A Randomized Controlled Trial of Implant-retained Mandibular Overdentures

Evidence from randomized clinical trials of implant-retained overdentures is very limited at the present time. The aim of this study was to compare implant-retained mandibular overdentures and conventional complete dentures in a randomized controlled trial (RCT). Our a priori hypothesis was that implant-retained mandibular overdentures would be significantly better than conventional complete dentures. Edentulous patients (n = 118) were randomly allocated to either an Implant Group (n = 62) or a Denture Group (n = 56). Patients completed the Oral Health Impact Profile (OHIP) and a denture satisfaction scale pre-treatment and three months post-treatment. Upon completion of treatment, both groups reported improvement (p < 0.001, Wilcoxon Ranks Sum test) in oral-health-related quality of life and denture satisfaction. There were no significant post-treatment differences between the groups, but a treatment effect may be masked by application of “intention to treat” analysis. The OHIP change scores were significantly greater for patients receiving implants than for those who refused them.

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05 / The effect of an oral health optimized diet on periodontal and serological parameters. A randomized controlled trial.

10.26226/morressier.5ac383212afeeb00097a3f68 ◽

2018 ◽

Author(s):

Johan Woelber

Keyword(s):

Randomized Controlled Trial ◽

Oral Health ◽

Controlled Trial ◽

Randomized Controlled

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Faculty Opinions recommendation of Effect of dexmedetomidine versus lorazepam on outcome in patients with sepsis: an a priori-designed analysis of the MENDS randomized controlled trial.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.3614969.4741055 ◽

2010 ◽

Author(s):

John Kress

Keyword(s):

Randomized Controlled Trial ◽

Controlled Trial ◽

A Priori ◽

Randomized Controlled

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Comparing the effect of gain-frame and loss-frame SMS on the knowledge and practice of mothers with children less than 6 years of age in the field of children oral health: A randomized controlled trial

10.2196/preprints.9799 ◽

2018 ◽

Author(s):

Fatemeh Khademian ◽

Rita Rezaee ◽

Omid Pournik

Keyword(s):

Randomized Controlled Trial ◽

Oral Health ◽

Controlled Trial ◽

Randomized Controlled ◽

Knowledge And Practice ◽

Loss Frame ◽

Gain Frame

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Study protocol: a cluster randomized controlled trial to assess the effectiveness of a therapeutic educational program in oral health for persons with schizophrenia

International Journal of Mental Health Systems ◽

10.1186/s13033-016-0096-0 ◽

2016 ◽

Vol 10 (1) ◽

Cited By ~ 4

Author(s):

Frederic Denis ◽

Isabelle Millot ◽

Nicolas Abello ◽

Maud Carpentier ◽

Audrey Peteuil ◽

...

Keyword(s):

Randomized Controlled Trial ◽

Oral Health ◽

Study Protocol ◽

Educational Program ◽

Controlled Trial ◽

Cluster Randomized Controlled Trial ◽

Randomized Controlled ◽

Cluster Randomized ◽

Persons With Schizophrenia

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Acupuncture Versus Venlafaxine for the Management of Vasomotor Symptoms in Patients With Hormone Receptor–Positive Breast Cancer: A Randomized Controlled Trial

Journal of Clinical Oncology ◽

10.1200/jco.2009.23.5150 ◽

2010 ◽

Vol 28 (4) ◽

pp. 634-640 ◽

Cited By ~ 134

Author(s):

Eleanor M. Walker ◽

Alba I. Rodriguez ◽

Beth Kohn ◽

Ronald M. Ball ◽

Jan Pegg ◽

...

Keyword(s):

Breast Cancer ◽

Randomized Controlled Trial ◽

Adverse Effects ◽

Controlled Trial ◽

Hot Flashes ◽

Well Being ◽

Post Treatment ◽

Acupuncture Group ◽

Vasomotor Symptoms ◽

Randomized Controlled

Purpose Vasomotor symptoms are common adverse effects of antiestrogen hormone treatment in conventional breast cancer care. Hormone replacement therapy is contraindicated in patients with breast cancer. Venlafaxine (Effexor), the therapy of choice for these symptoms, has numerous adverse effects. Recent studies suggest acupuncture may be effective in reducing vasomotor symptoms in menopausal women. This randomized controlled trial tested whether acupuncture reduces vasomotor symptoms and produces fewer adverse effects than venlafaxine. Patients and Methods Fifty patients were randomly assigned to receive 12 weeks of acupuncture (n = 25) or venlafaxine (n = 25) treatment. Health outcomes were measured for up to 1 year post-treatment. Results Both groups exhibited significant decreases in hot flashes, depressive symptoms, and other quality-of-life symptoms, including significant improvements in mental health from pre- to post-treatment. These changes were similar in both groups, indicating that acupuncture was as effective as venlafaxine. By 2 weeks post-treatment, the venlafaxine group experienced significant increases in hot flashes, whereas hot flashes in the acupuncture group remained at low levels. The venlafaxine group experienced 18 incidences of adverse effects (eg, nausea, dry mouth, dizziness, anxiety), whereas the acupuncture group experienced no negative adverse effects. Acupuncture had the additional benefit of increased sex drive in some women, and most reported an improvement in their energy, clarity of thought, and sense of well-being. Conclusion Acupuncture appears to be equivalent to drug therapy in these patients. It is a safe, effective and durable treatment for vasomotor symptoms secondary to long-term antiestrogen hormone use in patients with breast cancer.

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Feasibility randomized controlled trial of a mind-body activity program for older adults with chronic pain and cognitive decline: The virtual “Active Brains” study

The Gerontologist ◽

10.1093/geront/gnab135 ◽

2021 ◽

Author(s):

James D Doorley ◽

Ryan A Mace ◽

Paula J Popok ◽

Victoria A Grunberg ◽

Anya Ragnhildstveit ◽

...

Keyword(s):

Older Adults ◽

Chronic Pain ◽

Randomized Controlled Trial ◽

Cognitive Decline ◽

Controlled Trial ◽

A Priori ◽

Exit Interviews ◽

Randomized Controlled ◽

Activity Program ◽

Body Activity

Abstract Background and Objectives Chronic pain (CP) and cognitive decline (CD) are highly co-morbid and debilitating among older adults. We iteratively developed Active Brains–Fitbit (AB-F), a group mind-body activity program aided by a Fitbit that is feasible and associated with improvements in physical, cognitive, and emotional functioning when delivered in person to older adults with CP and CD. We adapted our intervention and methodology for remote delivery to bypass barriers to participation. Here we report on a feasibility randomized controlled trial of the virtual AB-F versus a Health Enhancement Program (HEP) educational control followed by qualitative exit interviews. Research Design and Methods Older adults (age ≥ 60) with CP and CD (2 cohorts) completed eight weeks of AB-F (n = 8) or HEP (n = 11). Study procedures were fully remote via live video. Quantitative analyses explored feasibility and acceptability markers and within group improvements in outcomes. Qualitative analyses were primarily deductive using the Framework Method. Results AB-F met a-priori set feasibility benchmarks, similar to our in-person pilot. Participation in AB-F was associated with preliminary signals of improvement in multimodal physical function, emotional function (anxiety), cognitive function, pain intensity, and coping (e.g., pain self-efficacy, catastrophizing). Participation in HEP was associated with smaller or negligible improvements. Exit interviews confirmed feasibility and satisfaction with our completely remote interventions and methodology. Discussion and Implications Results provide evidence for the feasibility of our completely remote study, and for initial markers of improvement after AB-F. The results will inform a fully powered remote efficacy trial.

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