Repair of bone defects using a new biomimetic construction fabricated by adipose-derived stem cells, collagen I, and porous beta-tricalcium phosphate scaffolds

2013 ◽  
Vol 238 (12) ◽  
pp. 1331-1343 ◽  
Author(s):  
Pei Yang ◽  
Xin Huang ◽  
Chunsheng Wang ◽  
Xiaoqian Dang ◽  
Kunzheng Wang
Keyword(s):  
Stem Cells ◽  
Tricalcium Phosphate ◽  
Bone Defects ◽  
Collagen I ◽  
Adipose Derived Stem Cells ◽  
Beta Tricalcium Phosphate

scholarly journals Cranioplasty with Adipose-Derived Stem Cells, Beta-Tricalcium Phosphate Granules and Supporting Mesh: Six-Year Clinical Follow-Up Results

2017 ◽  
Vol 6 (7) ◽  
pp. 1576-1582 ◽  
Author(s):  
Tuomo Thesleff ◽  
Kai Lehtimäki ◽  
Tero Niskakangas ◽  
Sanna Huovinen ◽  
Bettina Mannerström ◽  
...  
Keyword(s):  
Stem Cells ◽  
Tricalcium Phosphate ◽  
Adipose Derived Stem Cells ◽  
Beta Tricalcium Phosphate

Human Adipose-Derived Stem Cells on Rapid Prototyped Three-Dimensional Hydroxyapatite/Beta-Tricalcium Phosphate Scaffold

2016 ◽  
Vol 27 (3) ◽  
pp. 727-732 ◽  
Author(s):  
Elena Canciani ◽  
Claudia Dellavia ◽  
Lorena Maria Ferreira ◽  
Chiara Giannasi ◽  
Daniela Carmagnola ◽  
...  
Keyword(s):  
Stem Cells ◽  
Tricalcium Phosphate ◽  
Three Dimensional ◽  
Adipose Derived Stem Cells ◽  
Beta Tricalcium Phosphate

scholarly journals A Comparative Evaluation of the Mechanical Properties of Two Calcium Phosphate/Collagen Composite Materials and Their Osteogenic Effects on Adipose-Derived Stem Cells

2016 ◽  
Vol 2016 ◽  
pp. 1-12 ◽  
Author(s):  
Qing Li ◽  
Tong Wang ◽  
Gui-feng Zhang ◽  
Xin Yu ◽  
Jing Zhang ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Stem Cells ◽  
Composite Materials ◽  
Calcium Phosphate ◽  
Tricalcium Phosphate ◽  
Comparative Evaluation ◽  
Bone Defects ◽  
Adipose Derived Stem Cells ◽  
Composite Scaffolds

Adipose-derived stem cells (ADSCs) are ideal seed cells for use in bone tissue engineering and they have many advantages over other stem cells. In this study, two kinds of calcium phosphate/collagen composite scaffolds were prepared and their effects on the proliferation and osteogenic differentiation of ADSCs were investigated. The hydroxyapatite/β-tricalcium phosphate (HA/β-TCP) composite scaffolds (HTPSs), which have an additionalβ-tricalcium phosphate, resulted in better proliferation of ADSCs and showed osteogenesis-promoting effects. Therefore, such composite scaffolds, in combination with ADSCs or on their own, would be promising for use in bone regeneration and potential clinical therapy for bone defects.

Cranioplasty With Adipose-Derived Stem Cells and Biomaterial: A Novel Method for Cranial Reconstruction

Neurosurgery ◽  
2011 ◽  
Vol 68 (6) ◽  
pp. 1535-1540 ◽  
Author(s):  
Tuomo Thesleff ◽  
Kai Lehtimäki ◽  
Tero Niskakangas ◽  
Bettina Mannerström ◽  
Susanna Miettinen ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Stem Cells ◽  
Tricalcium Phosphate ◽  
Adipose Derived Stem Cells ◽  
Hounsfield Units ◽  
Beta Tricalcium Phosphate ◽  
Alloplastic Materials ◽  
Satisfactory Outcome ◽  
Calvarial Defects ◽  
Autologous Bone

Abstract BACKGROUND: There is no optimal method for reconstruction of large calvarial defects. Because of the limitations of autologous bone grafts and alloplastic materials, new methods for performing cranioplasties are needed. OBJECTIVE: To create autologous bone to repair cranial defects. METHODS: We performed a cranioplasty procedure with this new method in 4 patients who had large calvarial defects of different etiologies. We used autologous adipose-derived stem cells seeded in beta-tricalcium phosphate granules. For 2 patients, we used a bilaminate technique with resorbable mesh. RESULTS: During follow-up, there were no clinically relevant postoperative complications. The computed tomography scans revealed satisfactory outcome in ossification, and in the clinical examinations, the outcomes were good. The cranioplasty was measured in Hounsfield units from each computed tomography scan. The Hounsfield units increased gradually to equal the value of bone. CONCLUSION: The combination of scaffold material such as beta-tricalcium phosphate and autologous adipose-derived stem cells constitutes a promising model for reconstruction of human large cranial defects. The success of these clinical cases paves way for further studies and clinical applications to turn this method into a reliable treatment regimen.

scholarly journals Repair of bone defects using adipose-derived stem cells combined with alpha-tricalcium phosphate and gelatin sponge scaffolds in a rat model

2017 ◽  
Vol 25 (1) ◽  
pp. 10-19 ◽  
Author(s):  
Adriana CORSETTI ◽  
◽  
Claudia BAHUSCHEWSKYJ ◽  
Deise PONZONI ◽  
Renan LANGIE ◽  
...  
Keyword(s):  
Stem Cells ◽  
Rat Model ◽  
Tricalcium Phosphate ◽  
Bone Defects ◽  
Gelatin Sponge ◽  
Adipose Derived Stem Cells
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