Quantitative EEG Effects of Topiramate

2003 ◽  
Vol 34 (2) ◽  
pp. 87-92 ◽  
Author(s):  
W. W. Wang ◽  
J. C. Li ◽  
X. Wu
Keyword(s):  
Slow Wave ◽  
Background Activity ◽  
Power Spectral Analysis ◽  
Quantitative Eeg ◽  
Healthy Adults ◽  
Total Power ◽  
Theta Band ◽  
Eeg Activity ◽  
Delta Band ◽  
Power Spectral

Objective: The study is to invesigate the effect of topiramate (TPM) on EEG by means of quantitative pharmacoelectroencephalography (QPEEG). Methods: One dose of TPM was administrated to epileptics and healthy adults. The EEG samples were obtained prior to and at regular intervals within the 24 hours following the administration of TPM. The EEG activity was processed with power spectral analysis. Results: The power of slow wave, alpha 1 bands and total power increased after the administration of TPM, the power or slow wave in both occipital areas, and the total power of all scalp areas also increased. The percent of power increased at the theta band and alpha 1 band (healthy adults) or delta band, theta band (patients). Conclusion: TPM can change the EEG background activity. These changes are different from other antiepileptic drugs.

scholarly journals Power spectral analysis of heart rate variability in Bangladeshi healthy population of different age

2014 ◽  
Vol 30 (1) ◽  
pp. 11-15
Author(s):  
Qazi Farzana Akhter ◽  
Qazi Shamima Akhter ◽  
Farhana Rahman ◽  
Sybyla Ferdousi ◽  
Susmita Sinha
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Spectral Analysis ◽  
Power Spectral Analysis ◽  
Autonomic Nerve ◽  
Total Power ◽  
Healthy Population ◽  
Cross Sectional ◽  
Power Spectral ◽  
Group A

Heart rate variability (HRV) has been considered as an indicator of autonomic nerve function status. We aimed to find out the reference values of heart rate variability by power spectral analysis in our healthy population of different age. This cross sectional study was conducted in the Department of Physiology, Dhaka Medical College, Dhaka from the period of July 2012 to June 2013. For this, 180 subjects were selected with the age ranging from 15-60 years. All the study subjects were divided into 3 different groups according to age (Group A: 15-30 years; Group B: 31-45 years; Group C: 46-60 years). Each group contained 60 subjects of which 30 were male and 30 were female. The subjects were selected from different areas of Dhaka city by personal contacts. Analysis of HRV parameters were done in Department of Physiology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka. For statistical analysis, one way ANOVA, unpaired Students t-test and Pearson’s correlation coefficient test were performed by using SPSS (version-17) as applicable. LF nu, LF power and LF/HF were significantly (p<0.001) higher in group C in comparison to those of group A and B. Again Total power, HF power, HF nu (p<0.001) were significantly higher in group A and B in comparison to that of group C. This study concludes that cardiac parasympathetic activity was decreased and sympathetic activity was increased with aging.DOI: http://dx.doi.org/10.3329/bjpp.v30i1.20788 Bangladesh J Physiol Pharmacol 2014; 30(1):11-15

Effects on sympathetic activity of 8-OHDPAT and clonidine in cat medullary lateral tegmental field

2001 ◽  
Vol 281 (2) ◽  
pp. H613-H622 ◽  
Author(s):  
Hakan S. Orer ◽  
Susan M. Barman ◽  
Gerard L. Gebber
Keyword(s):  
Sympathetic Activity ◽  
Power Spectral Analysis ◽  
Baroreceptor Reflex ◽  
Ventrolateral Medulla ◽  
Total Power ◽  
Power Spectral ◽  
Reflex Control ◽  
Selective Increase ◽  
Baroreceptor Reflex Control ◽  
Nerve Discharge

This study was designed to test the hypothesis that 8-hydroxy-2-(di- n-propylamino)tetralin (8-OHDPAT) and clonidine reduce sympathetic nerve discharge (SND) and mean arterial pressure (MAP), in part by actions in the medullary lateral tegmental field (LTF). We microinjected these drugs bilaterally into the LTF of baroreceptor-innervated and -denervated cats anesthetized with Dial-urethane. Neither drug altered SND (as quantified by using power spectral analysis) or MAP when injected into the LTF of baroreceptor-denervated cats. However, cardiac-related power in SND was significantly increased to 148 ± 12 (mean ± SE) and 149 ± 5% of control by microinjections of 8-OHDPAT ( n = 5) and clonidine ( n = 5), respectively, in baroreceptor-innervated cats whose MAP was kept constant; there was no change in 0- to 6-Hz power or total power. SND was significantly reduced by microinjection of these drugs into the rostral ventrolateral medulla of baroreceptor-innervated and -denervated cats. In conclusion, although 8-OHDPAT and clonidine did not reduce SND when injected into the LTF, they acted in this region to facilitate baroreceptor reflex control of SND, as evidenced by a selective increase in cardiac-related power.

scholarly journals Power Spectral Analysis of Heart Rate Variability in Heavy Workers

1970 ◽  
Vol 7 (1) ◽  
pp. 15-19
Author(s):  
S Mithun ◽  
N Begum ◽  
MM Hossain ◽  
S Ferdousi ◽  
R Tabassum
Keyword(s):  
Physical Activity ◽  
Heart Rate ◽  
Heart Rate Variability ◽  
Power Spectral Analysis ◽  
Regular Physical Activity ◽  
Total Power ◽  
Socioeconomic Condition ◽  
Power Spectral ◽  
The University ◽  
Sedentary Subjects

Introduction: Sedentary life style deteriorates Cardiac autonomic nervous activities (CANA). Regular physical activity may improve CANA. Objective: Heart rate variability (HRV) was analyzed by Power Spectral method in heavy workers to find out the influence of regular physical activity on CANA. Methods: This cross sectional study was carried out on 30 heavy workers aged 28-50 years (study group), at the Department of Physiology, Bangabandhu Sheikh Mujib Medical University (BSMMU) over a period of 1 year. Simultaneously 30 sedentary workers of high socioeconomic status (group C) were studied to observe the influence of socioeconomic condition on heart rate variability (HRV). For comparison thirty age, sex, body mass index (BMI) and socioeconomic condition matched apparently healthy sedentary subjects (control) were also studied. The study subjects were selected from rickshaw-pullers living in the slum area nearby the university and the controls from fourth class employee of the university. Group C were selected from the doctors serving in the university and some from personal contacts. Total power, low frequency (LF) power, high frequency (HF) power, LF nu (neutralized unit), HF nu and LF/HF ratio were assessed and analyzed by a Polygraph. For statistical analysis, one way analysis of variance (ANOVA), Independent-samples t-test and Pearson's correlation coefficient tests were done. Results: Total power, HF power and HF nu were significantly (p<0.001) higher and LF power, LF nu and LF/HF ratio were significantly (p<0.001) lower in heavy workers than those of sedentary subjects. Total power and HF nu showed positive correlations and LF nu and LF/HF ratio showed negative correlation with duration of works per day but all these correlations were statistically non-significant. Conclusion: Regular physical activity improves cardiac autonomic nerve function status with a cardiac parasympathetic predominance. Key words: Power spectral analysis (PSA); cardiac autonomic nervous activities (CANA); heavy workers; sedentary workers DOI: http://dx.doi.org/10.3329/jafmc.v7i1.8620 JAFMC Bangladesh. Vol 7, No 1 (June) 2011; 15-19

scholarly journals EEG Power Spectral Analysis of Abnormal Cortical Activations During REM/NREM Sleep in Obstructive Sleep Apnea

2021 ◽  
Vol 12 ◽  
Author(s):  
Shuling Liu ◽  
Jiucheng Shen ◽  
Yezhou Li ◽  
Jing Wang ◽  
Jianhua Wang ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Spectral Analysis ◽  
Power Spectral Analysis ◽  
Nrem Sleep ◽  
The Other ◽  
Frequency Bands ◽  
Delta Band ◽  
Power Spectral ◽  
Obstructive Sleep ◽  
Eeg Power

Objective: To characterize electroencephalogram (EEG) power in different frequency bands during rapid eye movement (REM) sleep and non-rapid eye movement (NREM) sleep in patients with obstructive sleep apnea (OSA).Methods: Retrospective data on 151 patients were collected and divided into three groups: primary snoring group (AHI &lt; 5/h), mild-moderate OSA group (6 ≤ AHI &lt; 30/h), and severe OSA group (AHI ≥ 30/h). EEG recordings in the frontal, central, and occipital regions were extracted from both REM and NREM sleep, to compute the normalized spectral power densities in the delta, theta, alpha, sigma, beta, and gamma frequency bands, using Fast Fourier Transform. Correlations between the computed EEG power and PSG parameters were analyzed.Results: In NREM sleep, elevated normalized power spectral density (PSD) in the delta band was observed in the severe OSA group compared to the other two groups. In contrast, the PSD of the other frequency bands showed a corresponding decrease in the severe OSA group. In REM sleep, similar changes were observed in the frontal region. Delta band PSD was positively correlated with Apnea Hypopnea Index (AHI) (r = 0.33), longest time of apnea, oxygen desaturation index (ODI) (r = 0.34), percent sleep time below 90% SaO2 (T90%) (r = 0.30), Arousal Index (ArI) (r = 0.29), and negatively correlated with N3%, minimum oxygen saturation (minSaO2).Conclusion: Our findings provide neurophysiological evidence for pathological cortical activation during REM/NREM sleep, which may be associated with the arousals and cognitive impairments in OSA. The technique of power spectral analysis could prove a potentially useful tool in complementing traditional PSG parameters in assessing disease burden to guide therapeutic decisions.

Slow Activity in Focal Epilepsy During Sleep and Wakefulness

2016 ◽  
Vol 48 (3) ◽  
pp. 200-208 ◽  
Author(s):  
Giovanni Pellegrino ◽  
Mario Tombini ◽  
Giuseppe Curcio ◽  
Chiara Campana ◽  
Giovanni Di Pino ◽  
...  
Keyword(s):  
Slow Wave ◽  
Focal Epilepsy ◽  
Wave Activity ◽  
Slow Wave Activity ◽  
Sleep Cycle ◽  
Delta Band ◽  
Power Spectral ◽  
Delta Sleep ◽  
Beta Frequency ◽  
Sleep Cycles

Introduction. We aimed to test differences between healthy subjects and patients with respect to slow wave activity during wakefulness and sleep. Methods. Fifteen patients affected by nonlesional focal epilepsy originating within temporal areas and fourteen matched controls underwent a 24-hour EEG recording. We studied the EEG power spectral density during wakefulness and sleep in delta (1-4 Hz), theta (5-7 Hz), alpha (8-11 Hz), sigma (12-15 Hz), and beta (16-20 Hz) bands. Results. During sleep, patients with focal epilepsy showed higher power from delta to beta frequency bands compared with controls. The effect was widespread for alpha band and above, while localized over the affected hemisphere for delta (sleep cycle 1, P = .006; sleep cycle 2, P = .008; sleep cycle 3, P = .017). The analysis of interhemispheric differences showed that the only frequency band stronger over the affected regions was the delta band during the first 2 sleep cycles (sleep cycle 1, P = .014; sleep cycle 2, P = .002). During wakefulness, patients showed higher delta/theta activity over the affected regions compared with controls. Conclusions. Patients with focal epilepsy showed a pattern of power increases characterized by a selective slow wave activity enhancement over the epileptic regions during daytime and sleep. This phenomenon was stronger and asymmetric during the first sleep cycles.

Prolonged Effects of Maternal Alcohol Ingestion on the Neonatal Electroencephalogram

PEDIATRICS ◽  
1984 ◽  
Vol 74 (3) ◽  
pp. 330-335
Author(s):  
S. Ioffe ◽  
R. Childiaeva ◽  
V. Chernick
Keyword(s):  
Preterm Infants ◽  
Brain Function ◽  
Matched Control ◽  
Newborn Infants ◽  
Power Spectral Analysis ◽  
Total Power ◽  
Control Group ◽  
Eeg Signals ◽  
Maternal Alcohol ◽  
Power Spectral

Newborn infants of mothers who drink heavily (&gt; 2 oz alcohol per day) during pregnancy have been shown to have hypersynchrony of the EEG. The possibility that hypersynchrony is related to acute alcohol withdrawal was tested. Eleven preterm infants of mothers who drank heavily ("alcoholic") were studued at a postnatal age of 4 to 6 weeks using power spectral analysis of EEG signals. This group was compared with a control group with similar racial and socioeconomic status. In addition, a group of ten "healthy" preterm infants was compared with a carefully matched control group. Total power of the EEG during quiet, indeterminate and rapid eye movement (REM) sleep was 162%, 183%, and 188%, respectively, in the infants whose mothers were alcoholic when compared with their control infants or with the healthy preterm infants and their control infants. It is concluded that ingestion of alcohol during pregnancy may result in potentially serious prolonged effects on brain function of the offspring, even in the absence of dysmorphology.

Power Spectral Analysis of EEG Activity During Sleep in Cigarette Smokers

CHEST Journal ◽  
2008 ◽  
Vol 133 (2) ◽  
pp. 427-432 ◽  
Author(s):  
Lin Zhang ◽  
Jonathan Samet ◽  
Brian Caffo ◽  
Isaac Bankman ◽  
Naresh M. Punjabi
Keyword(s):  
Spectral Analysis ◽  
Power Spectral Analysis ◽  
Cigarette Smokers ◽  
Eeg Activity ◽  
Power Spectral
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