Applied genomics in MPN presentation

Polycythemia vera, essential thrombocytosis (ET), and primary myelofibrosis (PMF) are grouped together as myeloproliferative neoplasms (MPNs) because of shared clinical, pathologic, and molecular features. The 2005 discovery of the driver mutation JAK2V617F, found in more than 70% of individuals with MPNs and 98% of those with PV, has transformed the diagnosis and management of MPNs. Although PV is the most common phenotype associated with JAK2V617F, roughly 60% of individuals with ET or PMF also have the mutation, and JAK2V617F is now recognized as a common lesion in clonal hematopoiesis (CH). JAK2V617F+ CH and MPN are indolent disorders that evolve over time, with transitions to different disease phases, transformation to bone marrow failure or leukemia, and high thrombosis rates. Genomic assessment has taken center stage as an important tool to define disease phenotype, disease burden, prognosis, and even thrombosis risk of MPNs. Genomics has also unveiled the causes and factors that modify the risk of acquiring and expanding CH and MPNs and points to new pathways for targeted therapies to treat and ultimately prevent them. Genomic assessment of patients with MPNs, like other cancers, enables the clinician to capitalize on large population data sets to inform the individual patient of risk, identify treatment, and improve outcomes.

Settlement Arrangement based on Landslide Risk Analysis in Girirejo, Bantul, Yogyakarta

<em>Located on a hilly topography with a steep slope, highlighted the importance of settlement arrangement based on a landslide risk assessment in Girirejo village, Imogiri, Bantul, Yogyakarta. This study aims to map landslides risk, identify houses in the landslide risk zone, and provide recommendations for settlement arrangements. The research begins with observation, interviews, and focus group discussion. Disaster risk mapping and analysis were carried out through weighting method based on Perka BNPB No.2 of 2012 concerning General Guidelines for Disaster Risk Assessment and a formula with parameters of hazard, vulnerability, and capacity. Results showed the medium to a high-level of landslide risk was dominated by northern and eastern parts of Girirejo (21 families in red-zone, 23 families in yellow-zone), while western and southern regions had a low landslide risk level. This research also provided a formulation of settlements concept for medium and high-risk areas by considering landslides risk analysis study.</em>

Identification of Influencing Factors: Does the Social Media Sites Affect the Education of College Students?

Probably we may come across the Social Media Sites (SMS) such as Facebook, WhatApp, Twitter and YouTube is a powerful media among the general public. The recent days without social media noting do to so for that reason every individual could be an account holder of social media. With the impact of social media, we could make significant changes among the public or government. The objective of the study is to find out the most influenced factor in Social Media Sites (SMS) among college students. Seven factors are used for the study such as Privacy_F1, Friendship_F2, Illegal Problems_F3, Advertise _F4, Risk Identify _F5, Easiest Share_F6, Post_ F7. Privacy F1 is the most influenced factor among the college students

Research on Construction Risk Control of International Project

From the perspective of China’s construction enterprises, taking the nature of risk and engineering’s characteristics into account. The paper apply the Delphi Method to establish primeval list of international project construction risk, use Analytic Hierarchy Process to conduct a comprehensive evaluation to risk factors in the primeval list of international project construction risk, identify risk factors and put forward coping strategies, The ultimate goal is to provide reference and a basis for risk management of construction companies involved in international project construction.

Prognostic and Predictive biomarkers in a Mediterranean cohort (Review from Atena Project)

Background Atena project involved 5,062 women aged 30 to 69 years living in the area of Naples. The purpose of this study is to investigate the causes of those chronic diseases that have a major impact on the female population. As a part of the design (scheduled in 2002-2004). After 10 years, in 228 women, some biochemical measurements were performed. Methods This systematic review and meta-analysis biomarkers were evaluated in studies nested into the Atena cohort. Studies were searched using MEDLINE/PubMed. The search was performed by entering individually or in combination: Atena, Mediterranean woman, biomarkers. The preferred reporting of systematic reviews and meta-analysis (PRISMA) guidelines were used for the review. Studies selected for this review are conducted in the Atena project Cohort and reported the study of biomarkers. Disagreements on data extractions between the two investigators were solved by consensus. The extracted data were entered and analyzed using REVMAN software. The original articles were described using forest plot and table. Heterogeneity was computed by Cochran’s Q test. Results The search strategy retrieved 13 potential articles, 11 were screened as full text articles and 6 were included in the pooled estimates. Among the articles included, biomarkers chosen as predictors were Lipids, Hcrp, as prognostic where predictive of IMT; and cycle length and LPa as predictive of an augmented LDL cholesterol mean. According to the comparability of data presented, for the first comparison we selected 3 of the 5 studies that assed IMT, for the second we selected 2 of the three studies that analyzed for LDL mean. Results were shown into forrest plots. The pooled estimates verified the potential of biomarkers as predictor of IMT, the significance seemed lower for prediction of LDL cholesterol. Conclusions Both results, consistent with the multifactor profile of the CV risk, identify the impact of secondary prevention according to biochemical profiles. Key messages Biomarkers studied in nested cohort stufies have predictive potential. pooled estimates may identify the impact of secondary prevention according to biochemical profiles.

Islamic hedging for pilgrimage funds: case of Indonesia

Purpose The demand for Saudi Arabian real (SAR) is very high in the pilgrimage (hajj) season while the authority, unfortunately, does not hedge the hajj funds. As such, the hajj funds are potentially exposed to exchange rate risk, which can impact the value of hajj funds and generate extra cost to the pilgrims. The purpose of this paper is to conduct simulations of Islamic hedging for pilgrimage funds to: mitigate and minimize exchange rate risk, identify and recommend the ideal time, amount and tenors of Islamic hedging for hajj funds, estimate cost saving by pursuing Islamic hedging and propose technical and general recommendations for the authority. Design/methodology/approach Forward transaction mechanism is adopted to compute Islamic forward between SAR and Rupiah (Indonesian currency) or IDR. Findings – based on simulations, the paper finds that: the longer the Islamic hedging tenors, the better is the result of Islamic hedging, the decreasing of IDR/USD is the right time to hedge the hajj funds and, on the other hand, the IDR/SAR appreciation is not the right time to hedge the hajj funds. Findings Based on simulations, the paper finds that: the longer the Islamic hedging tenors, the better is the result of Islamic hedging, the decreasing of IDR/USD is the right time to hedge the hajj funds and, on the other hand, the IDR/SAR appreciation is not the right time to hedge the hajj funds. Research limitations/implications The research suggests the authority to (and not to) hedge the hajj fund, depending on economic conditions and market indicators. Even though the assessment is for the Indonesian case, other countries maintaining hajj funds might also learn from this paper. Originality/value To the best of author’s knowledge, this is the first paper in Indonesia that attempts to simulate the optimal hedging of hajj funds.

Filtering Out Use of DOACs in Hemodialysis

Published data exploring the best approach to initiating and maintaining anticoagulation in the setting of renal support therapy are scarce, as these patients were excluded in clinical trials. When developing an anticoagulation regimen in this setting, it is important to assess thrombosis risk, identify the unique drivers for thrombosis and bleeding, and recognize the limitations of supporting evidence behind approved prescribing indications for renal impairment. Available literature and considerations for using direct acting oral anticoagulants in the setting of renal support are reviewed.

THE ROLE OF TRANSNATIONAL BANKS IN THE TRANSMISSION OF GLOBAL SYSTEMIC RISK

Introduction. One of the manifestations of financial globalization is the formation and development of cross-border links of transnational banks. This expands opportunities for investment and contributes to the economic development of many countries. At the same time, the increasing complexity of financial ties strengthens the cross-border interdependence of transnational banks, leading to the transfer of financial shocks that arise in some countries to others. The purpose. The article aims to explore the role of multinational banks in the transmission of global systemic risk, identify existing problems supervision of multinational banks as globally systemically important financial institutions and identify solutions. Results. The article deals with the processes of transmission by transnational banks of global systemic risk in the framework of the “theory of infection of financial markets”. The influence of the “general creditor effect” on the spread of crisis phenomena between the economies of different countries is analyzed. The direction of influence of cross-border links of transnational banks on financial stability of the banking system of the country is clarified. Approaches to the identification of globally systemically important banks have been highlighted in accordance with international practice, and tasks have been identified to strengthen regulation and supervision of the activities of transnational banks. Conclusion. Today, regulators have limited ability to prevent the transmission of global systemic risk multinational banks. Many institutional mechanisms exist at national level and aimed at maintaining the financial stability of banking systems and crisis management of banks, there are no globally. However, only coordinated decisions on measures of overcoming the crisis can ensure effective implementation of anti-crisis programs globally

Work histories and the access to contributory pensions: the case of Uruguay

Incomplete and highly fragmented work histories threaten to leave many contributors of the pension schemes in Latin America without the minimum pension guarantee or even without access to the ordinary pension. We propose a methodology to assess this risk, identify vulnerable groups and study potential determinants of the history of contributions using information from the work history records of the social security institutions. We apply this methodology to the largest social security institution of Uruguay, the Banco de Previsión Social (BPS), and show that the majority of contributors to this institution might not comply with the minimum number of years of contribution that is currently required to access an ordinary pension when they reach the retirement age.