Catastrophic Antiphospholipid Syndrome Following Lower Extremity Arterial Bypass Surgery: Case Report and Evidence Review

Catastrophic antiphospholipid syndrome (CAPS) is a rare life threatening presentation of antiphospholipid syndrome. Surgery has been proposed as one of the triggering factors for this life threatening entity. There are no detailed published reports in the current literature describing CAPS as a complication after surgery. We report a case of a 21 year old that developed CAPS postoperatively and discuss the multidisciplinary approach for diagnosis and management.

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Catastrophic antiphospholipid syndrome presenting with aortic barrage: case report and review of the literature

Lupus ◽

10.1177/09612033211004728 ◽

2021 ◽

Vol 30 (6) ◽

pp. 1005-1009

Author(s):

Luca Moroni ◽

Paolo Righini ◽

Giuseppe A Ramirez ◽

Nicola Farina ◽

Gaia Mancuso ◽

...

Keyword(s):

Risk Factors ◽

Case Report ◽

Antiphospholipid Syndrome ◽

Unusual Case ◽

Thromboembolic Events ◽

Review Of The Literature ◽

Catastrophic Antiphospholipid Syndrome ◽

Short Period ◽

Threatening Condition ◽

Life Threatening

Catastrophic antiphospholipid syndrome (CAPS) is a life-threatening condition characterized by multiple thromboembolic events occurring in a short period of time, frequently accompanied by significant systemic inflammation. Aortic involvement is rare in antiphospholipid syndrome and it had been never described in the context of its catastrophic variant. Here, we report an unusual case of aortic occlusion as a debut manifestation of CAPS and discuss its clinical features with an up-to-date review of the literature to identify risk factors and clues for clinical practice.

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Catastrophic antiphospholipid syndrome with bilateral adrenal hemorrhage: a case report

Endocrine Abstracts ◽

10.1530/endoabs.64.027 ◽

2019 ◽

Author(s):

De Marchi Lucrezia ◽

M K de Filette Jeroen ◽

Sol Bastiaan ◽

E Andreescu Corina ◽

Kunda Rastislav ◽

...

Keyword(s):

Case Report ◽

Antiphospholipid Syndrome ◽

Adrenal Hemorrhage ◽

Catastrophic Antiphospholipid Syndrome ◽

Bilateral Adrenal Hemorrhage

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210 Acute Renal Failure by Massive IVC Thromboses Treated With Mechanical Thrombectomy: A Case Report of Atypical Catastrophic Antiphospholipid Syndrome

American Journal of Kidney Diseases ◽

10.1053/j.ajkd.2021.02.215 ◽

2021 ◽

Vol 77 (4) ◽

pp. 633

Keyword(s):

Renal Failure ◽

Acute Renal Failure ◽

Case Report ◽

Antiphospholipid Syndrome ◽

Mechanical Thrombectomy ◽

Catastrophic Antiphospholipid Syndrome

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Arterial Thrombosis and Gangrene Secondary to Arachnidism

Vascular ◽

10.2310/6670.2009.00022 ◽

2009 ◽

Vol 17 (4) ◽

pp. 239-242

Author(s):

Jan M. Eckermann ◽

Theodore H. Teruya ◽

Christian Bianchi ◽

Ahmed M. Abou-Zamzam

Keyword(s):

Case Report ◽

Lower Extremity ◽

Vascular Disease ◽

Tissue Damage ◽

Arterial Thrombosis ◽

Progressive Necrosis ◽

Life Threatening ◽

History Of ◽

Spider Bites ◽

Spider Bite

Spider bites can cause local tissue damage as well as life-threatening complications. This is a case report of a female with no history of lower extremity vascular disease who presented with a spider bite on the dorsum of her foot. She developed progressive necrosis and eventually suffered limb loss despite attempts at revascularization.

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Antiphospholipid syndrome

Oxford Handbook of Rheumatology ◽

10.1093/med/9780198728252.003.0011 ◽

2018 ◽

pp. 375-388

Author(s):

Gavin Clunie ◽

Nick Wilkinson ◽

Elena Nikiphorou ◽

Deepak R. Jadon

Keyword(s):

Antiphospholipid Syndrome ◽

Clinical Presentation ◽

Therapeutic Targets ◽

Classification Criteria ◽

Catastrophic Antiphospholipid Syndrome ◽

Laboratory Features ◽

Life Threatening ◽

Novel Therapeutic

This chapter describes the clinical and laboratory classification criteria for antiphospholipid syndrome. It highlights the complexity and diagnostic challenges of antiphospholipid syndrome and discusses potential mimics of the disease that need to be excluded. Current therapeutic targets as well as novel therapeutic avenues are explored. The chapter finishes with a section on catastrophic antiphospholipid syndrome, which constitutes a rheumatological emergency. The clinical presentation, laboratory features, treatment, and outcomes of this life-threatening presentation of antiphospholipid syndrome are also discussed.

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