Associations between the angiotensin-converting enzyme insertion/deletion polymorphism and susceptibility to vasculitis: a meta-analysis

Introduction: To explore whether the insertion (I) and deletion (D) polymorphism of angiotensin-converting enzyme ( ACE) confers susceptibility to vasculitis. Materials and methods: A meta-analysis was conducted on the associations between the ACE I/D polymorphism and vasculitis. Results: Twelve studies, including four on Behçet’s disease (BD), four on Henoch–Schenlein purpura (HSP), three on Kawasaki disease (KD), and one on Wegener’s granulomatosis, were available for the meta-analysis. Meta-analysis showed that the DD + ID genotype was associated with susceptibility to vasculitis (odds ratio [OR] 1.468, 95% confidence interval [CI] 1.214–1.468, p = 7.4 × 10−5). The overall OR for the D allele was significantly increased in BD (OR 1.313, 95% CI 1.017–1.695). Meta-analysis of the DD+ID genotype, the DD genotype and the DD vs. II genotype showed marginal associations with BD, but meta-analysis of the D allele, and the DD+ID genotype showed significant associations with HSP (OR 1.446, 95% CI 1.021–2.049, p = 0.038; OR 1.881, 95% CI 1.385–2.595, p = 6.6 × 10−5). On the other hand, meta-analysis showed no association between KD and the ACE I/D polymorphism. Conclusions: This meta-analysis shows that the ACE I/D polymorphism is associated with vasculitis susceptibility, especially in BD and HSP.

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Angiotensin-converting enzyme insertion/deletion polymorphism and susceptibility to Henoch–Schönlein purpura: a meta-analysis

Journal of the Renin-Angiotensin-Aldosterone System ◽

10.1177/1470320319836302 ◽

2019 ◽

Vol 20 (1) ◽

pp. 147032031983630 ◽

Cited By ~ 1

Author(s):

Xiaoqing Zhang ◽

Lin Wu ◽

Minglei Chai ◽

Xiaofang Huang ◽

Jiajin Zhu ◽

...

Keyword(s):

Confidence Interval ◽

Angiotensin Converting Enzyme ◽

Odds Ratio ◽

Meta Analysis ◽

Asian Population ◽

Converting Enzyme ◽

Henoch Schonlein Purpura ◽

Deletion Polymorphism ◽

Schonlein Purpura ◽

Henoch Schönlein Purpura

Objective: Meta-analysis was performed in the current study to evaluate the relationship of the angiotensin-converting enzyme insertion/deletion polymorphism with the risk of the incidence of Henoch–Schönlein purpura. Methods: The electronic databases, including Embase, PubMed and Google scholar, were systemically retrieved to search for related articles. Meanwhile, statistical analysis was performed using the odds ratio and the corresponding 95% confidence interval. Results: A total of six articles enrolling 504 patients and 706 healthy controls was enrolled into the current meta-analysis. Results of the meta-analysis suggested that the angiotensin-converting enzyme D allele was markedly correlated with the risk of the incidence of Henoch–Schönlein purpura among the general population (deletion (D) vs. insertion (I): odds ratio (OR) 1.42, 95% confidence interval (CI) 1.05–1.93; DD vs. II: OR 2.23, 95% CI 1.06–4.70; DI vs. II: OR 1.36, 95% CI 1.00–1.85; dominant model: OR 1.56, 95% CI 1.00–2.42; recessive model: OR 1.83, 95% CI 1.06–3.16). Moreover, such a polymorphism was found to correlate with the susceptibility to Henoch–Schönlein purpura when studies were stratified according to the sample size of over 200. In addition, such a polymorphism was recognised to be remarkably associated with the susceptibility to Henoch–Schönlein purpura in the Caucasian population, which was not found in the Asian population. Conclusions: The results of the current meta-analysis indicate that the angiotensin-converting enzyme D allele might be a risk factor against the risk of Henoch–Schönlein purpura, especially in Caucasians.

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