scholarly journals An Investigation of ABO Blood Type and the Platelet Delta Granule Storage Pool

2021 ◽  
Vol 27 ◽  
pp. 107602962110688
Author(s):  
Ryan J. Reagans ◽  
Paula M. Kramer ◽  
Jacob A. Cichocki ◽  
William T. Gunning
Keyword(s):  
Dense Granule ◽  
Blood Type ◽  
Storage Pool ◽  
Platelet Storage ◽  
Number Of Patients ◽  
Study Population ◽  
Abo Blood Type ◽  
Von Willebrand ◽  
Willebrand Factor ◽  
The U.S

Individuals with bleeding tendencies are more likely to have blood type O than blood types A, B, or AB. Platelet storage pool deficiencies are a lesser-known group of bleeding disorders which often go undiagnosed and may account for a significant number of patients with unexplained bleeding defects. We hypothesized that patients with platelet δ-storage pool deficiency might also have a predominance of type O blood. A retrospective review of medical records of 2,020 patients with unexplained bleeding and evaluated for δ-storage pool deficiency was performed. Correlations between dense granule numbers, blood type, and von Willebrand factor were analyzed for statistical differences. 51.5% of blood samples were blood type O compared to an incidence of 44.0% in the U.S. population. There was a significant association of vWF and blood type O but not with the delta storage pool. There is a preponderance of blood type O in the study population compared to the U.S. population. There is no statistically significant link between blood type O and lower dense granule numbers in this study.

scholarly journals Aging and ABO blood type influence von Willebrand factor and factor VIII levels through interrelated mechanisms

2016 ◽  
Vol 14 (5) ◽  
pp. 953-963 ◽  
Author(s):  
S. Albánez ◽  
K. Ogiwara ◽  
A. Michels ◽  
W. Hopman ◽  
J. Grabell ◽  
...  
Keyword(s):  
Factor Viii ◽  
Von Willebrand Factor ◽  
Blood Type ◽  
Abo Blood Type ◽  
Von Willebrand ◽  
Willebrand Factor

scholarly journals Carrier detection in hemophilia A: a cooperative international study. I. The carrier phenotype

Blood ◽  
1986 ◽  
Vol 67 (6) ◽  
pp. 1554-1559 ◽  
Author(s):  
JB Graham ◽  
CR Rizza ◽  
J Chediak ◽  
PM Mannucci ◽  
E Briet ◽  
...  
Keyword(s):  
Hemophilia A ◽  
International Study ◽  
Blood Type ◽  
Carrier Detection ◽  
Heterozygous Carriers ◽  
Abo Blood Type ◽  
Normal Women ◽  
Von Willebrand ◽  
Willebrand Factor ◽  
Striking Effect

Abstract Eight laboratories in six countries cooperated to clarify several issues concerning the phenotypes of heterozygous carriers of hemophilia “A.” Plasma levels of factor VIII (F.VIII:C, formerly VIII:C) and von Willebrand factor (VWF:Ag, formerly VIIIR:Ag) of carriers and normal women were determined by various “in-house” methods; a single lyophilized plasma standard was used for all assays. Analysis of the collated data from 336 carriers (296 obligatory carriers and 40 sporadic carriers) and 137 normal women showed that there was no difference in the F.VIII:C levels of “paternal” carriers (women who had obtained the abnormal gene from their fathers) and “maternal” carriers. Neither was there a difference in the VWF:Ag levels of normal women and either type of carrier. Age was found to have a significant effect on both F.VIII:C and VWF:Ag, values being higher at very young and very old ages, the minima occurring in the 25- to 30-year range. ABO blood type had a striking effect. Women of types A, B, and AB (designated non- O in the study), both normals and carriers, had significantly higher levels of both factors than did women of type O. Analysis by laboratories showed that differences in mean levels of both factors between laboratories were highly significant. It was concluded that age, ABO blood type, and laboratory variation should be taken into account in carrier detection.

scholarly journals Measurement of von Willebrand factor activity: relative effects of ABO blood type and race

2003 ◽  
Vol 1 (10) ◽  
pp. 2191-2197 ◽  
Author(s):  
C. H. Miller ◽  
E. Haff ◽  
S. J. Platt ◽  
P. Rawlins ◽  
C. D. Drews ◽  
...  
Keyword(s):  
Von Willebrand Factor ◽  
Blood Type ◽  
Factor Activity ◽  
Abo Blood Type ◽  
Von Willebrand ◽  
Willebrand Factor

scholarly journals A decreased and less sustained desmopressin response in hemophilia A carriers contributes to bleeding

2018 ◽  
Vol 2 (20) ◽  
pp. 2629-2636 ◽  
Author(s):  
Victoria Candy ◽  
Hilary Whitworth ◽  
Julie Grabell ◽  
Lisa Thibeault ◽  
Lori Harpell ◽  
...  
Keyword(s):  
Hemophilia A ◽  
Assessment Tool ◽  
Blood Type ◽  
Thrombin Generation Assay ◽  
Impaired Ability ◽  
Abnormal Bleeding ◽  
Abo Blood Type ◽  
Bleeding Score ◽  
Von Willebrand ◽  
Willebrand Factor

Abstract The cause of hemophilia A carrier bleeding is not well established. Desmopressin (DDAVP), used clinically to treat or prevent bleeding, can also be used as a medical stress surrogate. This study’s objective was to compare the response to DDAVP in hemophilia A carriers with that in normal control patients. Bleeding was assessed by the International Society on Thrombosis and Hemostasis Bleeding Assessment Tool (ISTH-BAT). DDAVP (0.3 μg/kg) was administered either IV or subcutaneously (SC), and blood was drawn at baseline and 1, 2, and 4 hours postadministration. Blood was assessed for factor VIII (FVIII) level, von Willebrand factor (VWF) antigen (VWF:Ag), VWF activity (VWF:RCo or VWF:GPIbM), thromboelastography (TEG), and thrombin generation assay (TGA) at all points, and for VWF propeptide (VWFpp):Ag ratio and ABO blood type at baseline. Carriers were older than control patients (median age, 34 and 21 years, respectively; P = .003) and had higher ISTH-BAT bleeding scores (median bleeding score, 8 and 0, respectively; P = .001). Carriers had a significantly reduced FVIII response to DDAVP compared with control patients (P ≤ .0001). When only carriers with normal baseline FVIII levels (n = 10) were included, carriers maintained a reduced FVIII response (P ≤ .0001). Furthermore, participants with abnormal bleeding scores had a significantly lower FVIII response to DDAVP compared with those with normal bleeding scores (P = .036). Hemophilia A carriers have a lower and less sustained FVIII response to DDAVP, suggesting an impaired ability to respond to hemostatic stress, which contributes to bleeding.

Abstract 125: Association Between Abo Blood Group, Von Willebrand Factor and Factor VIII in Patients Undergoing Vascular Surgery

2017 ◽  
Vol 37 (suppl_1) ◽  
Author(s):  
Francisco Ujueta ◽  
Michael A Nardi ◽  
Yu Guo ◽  
Adriana Perez ◽  
Maya Rubin ◽  
...  
Keyword(s):  
Vascular Surgery ◽  
Factor Viii ◽  
Von Willebrand Factor ◽  
Statistical Significance ◽  
Blood Groups ◽  
Blood Type ◽  
Abo Blood Groups ◽  
Abo Blood Type ◽  
Von Willebrand ◽  
Willebrand Factor

Background: ABO blood groups have been associated with functional effects on factor VIII (FVIII), von Willebrand factor (vWF) and incident atherothrombosis. This study sought to examine the association between ABO blood type, FVIII and vWF in patients undergoing vascular surgery. Method: This is a retrospective analysis of data from a cohort of 181 patients undergoing elective vascular surgery. ABO blood type, FVIII and vWF was measured before surgery. The primary end point was the occurrence of MACE (defined as myocardial necrosis, myocardial infarction, stroke or death) within 30-days after surgery. Multivariable logistic regression modeling was used to estimate odds of MACE. Results: The mean age was 71.6 ± 9.8 and 29% were female. Non-O blood type was present in 105 patients (70 A, 27 B, 8 AB) and type O in 76 patients. Non-O had higher FVIII (128.2 ± 44.7 vs 112.4 ± 42.4, P<0.001) and vWF (176.0 ± 54.0 vs 133.2 ± 41.0, P<0.001) than type O. Thirty day MACE occurred in 38 (21.0%) patients; 25% in non-O and 15.8% in type O (P=0.13). After adjustment for age, sex, race, prior coronary artery disease and heart failure, patients with non-O blood type (vs. O) had a higher incidence of 30-day MACE (odds ratio 2.1, 95% CI 0.9 to 5.1, P=0.08) although statistical significance was not reached. There was no significant association between FVIII and vWF and 30-day MACE. Conclusions: Non-O blood type was associated with higher levels of FVIII and vWF and a trend towards increased 30-day MACE in patients undergoing vascular surgery. Larger studies across of ABO blood groups and perioperative events in different types of surgeries are warranted.

scholarly journals Carrier detection in hemophilia A: a cooperative international study. I. The carrier phenotype

Blood ◽  
1986 ◽  
Vol 67 (6) ◽  
pp. 1554-1559
Author(s):  
JB Graham ◽  
CR Rizza ◽  
J Chediak ◽  
PM Mannucci ◽  
E Briet ◽  
...  
Keyword(s):  
Hemophilia A ◽  
International Study ◽  
Blood Type ◽  
Carrier Detection ◽  
Heterozygous Carriers ◽  
Abo Blood Type ◽  
Normal Women ◽  
Von Willebrand ◽  
Willebrand Factor ◽  
Striking Effect

Eight laboratories in six countries cooperated to clarify several issues concerning the phenotypes of heterozygous carriers of hemophilia “A.” Plasma levels of factor VIII (F.VIII:C, formerly VIII:C) and von Willebrand factor (VWF:Ag, formerly VIIIR:Ag) of carriers and normal women were determined by various “in-house” methods; a single lyophilized plasma standard was used for all assays. Analysis of the collated data from 336 carriers (296 obligatory carriers and 40 sporadic carriers) and 137 normal women showed that there was no difference in the F.VIII:C levels of “paternal” carriers (women who had obtained the abnormal gene from their fathers) and “maternal” carriers. Neither was there a difference in the VWF:Ag levels of normal women and either type of carrier. Age was found to have a significant effect on both F.VIII:C and VWF:Ag, values being higher at very young and very old ages, the minima occurring in the 25- to 30-year range. ABO blood type had a striking effect. Women of types A, B, and AB (designated non- O in the study), both normals and carriers, had significantly higher levels of both factors than did women of type O. Analysis by laboratories showed that differences in mean levels of both factors between laboratories were highly significant. It was concluded that age, ABO blood type, and laboratory variation should be taken into account in carrier detection.

scholarly journals Platelet storage pool deficiency in pigs

Blood ◽  
1986 ◽  
Vol 67 (4) ◽  
pp. 1043-1047 ◽  
Author(s):  
TM Daniels ◽  
DN Fass ◽  
JG White ◽  
EJ Bowie
Keyword(s):  
Storage Pool ◽  
Clinically Normal ◽  
Platelet Storage ◽  
Transmission Electron ◽  
Heterozygous Carriers ◽  
Von Willebrand ◽  
Willebrand Factor ◽  
Factor Antigen ◽  
Ristocetin Cofactor

Abstract We report a new bleeding disease--storage pool deficiency (SPD) of platelets--in pigs from the Mayo swine colony of homozygous von Willebrand's disease (vWD) and of heterozygous carriers of vWD. Levels of factor VIII, von Willebrand factor antigen (vWF:Ag), and ristocetin cofactor (RCof) were similar in the vWD carriers and SPD pigs. The latter pigs, however, had bleeding times of 15 minutes or more and were severe bleeders, in contrast to clinically normal vWD carriers. Platelet aggregation in response to collagen was reduced in most SPD pigs. Total platelet content of ADP, ATP, and serotonin was less than that of normal pigs. While the initial uptake of 14C-labeled serotonin into platelets was similar in SPD and normal pigs, retention of serotonin was reduced in platelets of SPD pigs. Transmission electron microscopy showed a large decrease of dense bodies in the platelets of SPD pigs. These findings support a diagnosis of SPD. Genetic analyses suggest an autosomal recessive mode of inheritance. A breeding program is under way to produce pigs affected only at the SPD gene, thus allowing further characterization of SPD and SPD-carrier pigs.

scholarly journals Platelet storage pool deficiency in pigs

Blood ◽  
1986 ◽  
Vol 67 (4) ◽  
pp. 1043-1047
Author(s):  
TM Daniels ◽  
DN Fass ◽  
JG White ◽  
EJ Bowie
Keyword(s):  
Storage Pool ◽  
Clinically Normal ◽  
Platelet Storage ◽  
Transmission Electron ◽  
Heterozygous Carriers ◽  
Von Willebrand ◽  
Willebrand Factor ◽  
Factor Antigen ◽  
Ristocetin Cofactor

We report a new bleeding disease--storage pool deficiency (SPD) of platelets--in pigs from the Mayo swine colony of homozygous von Willebrand's disease (vWD) and of heterozygous carriers of vWD. Levels of factor VIII, von Willebrand factor antigen (vWF:Ag), and ristocetin cofactor (RCof) were similar in the vWD carriers and SPD pigs. The latter pigs, however, had bleeding times of 15 minutes or more and were severe bleeders, in contrast to clinically normal vWD carriers. Platelet aggregation in response to collagen was reduced in most SPD pigs. Total platelet content of ADP, ATP, and serotonin was less than that of normal pigs. While the initial uptake of 14C-labeled serotonin into platelets was similar in SPD and normal pigs, retention of serotonin was reduced in platelets of SPD pigs. Transmission electron microscopy showed a large decrease of dense bodies in the platelets of SPD pigs. These findings support a diagnosis of SPD. Genetic analyses suggest an autosomal recessive mode of inheritance. A breeding program is under way to produce pigs affected only at the SPD gene, thus allowing further characterization of SPD and SPD-carrier pigs.

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