scholarly journals Ankle-brachial index and peripheral arterial disease: An evaluation including a type 2 diabetes mellitus drug-naïve patients cohort

2019 ◽  
Vol 16 (4) ◽  
pp. 344-350 ◽  
Author(s):  
João Soares Felício ◽  
Camila Cavalcante Koury ◽  
Nathalie Abdallah Zahalan ◽  
Fabrício de Souza Resende ◽  
Manuela Nascimento de Lemos ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Peripheral Arterial Disease ◽  
Ankle Brachial Index ◽  
Arterial Disease ◽  
Drug Naïve ◽  
Peripheral Arterial ◽  
Group 1

Background: Peripheral arterial disease in patients with type 2 diabetes mellitus is an important risk factor for vascular events. Recommendations about whether ankle-brachial index should be performed differ depending on the source; therefore, it is necessary to re-evaluate the most important risk factors associated with peripheral arterial disease and whether it is useful to perform ankle-brachial index in newly diagnosed and drug-naïve patients with diabetes, independent of age or peripheral arterial disease symptoms. Methods: A total of 711 subjects were divided into groups: group 1, 600 type 2 diabetes mellitus patients, symptomatic or not for peripheral arterial disease; group 2, 61 type 2 diabetes mellitus patients newly diagnosed and drug naïve; and group 3, 50 subjects without diabetes. Ankle-brachial index, medical records and physical examination were performed in all patients, accessing cardiovascular risk factors. Results: Analysing group 1 asymptomatic patient to peripheral arterial disease, we found abnormal ankle-brachial index in 49% (77/156) ⩾50 years and 42% (16/38) <50 years ( p = not significant). Considering drug-naïve patients, a peripheral arterial disease prevalence of 39% (24/61) was found; among these, 48% (13/27) were <50 years and 32% (11/34) were ⩾50 years ( p = not significant). A forward stepwise regression model was developed, with type 2 diabetes mellitus duration ( r2 = 0.12) and sedentary lifestyle ( r2 = 0.14) found as independent variable predictors of severity of peripheral arterial disease, related to ankle-brachial index. Conclusion: We suggest that, in type 2 diabetes mellitus, ankle-brachial index should be measured at diagnosis. In addition, sedentary lifestyle was strongly associated with presence and severity of peripheral arterial disease.

scholarly journals Penyakit Arteri Perifer dan Mortalitas Kardiovaskular pada Pasien Diabetes Melitus Tipe-2

2019 ◽  
Vol 6 (2) ◽  
pp. 100
Author(s):  
Em Yunir ◽  
Dekta Filantropi Esa ◽  
Adelia Nova Prahasary ◽  
Dicky Levenus Tahapary
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Peripheral Arterial Disease ◽  
Cardiovascular Mortality ◽  
Ankle Brachial Index ◽  
Arterial Disease ◽  
Peripheral Arterial ◽  
Diabetes Melitus

Peripheral arterial disease (PAD) merupakan salah satu komplikasi makrovaskular diabetes melitus tipe 2 (DMT2) yang dikaitkan dengan peningkatan risiko mortalitas kardiovaskular. Pemeriksaan ankle-brachial index (ABI) merupakan salah satu pemeriksaan yang sederhana dan mudah dilakukan untuk menegakkan diagnosis PAD. Oleh karena itu, penulis ingin mengetahui tingkat mortalitas kardiovaskular pasien DMT2 dengan PAD. Dari hasil penelusuran literatur, didapatkan tujuh literatur. Studi Bundo dkk melaporkan hasil HR 2,45 (interval kepercayaan [IK] 95%: 0,84-7,17). Studi Mostaza dkk melaporkan hasil HR 1,64 (IK 95%: 0,64-4,49). Studi Aboyans dkk melaporkan hasil HR 2,21 (IK 95%: 1,16-4,22). Studi Mohammedi dkk melaporkan hasil HR 1,35 (IK 95%: 1,15-1,60). Studi Quiles dkk melaporkan hasil HR 6,61 (IK 95%: 2,47-17,72). Studi Mueller dkk melaporkan hasil  RR 3,53 (IK 95%: 1,80-6,91). Studi lanjutan Mueller dkk melaporkan hasil  RR 4,06 (IK 95%: 2,67-6,18). Dari hasil studi tersebut, dapat disimpulkan bahwa pasien DMT2 yang disertai dengan PAD akan meningkatkan mortalitas kardiovaskular, serta nilai ABI dapat digunakan sebagai instrumen stratifikasi independen mortalitas kardiovaskularKata Kunci:Ankle brachial index, diabetes melitus tipe 2, mortalitas kardiovaskular, penyakit arteri perifer Peripheral Arterial disease and Cardiovascular Mortality in Type-2 Diabetes MellitusPeripheral arterial disease (PAD) is one of the macrovascular complications of type 2 diabetes mellitus (T2DM), which increases the risk of cardiovascular mortality. Ankle-brachial index (ABI) is one of the simple and widely available tool to diagnose PAD. The authors aim to find out the cardiovascular mortality in T2DM patient with PAD. Bundo et al. study found HR 2.45 (95% CI: 0.84 to 7.17). Mostaza et al. study reported HR 1.64 (95% CI: 0.64 to 4.49). Aboyans et al. study declared HR 2.21 (95% CI: 1.16 to 4.22). Mohammedi K et al. claimed HR 1.35 (95% CI: 1.15 to 1.60). Quiles et al. found HR 6.61 (95% CI: 2.47 to 17.72). Mueller et al. study reported  RR 3,53 (95% CI: 1.80 to 6.91). Mueller et al. study reported  RR 4,06 ( 95% CI: 2.67 to 6.18).  In conclusion, the mortality risk in T2DM patients with PAD is higher compared to those without PAD. Moreover, an ankle-brachial index can be used as an independent stratification tool to predict the risk of cardiovascular mortality

scholarly journals EFFECT OF LEG EXERCISE ON THE ANKLE BRACHIAL INDEX (ABI) OF TYPE 2 DIABETES MELLITUS PATIENTS IN REJANG LEBONG REGIONAL HOSPITAL

2021 ◽  
Vol 13 (2) ◽  
Author(s):  
Derison Marsinova Bakara ◽  
Kurniyati Kurniyati
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Peripheral Arterial Disease ◽  
Exercise Intervention ◽  
Ankle Brachial Index ◽  
Arterial Disease ◽  
Wilcoxon Test ◽  
Peripheral Arterial

Introduction: Peripheral arterial disease often occurs in patients with type 2 diabetes mellitus. Peripheral arterial disease in patients with type 2 diabetes mellitus occurs due to decreased blood circulation in the lower extremities. Looking at the value of the ankle-brachial index is one of the actions that can be taken to detect peripheral arterial disease. Objective: The purpose of this study was to determine the effect of a foot exercise intervention on the ankle-brachial index value of type 2 diabetes mellitus patients. Methods: This research was a quantitative research with a pre-experimental design, with one pre-test and post-test design. The research was carried out at Rejang Lebong Hospital from August to November 2020. The number of samples used in this study were 35 patients experiencing type 2 diabetes mellitus for more than five years. The analysis used in this study was the Wilcoxon test. Results: The results showed a difference in the mean of the ankle-brachial index before (1.02) and after (1.12) the intervention. Thus, there was an increase of 0.10 in the average value of the ankle-brachial index. The analysis result of this study showed the value of p = 0.001 (p<0.05). Conclusion: Foot exercise can be used as an alternative intervention to increase the value of the ankle-brachial index in patients with type 2 diabetes mellitus.

scholarly journals Serum Homocysteine Level in Type 2 Diabetes Mellitus with Peripheral Arterial Disease

2013 ◽  
Vol 6 (1) ◽  
pp. 14-18
Author(s):  
H Howlader ◽  
S Ahmed ◽  
N Sultana ◽  
Z Hasan ◽  
U Sadia ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Hydrogen Peroxide ◽  
Type 2 Diabetes Mellitus ◽  
Peripheral Arterial Disease ◽  
Ankle Brachial Index ◽  
Arterial Disease ◽  
Significant Difference ◽  
Peripheral Arterial

Peripheral arterial disease is a macrovascular complication of type 2 diabetes mellitus. Hyper-homocysteinemia is found to be associated with peripheral arterial disease. Homocysteine induced endothelial-cell injury is mediated by hydrogen peroxide. Hydrogen peroxide exposes the underlying matrix and smooth muscle cells of the arteries which, in turn, proliferate and promote the activation of platelets and leukocytes. The present study was carried out in the Department of Biochemistry, Dhaka Medical College, Dhaka from July 2010 to June 2011 to observe the association of hyperhomocysteinemia with peripheral arterial disease in type 2 diabetes mellitus. A total of 100 subjects (50 cases and 50 controls) were selected by purposive sampling from Bangladesh Institute of Health sciences (BIHS) and BIRDEM Hospital, Dhaka. Subjects having ankle brachial index <0.9 were considered as cases and those having ankle brachial index 0.9 were considered as controls. Subjects with absent peripheral pulses or nonrecordable ankle brachial index were considered as ankle brachial index <0.9. All study subjects were normotensive, normolipidemic and non- smoker. The study showed a higher level of homocysteine (?mol/L) in cases when compared with that of controls (15.95±1.80 vs. 9.31±2.11; p<0.001). In cases, males had higher proportion of arterial disease (56%) than females. Other variables (age and body mass index) showed no significant difference between two groups. DOI: http://dx.doi.org/10.3329/bjmb.v6i1.13282 Bangladesh J Med Biochem 2013; 6(1): 14-18

scholarly journals Estudio Descriptivo: Frecuencia y factores de riesgo de la enfermedad arterial periférica en pacientes con Diabetes Mellitus II del Hospital José Carrasco Arteaga, Cuenca.

2021 ◽  
Vol 13 (1) ◽  
pp. 83-89
Author(s):  
Fernanda Elizabeth Cali Chillogalli ◽  
Jessica Maribel Gutama Villa
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Peripheral Arterial Disease ◽  
Ankle Brachial Index ◽  
Arterial Disease ◽  
Disease Evolution ◽  
Number Of Patients ◽  
Peripheral Arterial

BACKGROUND: Peripheral arterial disease (PAD) is more common in patients with type 2 Diabetes Mellitus (DM2) than in the general population, making them a high-risk group for morbidity and mortality. The aim of this study was to determine the frequency of peripheral arterial disease, by measuring ankle-brachial index, and the frequency of its risks factors in patients with type 2 Diabetes Mellitus at Hospital José Carrasco Arteaga. METHODOS: descriptive, cross-sectional study, with a simply randomized sample of patients diagnosed with Type 2 Diabetes Mellitus, who attended the outpatient clinic of Hospital José Carrasco Arteaga, Cuenca - Ecuador, in 2017 ( 315 patients). An interview was applied to the patients, to collect data on sociodemographic characteristics and certain important medical history; ankle-brachial index was determined; complementary laboratory tests made six months prior to the study were evaluated. Finally, frequencies and percentages of each variable were described; we used IMB SPSS version 22 software. RESULTS: Of the total number of patients, the average age was 62.9 years, with a predominance of the female sex. The frequency of PAD in patients with DM2 was 35.30%. PAD was more frequent in: age group over 50 years (38.8%), male sex (43.9%), disease evolution time ≥ 5 years (35.5%), in smoking patients(38.4%), in patients with elevated glycosylated hemoglobin levels (HbA1c ≥7%)(40.6%),in patients with hypertriglyceridemia, in patients with elevated LDL and in men with low HDL values. CONCLUSION: we can conclude that the peripheral arterial disease frequency in patients with type 2 Diabetes Mellitus, at Hospital José Carrasco Arteaga, using the ankle-brachial index as a diagnostic method was 35.50%.

scholarly journals The relation of anatomical distribution of symptomatic peripheral arterial disease (PAD) with HbA1c level in patients with type 2 diabetes mellitus

2021 ◽  
Vol 12 ◽  
pp. 204201882110005
Author(s):  
Nawaf J. Shatnawi ◽  
Nabil A. Al-Zoubi ◽  
Hassan M. Hawamdeh ◽  
Yousef S. Khader ◽  
Mowafeq Heis ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Peripheral Arterial Disease ◽  
Hba1c Level ◽  
Arterial Disease ◽  
Anatomical Distribution ◽  
The Mean ◽  
Peripheral Arterial

Aims: Increased level of glycated hemoglobin (HbA1c) is associated with an increased prevalence of peripheral arterial disease (PAD). This study aimed to assess the relationship between the anatomical distribution of symptomatic PAD lesions in patients with type 2 diabetes and HbA1c levels at the time of PAD diagnosis. Patients and methods: A retrospective study was conducted at King Abdullah University Hospital during the period August 2011 to December 2015. Consecutive patients with type 2 diabetes presented with symptomatic PAD confirmed by computed tomography-angiography (CTA) were included in this study. CTA images were reviewed. Relevant information including demographic data, PAD symptoms, comorbidities, HbA1c level, lipid profile, C-reactive protein and the mean platelets volume were retrieved from medical records. Results: A total of 332 patients with type 2 diabetes (255 males and 77 females) were included in this study. The mean HbA1c at the time of PAD diagnosis was 8.68% (±2.06%). The prevalence of hemodynamic relevant atherosclerotic lesions of the superficial femoral artery, popliteal artery, leg vessels, femoro-popliteal, and crural segments was significantly higher in patients with HbA1c >7.5% compared with patients with HbA1c ⩽7.5%. Conclusion: The anatomical distribution of symptomatic PAD in patients with type 2 diabetes mellitus differed significantly according to HbA1c level at the time of PAD diagnosis.

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