The Association of Vitamin D3 With Early Anastomotic Leakage in Patients Undergoing Hemicolectomy Surgery

2021 ◽  
pp. 155335062110624
Author(s):  
Hojat Layeg ◽  
Vahide K. Meshki ◽  
Mohammad Y. Karami ◽  
Seyed Amin Moosavi ◽  
Ehsan Kafili ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Anastomotic Leakage ◽  
Vitamin D3 ◽  
Right Hemicolectomy ◽  
Cancer Surgery ◽  
Stapled Anastomosis ◽  
Right Colon ◽  
Right Colon Cancer ◽  
Colon Cancer Surgery ◽  
Sufficient Vitamin

Background Anastomotic leak (AL) is one of the most important postoperative complications after hemicolectomy with stapled anastomosis. This study aimed to evaluate the association of preoperative vitamin D3 with early anastomotic leakage after right colon cancer surgery with stapled anastomosis. Method In this prospective cohort study, 535 patients who underwent right colon cancer surgery (right hemicolectomy) with stapled anastomosis were enrolled. A subset of 315 patients was included in the study after meeting the inclusion criteria. Preoperative vitamin D level was measured and analyzed for association with early AL using univariable and multivariable logistic regression analyses. Result This study included 315 cases; among them, 18 (5.71%) patients developed early AL. Vitamin D3 was significantly higher among patients without early AL ( P < .001). Low vitamin D3 status was reported among 111 patients (35.2%) and 204 (64.8%) of patients did not have low vitamin D3 status (sufficient level = 30-100 ng/mL). Sufficient vitamin D3 levels before right colon cancer surgery with stapled anastomosis was associated inversely with early AL (crude OR = .89, 95% CI = .85-.94, P < .001 and adjusted OR = .89, 95% CI = .82-.98, P = .02). Conclusion The vitamin D3 level has a protective association with early AL. As a result, low vitamin D3 status may be a risk factor for early AL development, suggesting that it can be one of the predictors of early AL occurrence.

scholarly journals A case of portal venous gas after obstructive transverse colon cancer surgery

2019 ◽  
Vol 5 (1) ◽  
Author(s):  
Yuichiro Furutani ◽  
Chikashi Hiranuma ◽  
Masakazu Hattori ◽  
Kenji Doden ◽  
Yasuo Hashizume
Keyword(s):  
Colon Cancer ◽  
Conservative Treatment ◽  
Anastomotic Leakage ◽  
Transverse Colon ◽  
Cancer Surgery ◽  
Transverse Colon Cancer ◽  
Bowel Necrosis ◽  
Entire Area ◽  
Portal Venous Gas ◽  
Colon Cancer Surgery

Abstract Background Portal venous gas has traditionally been considered an inevitable harbinger of death due to its association with bowel necrosis. Recently, an increasing number of cases of portal venous gas have been reported in patients with various clinical conditions and without bowel necrosis. We herein report the case of a patient in whom portal venous gas developed after transverse colon cancer surgery. Case presentation A 69-year-old man who had transverse colon cancer underwent insertion of a transanal ileus tube for decompression. Transverse colon resection was performed on the 11th day after the insertion of the transanal ileus tube. The patient had a high fever on the 6th day after the operation. Computed tomography showed portal venous gas over the entire area of the liver and pneumatosis intestinalis in the wall of the ascending colon. There were no signs of anastomotic leakage or bowel necrosis, so we decided to use conservative therapy with fasting and antibiotics. The portal venous gas disappeared on the 19th day after the operation. The patient was discharged in good condition on the 29th day after the operation. Conclusions Conservative treatment for portal venous gas is reasonable for patients without signs of anastomotic leakage or bowel necrosis. However, it is important to carefully observe patients with portal venous gas during conservative treatment because portal venous gas may be life-threatening.

scholarly journals En bloc pancreaticoduodenectomy and right hemicolectomy to treat locally advanced right colon cancer: report of three cases

2010 ◽  
Vol 8 (1) ◽  
pp. 97-101 ◽  
Author(s):  
Sergio Renato Pais Costa ◽  
Sergio Henrique Couto Horta ◽  
Alexandre Cruz Henriques ◽  
Jaques Waisberg ◽  
Manlio Basílio Speranzini
Keyword(s):  
Colon Cancer ◽  
Locally Advanced ◽  
Pancreatic Head ◽  
Multivisceral Resection ◽  
Right Hemicolectomy ◽  
Right Colon ◽  
En Bloc ◽  
Term Survival ◽  
Proximal Duodenum ◽  
Right Colon Cancer

ABSTRACT Although colorectal tumors are fairly common surgical conditions, 5 to 12% of these tumors are locally advanced (T4 tumors) upon diagnosis. In this particular situation, the efficacy of en bloc multivisceral resection has been proven. When right-colon cancer invades the proximal duodenum or even the pancreatic head, a challenging dilemma arises due to complexity of the curative surgical procedure. Therefore, en bloc pancreaticoduodenectomy with right hemicolectomy should be performed to obtain free margins. The present study reports three cases of locally advanced right-colon cancer invading the proximal duodenum. All of these cases underwent successful en bloc pancreaticoduodenectomy plus right hemicolectomy, with no death occurrence. Long-term survival was observed in two cases (30 and 50 months). In the third case, the patient did not present any recurrence twelve months after surgical treatment. Multivisceral resection with en bloc pancreaticoduodenectomy should be considered for patients who present acceptable risk for major surgery and no distant dissemination. This approach seems justified since the length of postoperative survival is longer in radically ressected groups (R0) than in palliativelly resected groups (R1-2).

scholarly journals Symptomatic Anastomotic Leakage after Colon Cancer Surgery

2009 ◽  
Vol 62 (10) ◽  
pp. 807-811
Author(s):  
Masayuki Ohue ◽  
Shingo Noura ◽  
Tatsushi Shingai ◽  
Shingo Kano ◽  
Isao Miyashiro
Keyword(s):  
Colon Cancer ◽  
Anastomotic Leakage ◽  
Cancer Surgery ◽  
Colon Cancer Surgery

Outcomes after combined right hemicolectomy and pancreaticoduodenectomy for locally advanced right-sided colon cancer: a case series

2020 ◽  
Keyword(s):  
Colon Cancer ◽  
Locally Advanced ◽  
Case Series ◽  
Disease Free Survival ◽  
Right Hemicolectomy ◽  
R0 Resection ◽  
Right Colon ◽  
En Bloc ◽  
Mortality And Morbidity ◽  
Right Colon Cancer

Background: Although right colon cancers mostly grow intraluminally, they may rarely invade neighboring organs without distant organ metastasis. En bloc resection is required for R0 resection in pancreas and duodenum-invasive right colon tumors. Despite the high mortality and morbidity rates, the en bloc right hemicolectomy and pancreaticoduodenectomy (RHPD) procedure can be safely performed in centers experienced in colorectal and hepatobiliary surgery. Objective: In this study, we aimed to share the results of our patients who underwent en bloc pancreaticoduodenectomy in addition to right hemicolectomy for cases with locally advanced right colon cancer. Materials and Methods: Patients who were operated on the right colon cancer between January 2010 and March 2018 were retrospectively screened. Patients who underwent RHPD due to locally advanced colon cancer invading the duodenum and pancreas were included in this study. RHPD was performed in cases where radical resection was deemed appropriate, and R0 resection could be performed. Demographic information, intraoperative and postoperative findings, and long-term follow-up data of the patients were recorded. Results: Six cases underwent RHPD. All of the cases were male, and the mean age was 67 ± 6. Proximal PD was performed in five cases, and total PD was performed in one case. SMV reconstruction was performed in one case with an SMV invasion. One case died due to pneumonia and anastomotic leak in the postoperative period. The other five patients had a mean disease-free survival of 29.2 ± 14.7 months. The 1 and 2-year survival rate was 66.6% and 66.6%, respectively. Conclusion: RHPD is a surgical operation that can be performed safely in experienced centers with acceptable mortality and morbidity rates in cases suitable for R0 resection.

Right hemicolectomy and multivisceral resection of right colon cancer: A report of 21 cases

2015 ◽  
Vol 35 (2) ◽  
pp. 255-258 ◽  
Author(s):  
Yu-zhou Zhao ◽  
Guang-sen Han ◽  
Chao-min Lu ◽  
Ying-kun Ren ◽  
Jian Li ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Multivisceral Resection ◽  
Right Hemicolectomy ◽  
Right Colon ◽  
Right Colon Cancer

scholarly journals Laparoscopic versus Open Transverse-Incision Approach for Right Hemicolectomy: A Systematic Review and Meta-Analysis

Medicina ◽  
2021 ◽  
Vol 57 (1) ◽  
pp. 80
Author(s):  
Claudio F. Feo ◽  
Panagiotis Paliogiannis ◽  
Alessandro Fancellu ◽  
Angelo Zinellu ◽  
Giorgio C. Ginesu ◽  
...  
Keyword(s):  
Systematic Review ◽  
Colon Cancer ◽  
Hospital Stay ◽  
Open Surgery ◽  
Operative Time ◽  
Meta Analysis ◽  
Right Hemicolectomy ◽  
Transverse Incision ◽  
Right Colon ◽  
Right Colon Cancer

Background and Objectives: There is general agreement on the benefits of laparoscopy for treatment of rectal and left colon cancers, whereas findings regarding the comparison of laparoscopic and open right colonic resections are discordant. The aim of this systematic review and meta-analysis was to assess the outcomes and advantages of laparoscopic versus transverse-incision open surgery for management of right colon cancer. Materials and Methods: A systematic review was performed according to the Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) guidelines. Comparative studies evaluating the results of laparoscopic and transverse-incision open right hemicolectomies were analyzed. The measured outcomes were mean operative time, time to feeding, duration of hospital stay, and number of lymph nodes harvested. Results: A total of 5 studies including 318 patients met the inclusion criteria. Meta-analysis revealed no differences in time to resume oral feeding, hospital stay, and number of lymph nodes harvested in between groups, but mean length of surgery was significantly longer in the laparoscopic group. Conclusion: These data confirm that the preferred approach to right hemicolectomy is yet unclear. Laparoscopy has a longer operative time than transverse-incision open surgery, and no significant short-term benefits were observed for the studied parameters. Well-designed randomized control trials (RCTs) might help to identify the differences between these two techniques for the surgical treatment of right colon cancer.

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