The angiotensin-converting enzyme insertion/deletion polymorphism and susceptibility to rheumatoid arthritis, vitiligo and psoriasis: A meta-analysis

Objective: The correlation of the angiotensin-converting enzyme ( ACE) insertion/deletion (I/D) polymorphism with pediatric asthma risk was assessed in this meta-analysis. Methods: PubMed, Web of Science, Embase and CNKI databases were systematically searched for relevant literature, followed by application of odds ratios (OR) along with 95% confidence interval (CI) for determining the strength of relationship. Results: Seven articles with 802 cases and 632 controls fulfilled the inclusion criteria. As a result, the ACE I/D polymorphism was related to elevated pediatric asthma risk (D vs I: OR = 1.87, 95% CI = 1.59–2.20; dominant model: OR =1.53, 95% CI = 1.28–1.81; recessive model: OR =1.54, 95% CI = 1.28–1.85; DD vs II: OR =2.95, 95% CI = 2.19–3.98; DI vs II: OR = 0.96, 95% CI = 0.78–1.19). Subgroup analysis stratified by race revealed significant interrelation in Asians. Conclusion: This meta-analysis demonstrated that the ACE I/D polymorphism might be related to the risk of pediatric asthma.

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Associations between the angiotensin-converting enzyme insertion/deletion polymorphism and susceptibility to vasculitis: a meta-analysis

Journal of the Renin-Angiotensin-Aldosterone System ◽

10.1177/1470320311434240 ◽

2012 ◽

Vol 13 (1) ◽

pp. 196-201 ◽

Cited By ~ 15

Author(s):

Young Ho Lee ◽

Sung Jae Choi ◽

Jong Dae Ji ◽

Gwan Gyu Song

Keyword(s):

Kawasaki Disease ◽

Confidence Interval ◽

Angiotensin Converting Enzyme ◽

Odds Ratio ◽

Meta Analysis ◽

Wegener's Granulomatosis ◽

The Other ◽

Converting Enzyme ◽

Deletion Polymorphism ◽

Other Hand

Introduction: To explore whether the insertion (I) and deletion (D) polymorphism of angiotensin-converting enzyme ( ACE) confers susceptibility to vasculitis. Materials and methods: A meta-analysis was conducted on the associations between the ACE I/D polymorphism and vasculitis. Results: Twelve studies, including four on Behçet’s disease (BD), four on Henoch–Schenlein purpura (HSP), three on Kawasaki disease (KD), and one on Wegener’s granulomatosis, were available for the meta-analysis. Meta-analysis showed that the DD + ID genotype was associated with susceptibility to vasculitis (odds ratio [OR] 1.468, 95% confidence interval [CI] 1.214–1.468, p = 7.4 × 10−5). The overall OR for the D allele was significantly increased in BD (OR 1.313, 95% CI 1.017–1.695). Meta-analysis of the DD+ID genotype, the DD genotype and the DD vs. II genotype showed marginal associations with BD, but meta-analysis of the D allele, and the DD+ID genotype showed significant associations with HSP (OR 1.446, 95% CI 1.021–2.049, p = 0.038; OR 1.881, 95% CI 1.385–2.595, p = 6.6 × 10−5). On the other hand, meta-analysis showed no association between KD and the ACE I/D polymorphism. Conclusions: This meta-analysis shows that the ACE I/D polymorphism is associated with vasculitis susceptibility, especially in BD and HSP.

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