticoagulants ◽  
Aortic Surgery ◽  
Management Strategies ◽  
Case Series ◽  
Published Data ◽  
Review Of Literature ◽  
Clotting Factors ◽  
Urgent Surgery ◽  
Direct Acting ◽  
Direct Acting Oral Anticoagulants

Introduction: Proximal aorta interventions impose significant bleeding risk. Patients on concomitant anticoagulation regimens compound the risk of bleeding in any surgery, but especially cardiothoracic interventions. The employment of direct-acting oral anticoagulants (DOAC), namely those that target clotting factors II or X, has expanded at a precipitous rate over the last decade. The emergence of their reversal agents has followed slowly, leaving clinicians with management dilemmas in urgent surgery. We discuss current reversal strategies based on the available published data and our experience with proximal aortic surgery in patients taking DOACs. Literature Search: We performed a review of literature and present three cases from our experience to offer insight into management strategies that have been historically successful. A review of literature was conducted via PubMed with the following search string: (NOAC or DOAC or TSOAC) and (aorta or aortic or (Stanford and type and a)). Case Presentation: We present three case presentations that illustrate the importance of DOAC identification and offer management strategies in mitigating associated bleeding risks in urgent or emergent surgeries. Conclusion: Treatment teams should be aware of the technical limitations of identifying and reversing DOACs. In view of the tendency toward publishing positive outcomes, more scientific rigor is required in the area of emergency DOAC reversal strategies.

scholarly journals The use of direct acting oral anticoagulants in patients with COVID-19 infection

2021 ◽  
Vol 11 (2) ◽  
pp. 184-186
Author(s):  
Ragia Aly ◽  
Sachin Gupta ◽  
Balraj Singh ◽  
Parminder Kaur ◽  
Kunhwa Kim ◽  
...  
Keyword(s):  
Oral Anticoagulants ◽  
Direct Acting ◽  
Direct Acting Oral Anticoagulants

scholarly journals Anti–factor Xa activity assays of direct‐acting oral anticoagulants during clinical care: An observational study

2021 ◽  
Vol 5 (4) ◽  
Author(s):  
Smrithi Sukumar ◽  
Melissa Cabero ◽  
Sharon Tiu ◽  
Margaret C. Fang ◽  
Scott C. Kogan ◽  
...  
Keyword(s):  
Observational Study ◽  
Clinical Care ◽  
Oral Anticoagulants ◽  
Factor Xa ◽  
Direct Acting ◽  
Direct Acting Oral Anticoagulants

Direct-Acting Oral Anticoagulants in Critically Ill Patients

CHEST Journal ◽  
2019 ◽  
Vol 156 (3) ◽  
pp. 604-618 ◽  
Author(s):  
Parth Rali ◽  
Andrew Gangemi ◽  
Aimee Moores ◽  
Kerry Mohrien ◽  
Lisa Moores
Keyword(s):  
Critically Ill ◽  
Critically Ill Patients ◽  
Oral Anticoagulants ◽  
Direct Acting ◽  
Direct Acting Oral Anticoagulants

The risk of delayed intracranial hemorrhage with direct acting oral anticoagulants after trauma: A two-center study

2019 ◽  
Vol 217 (6) ◽  
pp. 1051-1054 ◽  
Author(s):  
Galinos Barmparas ◽  
Leslie Kobayashi ◽  
Navpreet K. Dhillon ◽  
Kavita A. Patel ◽  
Eric J. Ley ◽  
...  
Keyword(s):  
Intracranial Hemorrhage ◽  
Oral Anticoagulants ◽  
Direct Acting ◽  
Direct Acting Oral Anticoagulants ◽  
Center Study

scholarly journals Safety profile of outpatient diagnostic catheterization procedures in patients under direct-acting oral anticoagulants

2019 ◽  
Author(s):  
Cristina Ramírez Guijarro ◽  
Antonio Gutiérrez Díez ◽  
Juan Gabriel Córdoba Soriano ◽  
Arsenio Gallardo López ◽  
Driss Melehi El-Assali ◽  
...  
Keyword(s):  
Safety Profile ◽  
Oral Anticoagulants ◽  
Direct Acting ◽  
Direct Acting Oral Anticoagulants

scholarly journals Direct-acting oral anticoagulants in antiphospholipid syndrome

2021 ◽  
Vol 58 (6) ◽  
pp. 708-715
Author(s):  
T. M. Reshetnyak ◽  
K. S. Nurbaeva
Keyword(s):  
Antiphospholipid Syndrome ◽  
Oral Anticoagulants ◽  
Direct Acting ◽  
Direct Acting Oral Anticoagulants

Comparison of the HAS‐BLED versus ORBIT Scores in Predicting Major Bleeding Among Asians Receiving the Direct‐Acting Oral Anticoagulants

2021 ◽  
Author(s):  
Phannita Wattanaruengchai ◽  
Surakit Nathisuwan ◽  
Khemajira Karaketklang ◽  
Wanwarang Wongcharoen ◽  
Arintaya Phrommintikul ◽  
...  
Keyword(s):  
Major Bleeding ◽  
Oral Anticoagulants ◽  
Direct Acting ◽  
Direct Acting Oral Anticoagulants
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