The Brief Repeatable Battery of Neuropsychological Tests: normative values allow application in multiple sclerosis clinical practice

2001 ◽  
Vol 7 (4) ◽  
pp. 263-267 ◽  
Author(s):  
J B Boringa ◽  
R HC Lazeron ◽  
I EW Reuling ◽  
H J Adèr ◽  
L EMA Pfennings ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Test Scores ◽  
Neuropsychological Tests ◽  
Word List ◽  
Normative Values ◽  
Gender And Education ◽  
Selective Reminding ◽  
Repeatable Battery ◽  
Serial Addition ◽  
Selective Reminding Test

The Brief Repeatable Battery of Neuropsychological Tests (BRB-N) is a sensitive measure of cognitive impairment in multiple sclerosis (MS) patients. It consists of the Selective Reminding Test, the 10/36 Spatial Recall Test, the Symbol Digit Modalities Test, the Paced Auditory Serial Addition Test and the Word List Generation Test. We administered one of two parallel versions of the test battery to 140 healthy subjects to produce normative values for both versions. As expected, test scores were influenced by certain variables like age, gender and education. Although constructed as two equivalent versions, for some tests the two versions showed significant differences in test scores, which could not be explained by differences in these variables.

The Rao’s Brief Repeatable Battery and Stroop test: normative values with age, education and gender corrections in an Italian population

2006 ◽  
Vol 12 (6) ◽  
pp. 787-793 ◽  
Author(s):  
M P Amato ◽  
E Portaccio ◽  
B Goretti ◽  
V Zipoli ◽  
L Ricchiuti ◽  
...  
Keyword(s):  
Normative Values ◽  
Italian Population ◽  
Long Term Storage ◽  
Selective Reminding ◽  
Repeatable Battery ◽  
Serial Addition ◽  
And Gender ◽  
Selective Reminding Test ◽  
Relevant Factors

The Brief Repeatable Battery of Neuropsychological Tests (BRB) is by far the most widely used instrument to estimate cognitive dysfunction in multiple sclerosis (MS) patients. However, the paucity of normative data currently limits its applicability. We administered the BRB to 200 healthy subjects to obtain normative values. Moreover, we assessed the influence of demographic factors on the test scores and calculated corrections for these relevant factors. To test executive functions not explored by the BRB, we also included the Stroop word-color task (ST). Higher educational level was associated with better performance on all the tests, except for the world list generation (WLG) and the ST, considering version A, and on Symbol Digit Modalities Test (SDMT), Paced Auditory Serial Addition Test (PASAT) and Selective Reminding Test-Delayed (SRT-D), considering version B. Females performed better than males on the WLG considering version A, and on the SRT-Long Term Storage (SRT-LTS) and SRT-Consistent Long Term Retrieval (SRT-CLTR) considering version B. Increasing age was associated with worse performance on the ST in version A, and on the SRT-LTS, SRT-CLTR and WLG in version B. Our data can improve the applicability of the BRB for both clinical and research purposes.

The brief repeatable battery of neuropsychological tests for multiple sclerosis: a preliminary serial study

1995 ◽  
Vol 1 (3) ◽  
pp. 165-169 ◽  
Author(s):  
CT Bever ◽  
L Grattan ◽  
HS Panitch ◽  
KP Johnson
Keyword(s):  
Neuropsychological Tests ◽  
Word List ◽  
Practice Effect ◽  
Rank Test ◽  
Selective Reminding ◽  
Signed Rank ◽  
Signed Rank Test ◽  
Repeatable Battery ◽  
Serial Addition ◽  
Cognitive Fluctuations

The Brief Repeatable Battery of Neuropsychological Tests (BRB-N) for MS consisting of the selective reminding, 10136 spatial recall, symbol digit modalities, paced auditory serial addition (PASAT) and word list generation tests is a sensitive measure of early cognitive impairment in MS patients. We administered it to 19 chronic stable MS patients every 60 days for 120 days to examine variability. The mean coefficient of variation for the tests ranged from 18% to 22%. A significant practice effect was seen in the PASAT results (P<0.05) using the Wilcoxon signed rank test These results suggest that cognitive fluctuations analogous to motor fluctuations may occur in MS patients and that the BRB-N may be useful in clinical trials of agents expected to alter cognitive function in MS patients if test-retest variability and practice effects are taken into account Further study is warranted.

scholarly journals Correlation between olfactory dysfunction and various clinical parameters in patients with multiple sclerosis

2009 ◽  
Vol 66 (3) ◽  
pp. 203-206 ◽  
Author(s):  
Jelena Kostic ◽  
Elka Stefanova ◽  
Tatjana Pekmezovic ◽  
Jelena Drulovic
Keyword(s):  
Multiple Sclerosis ◽  
Cognitive Functions ◽  
Clinical Manifestations ◽  
Cognitive Disorders ◽  
Word List ◽  
Chronic Inflammatory Disease ◽  
Olfactory Dysfunction ◽  
Normative Values ◽  
Clinical Parameters ◽  
Serial Addition

Background/Aim. Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) characterized by myelin destruction and axon loss. Among various clinical manifestations of MS cognitive disorders are frequent. Olfactory disorders are also noticed but they are rarely considered in clinical practice. The aim of the present study was to examine frequency of olfactory dysfunction in patients with MS and its relationship to clinical parameters. Methods. Our study comprised 61 consecutive patients with definite MS who were hospitalized at the Department for Multiple Sclerosis and Other Immune- Mediated Disorders of CNS, Institute of Neurology, Clinical Center of Serbia, Belgrade, and 45 gender-, age- and education-matched healthy voluntaries. The Pocket Smell Test (PST) was used for examination of olfactory function. Cognitive functions were analyzed using the tests from the Brief Battery of Neuropsychological Tests: Paced Auditory Serial Addition Test 3-minute Version (PASAT 3'), Word List Generation (WLG) and Symbol Digit Modalities Test (SDMT). Results. Olfactory dysfunction was found in 26 (43%) MS patients and 5 (11%) controls (p = 0.001). Statistically significant positive correlation was found only between PST score and WLG scores (r = 0.297, p = 0.030). In comparison with the previously published normative values, our subjects with MS had decrease in the mean indices of the PASAT 3' in 28%, SDMT in 51% and WLG in 90% of the subjects. Conclusion. Olfactory dysfunction is frequent in our population of patients with MS. This disturbance correlates with the impairment of cognitive functions in these patients.

The Brief Repeatable Battery of Neuropsychological Tests: normative values allow application in multiple sclerosis clinical practice

2001 ◽  
Vol 7 (4) ◽  
pp. 263-267 ◽  
Author(s):  
J.B. Boringa ◽  
R.H.C. Lazeron ◽  
I.E.W. Reuling ◽  
H.J. Adèr ◽  
L.E.M.A. Pfennings ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Clinical Practice ◽  
Neuropsychological Tests ◽  
Normative Values ◽  
Repeatable Battery

scholarly journals BRBN-T validation: adaptation of the Selective Reminding Test and Word List Generation

2015 ◽  
Vol 73 (10) ◽  
pp. 867-872 ◽  
Author(s):  
Mariana Rigueiro Neves ◽  
Ana Margarida Passos ◽  
Aristides Ferreira ◽  
Cláudia Sousa ◽  
Andreia Sá ◽  
...  
Keyword(s):  
Neuropsychological Tests ◽  
Cognitive Rehabilitation ◽  
Item Analysis ◽  
Classical Test Theory ◽  
Word List ◽  
Test Theory ◽  
Therapeutic Effects ◽  
Selective Reminding ◽  
Selective Reminding Test ◽  
Healthy Participants

Objective This study aims to present the Selective Reminding Test(SRT) and Word List Generation (WLG) adaptation to the Portuguese population, within the validation of the Brief Repeatable Battery of Neuropsychological Tests (BRBN-T)for multiple sclerosis (MS) patients.Method 66 healthy participants (54.5% female) recruited from the community volunteered to participate in this study.Results A combination of procedures from Classical Test Theory (CTT) and Item Response Theory (ITR) were applied to item analysis and selection. For each SRT list, 12 words were selected and 3 letters were chosen for WLG to constitute the final versions of these tests for the Portuguese population.Conclusion The combination of CTT and ITR maximized the decision making process in the adaptation of the SRT and WLG to a different culture and language (Portuguese). The relevance of this study lies on the production of reliable standardized neuropsychological tests, so that they can be used to facilitate a more rigorous monitoring of the evolution of MS, as well as any therapeutic effects and cognitive rehabilitation.

scholarly journals Assessment of cognition using the Rao's Brief Repeatable Battery of Neuropsychological Tests on a group of Brazilian patients with multiple sclerosis

2011 ◽  
Vol 69 (6) ◽  
pp. 887-891 ◽  
Author(s):  
Joseph Bruno Bidin Brooks ◽  
Mariana Cossi Monseff Borela ◽  
Yara Dadalti Fragoso
Keyword(s):  
Multiple Sclerosis ◽  
Neuropsychological Tests ◽  
Word List ◽  
Cognitive Domain ◽  
Healthy Controls ◽  
Factor Solution ◽  
Simple Method ◽  
Control Subjects ◽  
Relapsing Remitting ◽  
Repeatable Battery

To assess the cognition of patients with multiple sclerosis (MS) using the Rao's Brief Repeatable Battery of Neuropsychological Tests (BRB-N). METHOD: BRB-N was translated and adapted for control subjects. Subsequently, it was applied to a group of patients with relapsing-remitting (RR) MS. RESULTS: The assessment on the healthy controls (n=47) showed that the correlation between tests on the same cognitive domain was high and that there was a five-factor solution that explained 90% of the total variance. Except for the Word List Generation subset of tests, the performance of patients with RRMS (n=39) was worse than that of the healthy controls. CONCLUSION: BRB-N is a relatively simple method to assess cognition of patients with MS in the daily clinic. It does not take long to apply and does not require special skills or equipment.

scholarly journals Normative values of the Brief Repeatable Battery of Neuropsychological Tests in a Brazilian population sample: discrete and regression–based norms

2018 ◽  
Vol 76 (3) ◽  
pp. 163-169 ◽  
Author(s):  
Alfredo Damasceno ◽  
Juliana Machado Santiago dos Santos Amaral ◽  
Amilton Antunes Barreira ◽  
Jefferson Becker ◽  
Dagoberto Callegaro ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Educational Level ◽  
Neuropsychological Tests ◽  
Normative Data ◽  
Population Sample ◽  
Brazilian Population ◽  
Normative Values ◽  
Healthy Individuals ◽  
Repeatable Battery ◽  
Healthy Participants

ABSTRACT Objective Cognitive dysfunction is common in multiple sclerosis. The Brief Repeatable Battery of Neuropsychological Tests (BRB–N) was developed to assess cognitive functions most–frequently impaired in multiple sclerosis. However, normative values are lacking in Brazil. Therefore, we aimed to provide continuous and discrete normative values for the BRB–N in a Brazilian population sample. Methods We recruited 285 healthy individuals from the community at 10 Brazilian sites and applied the BRB–N version A in 237 participants and version B in 48 participants. Continuous norms were calculated with multiple–regression analysis. Results Mean raw scores and the 5th percentile for each neuropsychological measure are provided, stratified by age and educational level. Healthy participants' raw scores were converted to scaled scores, which were regressed on age, sex and education, yielding equations that can be used to calculate predicted scores. Conclusion Our normative data allow a more widespread use of the BRB–N in clinical practice and research.

scholarly journals Evaluation of the effects of group psychotherapy on cognitive function in patients with multiple sclerosis with cognitive dysfunction and depression

2015 ◽  
Vol 73 (2) ◽  
pp. 90-95 ◽  
Author(s):  
Emine Bilgi ◽  
Hasan Hüseyin Özdemir ◽  
Ayhan Bingol ◽  
Serpil Bulut
Keyword(s):  
Multiple Sclerosis ◽  
Cognitive Impairment ◽  
Cognitive Function ◽  
Group Psychotherapy ◽  
Cognitive Dysfunction ◽  
Beck Depression Inventory ◽  
Neuropsychological Tests ◽  
Depression Severity ◽  
Group Members ◽  
Repeatable Battery

Objective This study will evaluate how decreasing depression severity via group psychotherapy affects the cognitive function of patients with multiple sclerosis (MS) who are also diagnosed with depression and cognitive dysfunction. Method MS patients completed the Brief Repeatable Battery of Neuropsychological Tests and Beck Depression Inventory (BDI). The group members diagnosed with depression and cognitive dysfunction underwent group psychotherapy for 3 months. Upon completion of psychotherapy, both tests were readministered. Results Depression and cognitive dysfunction were comorbid in 15 (13.9%) of patients. Although improvement was detected at the end of the 3-month group psychotherapy intervention, it was limited to the BDI and the Paced Auditory Test. Conclusion Group psychotherapy might decrease cognitive impairment in MS patients.

Comparison of two brief neuropsychological batteries in people with multiple sclerosis

2002 ◽  
Vol 8 (2) ◽  
pp. 169-176 ◽  
Author(s):  
A Solari ◽  
L Mancuso ◽  
A Motta ◽  
L Mendozzi ◽  
C Serrati
Keyword(s):  
Multiple Sclerosis ◽  
Cognitive Impairment ◽  
Poor Performance ◽  
Clinical Variable ◽  
Impaired Performance ◽  
Selective Reminding ◽  
Administration Time ◽  
Serial Addition ◽  
The Relationship ◽  
Serial Evaluation

Background: We compared two brief neuropsychological batteries devised to assess people with multiple sclerosis (MS) and used them to assess the relationship between cognitive impairment and clinical characteristics. Methods: We administered either the Brief Repeatable Battery of Neuropsychological Tests (BRBNT) or the Screening Examination for Cognitive Impairment (SEFCI) to 213 consecutive MS outpatients and 213 individually matched controls. Results: Administration times were longer for BRBNT than SEFCI, for MS and controls (p=0.001). People with MS had lower scores in all individual tests than controls (p<0.001, BRBNT and SEFCI). By the criterion of poor performance on one or more tests, the sensitivity of BRBNT was 41.9% and that of SEFCI 31.5%. The corresponding figures by poor performance on two or more tests were 16.2% for BRBNT and 18.5% for SEFCI. The Buschke Selective Reminding and Paced Auditory Serial Addition were the tests best discriminating between people with MS and controls for BRBNT, and the Symbol Digit Modalities test for SEFCI. The only clinical variable independently associated with impaired performance on these batteries was EDSS. Conclusions: Both cognitive batteries were well accepted and easy to administer. Administration time for SEFCI was significantly shorter than for BRBNT; however, alternative forms for serial evaluation are available only for BRBNT. The BRBNT was slightly more sensitive in detecting impairment by the criterion of poor performance on one or more tests. EDSS score was the only clinical variable independently associated with cognitive impairment.

scholarly journals KOGNITYVINIO FUNKCIONAVIMO IR DEPRESIŠKUMO RYŠYS SERGANT IŠSĖTINE SKLEROZE: TRUMPO DAUGIAKARČIO NEUROPSICHOLOGINIŲ TESTŲ RINKINIO TAIKYMAS LIETUVOJE

Psichologija ◽  
2005 ◽  
Vol 32 ◽  
pp. 74-86 ◽  
Author(s):  
Ramunė Grambaitė ◽  
Rūta Sargautytė
Keyword(s):  
Multiple Sclerosis ◽  
Information Processing ◽  
Cognitive Function ◽  
Processing Speed ◽  
Neuropsychological Tests ◽  
Verbal Learning ◽  
Depression Severity ◽  
Information Processing Speed ◽  
Repeatable Battery ◽  
The Relationship

Nors susirgus išsėtine skleroze (IS) 40–70% žmonių sutrinka kognityvinis funkcionavimas, o depresija taip pat dažnai lydi IS (nustatoma 27–54% sergančiųjų), duomenys apie jų sąryšį gana prieštaringi. Straipsnyje analizuojamas kognityvinio funkcionavimo ir depresiškumo ryšys sergant išsėtine skleroze ir Trumpo daugiakarčio neuropsichologinių testų rinkinio (BRBNT) taikymo galimybės. Tyrime dalyvavo 41 žmogus, sergantis IS, ir 52 sveiki asmenys. Kognityvinėms funkcijoms vertinti buvo išversta ir naudojama BRBNT B versija (Rao and Peyser, 1986). Depresiškumui vertinti buvo taikomas Becko depresijos inventarijus (BDI-II). Gauti rezultatai rodo, jog sergančiųjų IS verbalinis išmokimas yra neigiamai susijęs su depresiškumu: depresiškumas statistiškai reikšmingai koreliuoja su pastovaus ilgalaikio atgaminimo rodikliais ir su ilgalaikiu atgaminimu po tam tikro uždelsimo laikotarpio, tačiau hipotezė, jog egzistuoja ryšys tarp informacijos apdorojimo greičio ir depresiškumo, nepasitvirtino. Klasifikuojant tiriamuosius į sveikus ir sergančius IS, gautas 100% BRBNT jautrumas, taip pat 100% specifiškumas.Pagrindiniai žodžiai: išsėtinė sklerozė, kognityvinis funkcionavimas, depresiškumas. THE RELATIONSHIP BETWEEN COGNITIVE FUNCTION AND DEPRESSION SEVERITY IN MULTIPLE SCLEROSIS PATIENTS: APPLICATION OF THE BRIEF REPEATABLE BATTERY OF NEUROPSYCHOLOGICAL TESTS (BRBNT) IN LITHUANIARamunė Grambaitė, Rūta Sargautytė SummaryMultiple sclerosis (MS) is an inflammatory and neurodegenerative disorder that affects primarily the cerebral white matter, thereby causing both physical and psychological disability. The purpose of this study was to investigate the possible relationship between cognitive function and depression severity in MS patients, as well as sensitivity and specificity characteristics of the BRBNT (The Brief Repeatable Battery of Neuropsychological Tests). We investigated 41 MS patients and 52 healthy people.Forty-one controls were selected from fifty-two healthy subjects and were individually matched with MS subjects for age, gender and education. BRBNT (Rao and Peyser, 1986) was designed for measuring verbal learning, visuospatial learning, sustained attention and concentration, information processing speed and verbal fluency cognitive functions. The B version of the BRBNT was translated and used in our study. Beck Depression Inventory-Second Edition (BDI-II) (Beck, 1996) was used for the evaluation of depression severity.Results of our study confirmed that depression severity was associated with verbal learning: Consistent Long Term Retrieval and the Delayed Recall significantly negatively related to depression severity. The relationship between information processing speed and depression severity was also negative, but not statistically significant. The five individual BRBNT tests separately did not significantly discriminate healthy controls from MS patients; however, when all the five BRBNT tests put together we found 100% sensitivity of and 100% specificity.Our findings lead to the conclusion that neuropsychological testing is important in organizing help strategies for MS patients. BRBNT is a sensitive measure of cognitive function in MS, and may assist with differential diagnosis. Similarly, BRBNT could well be applied to other groups of patients, whose illness results in physical and/or cognitive functional limitations.Keywords: multiple sclerosis, cognitive function, depression severity.

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