scholarly journals The Rationale of Surgical Treatment of Invasive Breast Cancer and Decision Making of Surgical Procedures

2002 ◽  
Vol 91 (3) ◽  
pp. 240-245 ◽  
Author(s):  
L. Bergkvist
Keyword(s):  
Breast Cancer ◽  
Breast Surgery ◽  
Postoperative Radiotherapy ◽  
Rapid Development ◽  
Breast Conserving Therapy ◽  
Primary Treatment ◽  
Axillary Clearance ◽  
Axillary Surgery ◽  
Node Biopsy

Surgery plays a major role in the primary treatment of breast cancer. There has been rapid development in breast surgery over the last 20 years. Breast conserving therapy is standard today for tumours up till 4 cm in diameter, and can be used in selected cases for larger tumours after preoperative down staging with chemotherapy. Breast conserving therapy with postoperative radiotherapy gives the same long-term overall survival as mastectomy. Axillary surgery has also developed conservatively, with the introduction of the new technique of sentinel node biopsy, which offers an alternative to axillary clearance for staging of the axilla, with less morbidity.

Sentinel node biopsy in patients with breast cancer and previous breast surgery

2011 ◽  
Vol 30 (4) ◽  
pp. 223-228
Author(s):  
I. Blanco ◽  
D. Díaz ◽  
C. Moriyón ◽  
L. Santamaría ◽  
M.A. Díez ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Sentinel Node ◽  
Sentinel Node Biopsy ◽  
Breast Surgery ◽  
Node Biopsy

scholarly journals Breast cancer patient-reported outcome of factors influencing cosmetic satisfaction after breast-conserving therapy

Breast Cancer ◽  
2021 ◽  
Author(s):  
A. T. P. M. Brands-Appeldoorn ◽  
A. J. G. Maaskant-Braat ◽  
L. Janssen ◽  
L. A. D. M. van Osch ◽  
V. C. G. Tjan-Heijnen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Body Image ◽  
Breast Surgery ◽  
Breast Conserving Therapy ◽  
Patient Reported Outcome ◽  
Breast Size ◽  
Exclusion Criteria ◽  
Non Invasive ◽  
Patient Reported ◽  
Relevant Factors

Abstract Background The aim of this study was to investigate which factors patients considered to be important for determining the degree of cosmetic satisfaction with regards to perceived body image after previous breast-conserving therapy (BCT). Methods Outcomes considered relevant by the patients were first identified using interviews. A questionnaire based on this group input was then devised and added to the physician-based Sneeuw questionnaire. Next, a quantitative study using this questionnaire was conducted in Dutch patients treated at least 6 months earlier for (non-) invasive breast cancer by BCT. Exclusion criteria were: previous mastectomy or BCT of the contralateral breast, BCT with nipple resection, metastatic disease, local recurrence or (previous) plastic breast surgery. Descriptive statistics were used throughout. Results A total of 149 patients (aged 36–87 years) completed the questionnaire. From this focus group input, the top three factors in overall importance (important or very important) for satisfaction were: ‘wearability of bra’ (67%), ‘breast sensitivity’ (59%) and ‘asymmetry’ (51%). Younger patients (< 55 years) considered ‘breast size’ to be most important, whereas ‘wearability of bra’ was most frequently reported by older patients (> 55 years). Time since BCT did not significantly influence the rating of relevant factors. Conclusion Patients consider ‘wearability of bra’, ‘breast sensitivity’ and ‘asymmetry’ as the most important factors when assessing their satisfaction with regards to cosmetic outcome and body image. These factors should be addressed in routine clinical practice during (pre) counseling.

scholarly journals Avoiding Axillary Sentinel Lymph Node Biopsy after Neoadjuvant Systemic Therapy in Breast Cancer: Rationale for the Prospective, Multicentric EUBREAST-01 Trial

Cancers ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 3698
Author(s):  
Toralf Reimer ◽  
Aenne Glass ◽  
Edoardo Botteri ◽  
Sibylle Loibl ◽  
Oreste D. Gentilini
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Sentinel Lymph Node Biopsy ◽  
Systemic Therapy ◽  
Lymph Node Biopsy ◽  
Biological Behavior ◽  
Axillary Surgery ◽  
Node Biopsy ◽  
Neoadjuvant Systemic Therapy

Currently, axillary surgery for breast cancer is considered only as staging procedure, since the risk of developing metastasis depends on the biological behavior of the primary. The postsurgical therapy should be considered on the basis of biologic tumor characteristics rather than nodal involvement. Improvements in systemic treatments for breast cancer have increased the rates of pathologic complete response (pCR) in patients receiving neoadjuvant systemic therapy (NAST), offering the opportunity to de-escalate surgery in patients who have a pCR. European Breast Cancer Research Association of Surgical Trialists (EUBREAST)-01 is a clinical trial in which only patients with the highest likelihood of having a pCR after NAST (triple-negative or HER2-positive breast cancer) will be included and type of surgery will be defined according to the response to NAST rather than on the classical T (for tumor size in the breast) and N (for axillary lymph node involvement) status. In the discussed trial, axillary surgery will be eliminated completely (no axillary sentinel lymph node biopsy) for initially clinical node-negative (cN0) patients with radiologic complete remission and a breast pCR in the lumpectomy specimen. The trial design is a multicenter single-arm study with a limited number of patients (n = 267), which might give practice-changing results in a short period of time, sparing the time and the costs of a randomized comparison.

Breast-Conserving Therapy in Patients with a Relatively Large (T2 or T3) Breast Cancer: Long-Term Local Control and Cosmetic Outcome of a Feasibility Study

2004 ◽  
Vol 113 (6) ◽  
pp. 1607-1616 ◽  
Author(s):  
Leonie A. E. Woerdeman ◽  
J. Joris Hage ◽  
Esther A. Thio ◽  
Frans A. N. Zoetmulder ◽  
Emiel J. Th. Rutgers
Keyword(s):  
Breast Cancer ◽  
Feasibility Study ◽  
Local Control ◽  
Breast Conserving Therapy ◽  
Cosmetic Outcome
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