scholarly journals Fasting plasma triglyceride concentration: A possible approach to identify increased risk of statin-induced type 2 diabetes

2015 ◽  
Vol 12 (5) ◽  
pp. 373-376 ◽  
Author(s):  
Ki-Chul Sung ◽  
Gerald Reaven
Keyword(s):  
Type 2 Diabetes ◽  
Plasma Triglyceride ◽  
Plasma Triglyceride Concentration ◽  
Triglyceride Concentration ◽  
Fasting Plasma ◽  
Increased Risk

scholarly journals Acute hypoglycemia and risk of cardiac arrhythmias in insulin-treated type 2 diabetes and controls

2021 ◽  
Author(s):  
Andreas Andersen ◽  
Jonatan I Bagger ◽  
Maria Pa Baldassarre ◽  
Mikkel B. Christensen ◽  
Kirsten U Abelin ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Plasma Glucose ◽  
Fasting Plasma Glucose ◽  
Cardiac Arrhythmias ◽  
Hyperinsulinemic Hypoglycemia ◽  
Cardiac Repolarization ◽  
Counterregulatory Hormones ◽  
Fasting Plasma ◽  
Increased Risk

Objective. Hypoglycemia is associated with increased risk of cardiovascular disease including cardiac arrhythmias. We investigated the effect of hypoglycemia in the setting of acute glycemic fluctuations on cardiac rhythm and cardiac repolarization in insulin-treated patients with type 2 diabetes compared with matched controls without diabetes. Design. A non-randomised, mechanistic intervention study Methods. Insulin-treated patients with type 2 diabetes (n=21, [mean±SD] age 62.8±6.5 years, BMI 29.0±4.2 kg/m2, HbA1c 6.8±0.5% [51.0±5.4 mmol/mol]) and matched controls (n=21, age 62.2±8.3 years, BMI 29.2±3.5 kg/m2, HbA1c 5.3±0.3% [34.3±3.3 mmol/mol]) underwent a sequential hyperglycemic and hypoglycemic clamp with three steady-states of plasma glucose: 1) fasting plasma glucose, 2) hyperglycemia (fasting plasma glucose+10 mmol/L) and 3) hyperinsulinemic hypoglycemia (plasma glucose<3.0 mmol/L). Participants underwent continuous ECG monitoring and blood samples for counterregulatory hormones and plasma potassium were obtained. Results. Both groups experienced progressively increasing heart rate corrected QT (Fridericia’s formula)) interval prolongations during hypoglycemia ([∆mean (95% CI)] 31 ms [16, 45] and 39 ms [24, 53] in the group of patients with type 2 diabetes and controls, respectively) with similar increases from baseline at the end of the hypoglycemic phase (P=0.43). The incidence of ventricular premature beats increased significantly in both groups during hypoglycemia (P=0.033 and P<0.0001, respectively). One patient with type 2 diabetes developed atrial fibrillation during recovery from hypoglycemia. Conclusions. In insulin-treated patients with type 2 diabetes and controls without diabetes, hypoglycemia causes clinically significant and similar increases in cardiac repolarization that might increase vulnerability for serious cardiac arrythmias and sudden cardiac death.

scholarly journals Codon-54 Polymorphism of the Fatty Acid-Binding Protein 2 Gene Is Associated with Elevation of Fasting and Postprandial Triglyceride in Type 2 Diabetes*

2000 ◽  
Vol 85 (9) ◽  
pp. 3155-3160 ◽  
Author(s):  
Angeliki Georgopoulos ◽  
Omer Aras ◽  
Michael Y. Tsai
Keyword(s):  
Type 2 Diabetes ◽  
Fatty Acid ◽  
Fatty Acid Binding Protein ◽  
Binding Protein ◽  
Plasma Triglyceride ◽  
Wild Type ◽  
Fatty Acid Binding ◽  
Acid Binding Protein ◽  
Fasting Plasma

Abstract Patients with type 2 diabetes are frequently dyslipidemic or hypertriglyceridemic. To assess whether increased intestinal triglyceride input leads to elevated fasting and postprandial triglycerides in type 2 diabetes, we used the codon 54 polymorphism of the fatty acid-binding protein 2 gene, which results in the substitution of threonine (Thr) for alanine and is associated with increased intestinal input of triglyceride. Of the 287 diabetic patients screened, 108 (37.6%) were heterozygous and 31 (10.8%) were homozygous for the Thr-54 allele. Mean (±sem) fasting plasma triglyceride levels in patients with the wild-type (n = 80), those heterozygous for the Thr-54 allele (n = 57), and those homozygous for it (n = 18) were 2.0 ± 0.09, 2.7 ± 0.20, and 3.8 ± 0.43 mmol/L, respectively. A linear relationship of mean fasting plasma triglyceride levels (r2 = 0.97) between the 3 groups was found. After fat ingestion, the postprandial area under the curve of plasma triglyceride (P = 0.025) and chylomicrons (Sf &gt; 400, P = 0.013) was higher in the Thr-54/Thr-54 (n = 6) than in the wild-type (n= 9). Our results are consistent with the hypothesis that, in type 2 diabetes, increased intestinal input of triglyceride can lead to elevated fasting and postprandial plasma triglycerides.

scholarly journals Association of Serum Creatinine Levels and Risk of Type 2 Diabetes Mellitus in Korea

2020 ◽  
Author(s):  
Do Kyeong Song ◽  
Hyejin Lee ◽  
Young Sun Hong ◽  
Yeon-Ah Sung
Keyword(s):  
Diabetes Mellitus ◽  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Serum Creatinine ◽  
Plasma Glucose ◽  
Fasting Plasma Glucose ◽  
Fasting Plasma ◽  
Increased Risk

Abstract Reduced skeletal muscle has been suggested as a risk factor for type 2 diabetes mellitus (T2DM). Serum creatinine is used as a surrogate for muscle mass. Therefore, low serum creatinine levels may be associated with an increased risk of T2DM. We aimed to evaluate the association between serum creatinine levels and the risk of T2DM. We analyzed a total of 264,832 nondiabetic adults in Korea. In men, serum creatinine levels and the risk for T2DM showed an inverse J-shaped association even after adjustment for age, body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), and fasting plasma glucose. In women, there was a trend that serum creatinine levels were inversely associated with the risk of T2DM among those with serum creatinine below 1.1 mg/dl. However, serum creatinine levels were not significantly associated with the risk of T2DM after adjustment for age, BMI, SBP, DBP, and fasting plasma glucose. Reduced levels of serum creatinine were significantly associated with an increased risk of T2DM in men with creatinine below 1.20 mg/dl. There was a trend that decreased levels of serum creatinine were associated with an increased risk of T2DM among women, although this result was not statistically significant.

Sign in / Sign up

Export Citation Format

Share Document