Primary Pulmonary Acinic Cell Carcinoma: A Clinicopathological Study of 6 Cases and Literature Review

2019 ◽  
Vol 27 (6) ◽  
pp. 584-592 ◽  
Author(s):  
Ling Nie ◽  
Chunlei Zhou ◽  
Hongyan Wu ◽  
Qiang Zhou ◽  
Fanqing Meng
Keyword(s):  
Cell Carcinoma ◽  
Comprehensive Evaluation ◽  
Clinicopathological Features ◽  
Acinic Cell Carcinoma ◽  
Mitotic Figure ◽  
Neoplastic Cells ◽  
Acinic Cell ◽  
S 100 ◽  
The Difference ◽  
The Right

Primary pulmonary acinic cell carcinoma (ACC) is rare. The clinicopathological features are not identical to that of classic ACC that leads to misdiagnosis. In this article, we summarized the clinicopathological features of 25 such cases, including 6 cases in this series and additional 19 cases in the literature. Pulmonary ACCs showed an overwhelming solid growth pattern. The neoplastic cells had eosinophilic granular and clear cytoplasm in most cases and displayed basophilic cytoplasm in only 4 cases. Intratumoral fibrous septa, mitotic figure, necrosis, and psammoma bodies were observed in some cases. Prominent nuclear atypia and perineural invasion might suggest high-grade transformation, metastasis, and recurrence. The tumor cells were strongly positive for CK8/18 and negative for TTF-1, p63, S-100, mammaglobin, MUC5b, MUC5ac, and DOG1. CK7 was exclusively positive for neoplastic cells with ductal differentiation. Of the 25 included cases, 10 cases were initially misdiagnosed. The tumor was prone to involve the right bronchus. The patient outcome was favorable. The accurate diagnosis of primary pulmonary ACC relies on comprehensive evaluation of histological and immunohistochemical features and realization of the difference from classic ACC.

Multiple acinic cell carcinoma

1985 ◽  
Vol 99 (11) ◽  
pp. 1183-1193 ◽  
Author(s):  
H. Gustafsson ◽  
B. Carlsöö
Keyword(s):  
Parotid Gland ◽  
Cell Carcinoma ◽  
Submaxillary Gland ◽  
Acinic Cell Carcinoma ◽  
Salivary Gland Tumours ◽  
Acinic Cell ◽  
Ultrastructural Characteristics ◽  
The Right ◽  
Parotid Gland Tumours ◽  
Left Parotid Gland

AbstractA case is presented of multiple acinic cell carcinoma, occurring synchronously in the left parotid gland and in the right submaxillary gland of a 75-year-old male patient. Fourteen cases of primary multiple acinic cell carcinoma have previously been reported, all bilateral parotid gland tumours. To our knowledge this is the first report of extraparotid localization of an acinic cell carcinoma in a patient presenting multiple salivary gland tumours. The histologic and ultrastructural characteristics of the tumours are described and a review of the literature is given.

scholarly journals Utility of Immunohistochemistry and ETV6 (12p13) Gene Rearrangement in Identifying Secretory Carcinoma of Salivary Gland among Previously Diagnosed Cases of Acinic Cell Carcinoma

2017 ◽  
Vol 2017 ◽  
pp. 1-7 ◽  
Author(s):  
Rana Naous ◽  
Shengle Zhang ◽  
Alfredo Valente ◽  
Melissa Stemmer ◽  
Kamal K. Khurana
Keyword(s):  
Salivary Gland ◽  
Cell Carcinoma ◽  
Gene Rearrangement ◽  
Genetic Alterations ◽  
Interstitial Deletion ◽  
Acinic Cell Carcinoma ◽  
Secretory Carcinoma ◽  
Acinic Cell ◽  
S 100 ◽  
Initial Description

Objective. Secretory carcinoma is a recently described entity with characteristic immunoprofile and ETV6 (12p13) rearrangement. Before its initial description, it was generally diagnosed as acinic cell carcinoma (ACCi). We evaluated immunoprofile and ETV6 rearrangement in cytological and surgical cases of previously diagnosed ACCi, in an attempt to identify any misclassified SC. Methods. Fifteen cytology and surgical cases of ACCi diagnosed over a 13-year period were retrieved and subjected to immunohistochemistry for S-100, mammaglobin, GATA-3 and DOG-1 as well as FISH for ETV6 (12p13). Results. Of the 8 cytology cases, only 1 was positive for S100, GATA-3, and mammaglobin, and negative for DOG-1. It also demonstrated ETV6 rearrangement and was reclassified as SC. The same immunoprofile was present in 2 of the 13 surgical cases. ETV6 rearrangement characterized by 3′ interstitial deletion was detected in one of these cases and was reclassified as SC. Immunohistochemistry and ETV6 rearrangement were useful in identifying 2 (13.3%) cases misclassified as ACCi. Conclusions. Characteristic immunoprofile and ETV6 gene rearrangement may prove useful in identifying cases of SC. The presence of ETV6 3′ interstitial deletion in one of our cases suggests that there may be additional ETV6 related genetic alterations contributing to the pathogenesis of SC.

scholarly journals Primary Acinic Cell Carcinoma of the Breast: A Clinicopathological and Immunohistochemical Study

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Kiyoshi Shingu ◽  
Tokiko Ito ◽  
Gengo Kaneko ◽  
Nobuo Itoh
Keyword(s):  
Cell Carcinoma ◽  
Tumor Cells ◽  
Growth Factor Receptor ◽  
Malignant Neoplasm ◽  
Lymph Node Biopsy ◽  
Acinic Cell Carcinoma ◽  
Low Grade ◽  
Carcinoma Of The Breast ◽  
Acinic Cell ◽  
S 100

Acinic cell carcinoma of the breast is an extremely rare, malignant neoplasm characterized by widespread acinar cell-like differentiation and clinically low-grade malignancy. Herein, we report a case of acinic cell carcinoma of the breast in a 41-year-old woman. The tumor was poorly demarcated but had a firm consistency. It was removed with lumpectomy, and sentinel lymph node biopsy was performed to check for metastasis. Microscopically, the tumor showed an infiltrative growth pattern with a combination of solid, trabecular, and microglandular areas. Many of the tumor cells had abundant clear vacuolated cytoplasm containing zymogen-typed granules which resemble acinar cells of the salivary glands. The immunohistochemical profile of the tumor was also similar to that of salivary gland acinic cell carcinoma: the tumor cells were positive for amylase, lysozyme,α-1-antichymotrypsin, S-100 protein, and epithelial membrane antigen and negative for estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2. She received postoperative chemoradiation therapy and has been well for 3 years since surgery. As studies on large series are lacking, further studies are needed to elucidate the biological characteristics of acinic cell carcinoma of the breast.

Acinic Cell Carcinoma of the Breast: Report of a Case With Immunohistochemical and Next-Generation Sequencing Studies

2021 ◽  
pp. 106689692110085
Author(s):  
Kaitlin D. Weaver ◽  
James Isom ◽  
Ashwini Esnakula ◽  
Karen Daily ◽  
Jaya R. Asirvatham
Keyword(s):  
Next Generation Sequencing ◽  
Cell Carcinoma ◽  
Triple Negative ◽  
Ductal Carcinoma ◽  
Left Breast ◽  
Acinic Cell Carcinoma ◽  
Next Generation ◽  
Carcinoma Of The Breast ◽  
Acinic Cell ◽  
Generation Sequencing

Acinic cell carcinoma of the breast is a rare subtype of triple-negative breast cancer that recapitulates the appearance of tumors seen in salivary glands. We present the case of a 42-year-old woman with an irregular, nontender mass above the left nipple during routine obstetric appointment at 24 weeks gestation. She was subsequently diagnosed with triple-negative invasive ductal carcinoma of the left breast, Nottingham grade 3, via core needle biopsy. She was treated with neoadjuvant therapy (doxorubucin and cyclophosphamide) antenatally and paclitaxel in the postpartum period followed by left mastectomy with sentinel node biopsy. The carcinoma in the mastectomy specimen showed a spectrum of morphologic patterns with immunohistochemistry revealing strong positivity for alpha-1-antichymotrypsin, epithelial membrane antigen (EMA), lysozyme, and S100. The histomorphology paired with the immunoprofile led us to the diagnosis of acinic cell carcinoma. We retrospectively performed immunostains in the core biopsy specimen, which demonstrated GATA-3 and DOG-1 positivity. Next-generation sequencing of the postneoadjuvant specimen using a 70-gene panel revealed 2 single-nucleotide variant (SNV) mutations: tumor protein 53 (TP53) (c.747G>T) SNV mutation and rearranged during transfection (RET) (c.2899G>A) SNV mutation.

scholarly journals Acinic cell carcinoma of the salivary glands: A literature review

2009 ◽  
Vol 2 (1) ◽  
pp. 259-264 ◽  
Author(s):  
Nabil Al-Zaher ◽  
Amani Obeid ◽  
Suhail Al-Salam ◽  
Bassam Sulaiman Al-Kayyali
Keyword(s):  
Literature Review ◽  
Cell Carcinoma ◽  
Salivary Glands ◽  
Acinic Cell Carcinoma ◽  
Acinic Cell

scholarly journals High-Grade Transformation of Acinic Cell Carcinoma: Potentially Underrecognized and Inadequately Treated

2016 ◽  
Vol 94 (4) ◽  
pp. 946
Author(s):  
A.V. Chintakuntlawar ◽  
W. Shon ◽  
M. Erickson-Johnson ◽  
E. Bilodeau ◽  
S. Jenkins ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Acinic Cell Carcinoma ◽  
High Grade ◽  
Acinic Cell ◽  
High Grade Transformation

Clinicopathological analysis of oral and maxillofacial acinic cell carcinoma: A systematic review

2021 ◽  
Author(s):  
Laura Borges Kirschnick ◽  
Felipe Martins Silveira ◽  
Lauren Frenzel Schuch ◽  
Felipe Paiva Fonseca ◽  
Marco Antonio Trevizani Martins ◽  
...  
Keyword(s):  
Systematic Review ◽  
Cell Carcinoma ◽  
Acinic Cell Carcinoma ◽  
Acinic Cell ◽  
Clinicopathological Analysis

P36.01 Primary Acinic Cell Carcinoma of Bronchial Ground Origin: A Case Report

2021 ◽  
Vol 16 (10) ◽  
pp. S1062-S1063
Author(s):  
K. Hirano ◽  
H. Harada ◽  
S. Shibata ◽  
E. Chou ◽  
Y. Naka ◽  
...  
Keyword(s):  
Case Report ◽  
Cell Carcinoma ◽  
Acinic Cell Carcinoma ◽  
Acinic Cell

scholarly journals A Case Report and Genetic Characterization of a Massive Acinic Cell Carcinoma of the Parotid with Delayed Distant Metastases

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Anthony C. Nichols ◽  
Michelle Chan-Seng-Yue ◽  
John Yoo ◽  
Sumit K. Agrawal ◽  
Maud H. W. Starmans ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Cell Carcinoma ◽  
Large Scale ◽  
Cellular Proliferation ◽  
Genetic Characterization ◽  
Distant Metastases ◽  
Acinic Cell Carcinoma ◽  
Nonsynonymous Mutation ◽  
Acinic Cell

We describe the presentation, management, and clinical outcome of a massive acinic cell carcinoma of the parotid gland. The primary tumor and blood underwent exome sequencing which revealed deletions in CDKN2A as well as PPP1R13B, which induces p53. A damaging nonsynonymous mutation was noted in EP300, a histone acetylase which plays a role in cellular proliferation. This study provides the first insights into the genetic underpinnings of this cancer. Future large-scale efforts will be necessary to define the mutational landscape of salivary gland malignancies to identify therapeutic targets and biomarkers of treatment failure.

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