Oseltamivir and acute hepatitis, reality association or coincidence?

2021 ◽  
pp. 135965352110414
Author(s):  
Antonio Mastroianni ◽  
Valeria Vangeli ◽  
Sonia Greco ◽  
Filippo Urso ◽  
Francesca Greco ◽  
...  
Keyword(s):  
Side Effects ◽  
Acute Hepatitis ◽  
Influenza A ◽  
Product Label ◽  
H1n1 Infection ◽  
Review Of The Literature ◽  
Extensive Search ◽  
Pubmed Database ◽  
Antiviral Medication ◽  
Influenza H1n1

Oseltamivir is an orally administered antiviral medication that selectively inhibits the influenza neuraminidase enzymes that are essential for viral replication and it is active against both influenza A and B viruses. Oseltamivir is indicated for therapy or post-exposure prevention of influenza A and B. Side effects are uncommon and include mild nausea, gastrointestinal upset, dizziness, and headache. Despite widespread use, oseltamivir has not been associated with clinically apparent liver injury; however, there is growing evidence of possible toxic liver involvement during oseltamivir therapy. To the best of our knowledge, this is the first reported case in Italy linking the development of acute hepatitis and oseltamivir therapy, in a patient suffering from influenza H1N1 infection. We also present a review of the literature on cases of oseltamivir hepatotoxicity, through the consultation of PubMed database, the bibliographical references of various articles and an extensive search using Google. In view of the analyzed results, we suggest that experts should carefully consider the need for inclusion of potential serious liver reactions be added to the oseltamivir product label.

scholarly journals Comparison of Immunoglobulin G Subclass Concentrations in Severe Community-Acquired Pneumonia and Severe Pandemic 2009 Influenza A (H1N1) Infection

2012 ◽  
Vol 19 (3) ◽  
pp. 446-448 ◽  
Author(s):  
Claire L. Gordon ◽  
Natasha E. Holmes ◽  
M. Lindsay Grayson ◽  
Joseph Torresi ◽  
Paul D. R. Johnson ◽  
...  
Keyword(s):  
Immunoglobulin G ◽  
Influenza A ◽  
H1n1 Virus ◽  
Community Acquired Pneumonia ◽  
H1n1 Infection ◽  
Influenza A H1n1 ◽  
Severe Community Acquired Pneumonia ◽  
Immunoglobulin G Subclass ◽  
Influenza H1n1 ◽  
H1n1 Virus Infection

ABSTRACTWe compared immunoglobulin G (IgG) subclasses in patients with severe noninfluenza community-acquired pneumonia (CAP) to those in patients with severe pandemic 2009 influenza (H1N1) virus infection. Low IgG1 and IgG2 levels occurred often in the CAP group; however, H1N1 patients had lower IgG1 and IgG2 levels (5.4 versus 3.3 g/liter [P= 0.008] and 2.5 versus 1.2 g/liter [P< 0.001], respectively). Low IgG2 levels may be specifically linked to severe H1N1; however, it is not clear whether this association is related to H1N1 or to other features of severity.

scholarly journals Acute kidney injury in a critically ill influenza: a H1N1 infected child

2019 ◽  
Vol 6 (4) ◽  
pp. 1760
Author(s):  
Dinesh Kumar Jayapalan ◽  
Sangeetha Geminiganesan ◽  
Shruthi Parthasarathy ◽  
Niranjana Varadharaju ◽  
Nithya Bhaskar
Keyword(s):  
Acute Kidney Injury ◽  
Influenza A ◽  
Pediatric Population ◽  
Kidney Injury ◽  
Pulmonary Complications ◽  
H1n1 Infection ◽  
Influenza A H1n1 ◽  
Extra Pulmonary ◽  
First Time ◽  
Influenza H1n1

Influenza H1N1 infection is a globally recognized epidemic and is known for several extra-pulmonary complications. Here, for the first time we report a case of a six-year old male child with severe H1N1 infection with acute kidney injury. The child was referred to our center with fever, chills, cough and cold for 2 days. Investigations revealed H1N1 infection with deranged LFT and RFT with anuria. Child was subjected to mechanical ventilation and received higher antibiotics in addition to oseltamivir. The child underwent 13 cycles of hemodialysis and renal profile normalized after a period of 35 days. Our case highlights the importance of recognizing extra-pulmonary complications of H1N1 infection in the pediatric population and the preparation required by healthcare practitioners to reduce the associated mortality.

Long-term side effects following pneumonectomy: A case report and review of the literature

2019 ◽  
Author(s):  
BA Högerle ◽  
EL Bulut ◽  
L Klotz ◽  
F Eichhorn ◽  
M Eichhorn ◽  
...  
Keyword(s):  
Case Report ◽  
Side Effects ◽  
Review Of The Literature

scholarly journals Systematic Review of the Role of BCG in the Treatment of Urothelial Carcinoma of the Prostatic Urethra

2021 ◽  
pp. 1-8
Author(s):  
Oliver Patschan ◽  
Philippe E. Spiess ◽  
George N. Thalmann ◽  
Joan Palou Redorta ◽  
Georgios Gakis
Keyword(s):  
Side Effects ◽  
Urothelial Carcinoma ◽  
Evidence Synthesis ◽  
Tnm Classification ◽  
Transitional Cell ◽  
Prostatic Urethra ◽  
Local Response ◽  
Pubmed Database ◽  
Bcg Therapy ◽  
Tumor Stages

BACKGROUND: In patients with non-invasive urothelial carcinoma of the prostatic urethra (PUC), treatment with Bacillus Calmette-Guárin (BCG) could be beneficial. OBJECTIVE: To assess the response rates to BCG in the different tumor stages, to describe the clinical impact of transurethral resection of the prostate (TURP) before BCG treatment, and to review the side effects of BCG treatment for PUC. METHODS: A systematic search was conducted using the PubMed database to identify original studies between 1977 and 2019 reporting on PUC and BCG. RESULTS: Of a total of 865 studies, ten were considered for evidence synthesis. An indication for BCG treatment was found in non-stromal invasive stages (Tis pu, Tis pd) and in stromal infiltrating cases (T1) of primary and secondary PUC when transitional cell carcinoma was the histology of origin. Studies including patients treated with TURP before BCG showed a better local response in the prostatic urethra with a higher DFS (80–100% vs. 63–89%) and PFS (90–100% vs. 75–94%) than patients in studies in which no TURP was performed. However, this difference in recurrence and progression in the prostate neither affected the total PFS (57–75% vs. 58–93%), nor the disease specific survival (70–100% vs. 66–100%). CONCLUSIONS: The use of resection loop biopsies of the prostatic urethra in appropriate cases during the primary work-up for suspected PUC, as well as the use of the current TNM classification for PUC, need to be improved. BCG therapy for non-stromal invasive stages of PUC show a good local response. Local response is further improved by a TURP before BCG therapy, although the overall prognosis does not seem to be affected. Further evidence for BCG treatment in the rare cases of stromal invasive PUC is needed. Specific side effects of BCG treatment for PUC are not reported.

Nosocomial Influenza in a Pediatric Hospital: Comparison of Rates of Seasonal and Pandemic 2009 Influenza A/H1N1 Infection

2012 ◽  
Vol 33 (3) ◽  
pp. 292-294 ◽  
Author(s):  
Gholamabbas Amin Ostovar ◽  
Nina Kohn ◽  
Karl O. A. Yu ◽  
Susan Nullet ◽  
Lorry G. Rubin
Keyword(s):  
Influenza A ◽  
Infect Control Hosp ◽  
H1n1 Infection ◽  
Pediatric Hospital ◽  
Children's Hospital ◽  
Influenza A H1n1 ◽  
Children’S Hospital ◽  
Hospital Comparison

The rates of nosocomial seasonal (January 2008 to March 2009) and 2009 A/H1N1 (April 2009 to December 2010) influenza infections in a children's hospital were compared. Droplet precautions were used. The rates were similar during both periods, suggesting that use of droplet precautions did not result in a higher rate of influenza A/H1N1 infection.Infect Control Hosp Epidemiol 2012;33(3):292-294

Modeling and simulation of the spread of H1N1 flu with periodic vaccination

2015 ◽  
Vol 09 (01) ◽  
pp. 1650003 ◽  
Author(s):  
Islam A. Moneim
Keyword(s):  
Influenza A ◽  
Vaccination Strategy ◽  
Vaccination Rate ◽  
Influenza Viruses ◽  
Sirs Epidemic Model ◽  
Sirs Model ◽  
Influenza A H1n1 ◽  
Large Populations ◽  
Stability Results ◽  
Influenza H1n1

Influenza H1N1 has been found to exhibit oscillatory levels of incidence in large populations. Clear peaks for influenza H1N1 are observed in several countries including Vietnam each year [M. F. Boni, B. H. Manh, P. Q. Thai, J. Farrar, T. Hien, N. T. Hien, N. Van Kinh and P. Horby, Modelling the progression of pandemic influenza A (H1N1) in Vietnam and the opportunities for reassortment with other influenza viruses, BMC Med. 7 (2009) 43, Doi: 10.1186/1741-7015-7-43]. So it is important to study seasonal forces and factors which can affect the transmission of this disease. This paper studies an SIRS epidemic model with seasonal vaccination rate. This SIRS model has a unique disease-free solution (DFS). The value R0, the basic reproduction number is obtained when the vaccination is a periodic function. Stability results for the DFS are obtained when R0 < 1. The disease persists in the population and remains endemic if R0 > 1. Also when R0 > 1 existence of a nonzero periodic solution is proved. These results obtained for our model when the vaccination strategy is a non-constant time-dependent function.

Acute Renal Failure Caused by Imiquimod 5% Cream in a Renal Transplant Patient: Review of the Literature on Side Effects of Imiquimod

Dermatology ◽  
2011 ◽  
Vol 222 (2) ◽  
pp. 109-112 ◽  
Author(s):  
J. Santos-Juanes ◽  
A. Esteve ◽  
A. Mas-Vidal ◽  
P. Coto-Segura ◽  
E. Salgueiro ◽  
...  
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Side Effects ◽  
Renal Transplant ◽  
Renal Transplant Patient ◽  
Transplant Patient ◽  
Review Of The Literature

scholarly journals Influenza A(H1N1) infection and severe cardiac dysfunction in adults: A case series

2011 ◽  
Vol 123 (3-4) ◽  
pp. 120-123 ◽  
Author(s):  
Jan A. Wiegand ◽  
Christian Torgersen ◽  
Stefan Bloechlinger ◽  
Jukka Takala ◽  
Martin W. Dünser
Keyword(s):  
Cardiac Dysfunction ◽  
Influenza A ◽  
Case Series ◽  
H1n1 Infection ◽  
Influenza A H1n1
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