scholarly journals Gamma glutamyl transpeptidase as a prognostic biomarker in hepatocellular cancer patients especially with >5 cm tumors, treated by liver transplantation

2020 ◽  
Vol 35 (2) ◽  
pp. 91-95 ◽  
Author(s):  
Volkan Ince ◽  
Brian I. Carr ◽  
Harika Gozukara Bag ◽  
Cemalettin Koc ◽  
Sertac Usta ◽  
...  
Keyword(s):  
Prognostic Biomarker ◽  
Elevated Serum ◽  
Hepatocellular Cancer ◽  
Clear Correlation ◽  
Tumor Diameter ◽  
Gamma Glutamyl Transpeptidase ◽  
Gamma Glutamyl ◽  
Cell Lineages ◽  
Large Size ◽  
Glutamyl Transpeptidase

Background Serum AFP levels are typically elevated in less than 50% of hepatocellular cancer (HCC) patients. Gamma-glutamyl transpeptidase (GGT) levels have been suggested to be a potentially useful HCC biomarker. Aims To assess in a cohort of prospectively evaluated HCC patients who underwent liver transplant and whose survival was known; the occurrence, prognosis, and clinical characteristics of patients with elevated serum GGT levels. Results Serum GGT levels were found to be elevated in a higher proportion in patients with either small or large HCC than alpha-fetoprotein (AFP) levels, and were significantly related to prognosis in patients with large size HCCs. There was no clear correlation between GGT and AFP levels, likely reflecting different HCC characteristics or HCC cell lineages associated with these two markers. Furthermore, elevated GGT was found in 24% of low-AFP patients with small tumors and 46% with large tumors. Elevated GGT levels were also significantly associated with microvascular invasion and tumor diameter. Conclusions Elevated serum GGT levels were associated with HCC size and worse survival, and were unrelated to AFP levels. GGT may be a useful prognostic tumor marker, especially for low-AFP HCC patients.

scholarly journals Early elevated serum gamma glutamyl transpeptidase after liver transplantation is associated with better survival

F1000Research ◽  
2014 ◽  
Vol 3 ◽  
pp. 85 ◽  
Author(s):  
Edris M Alkozai ◽  
Ton Lisman ◽  
Robert J Porte ◽  
Maarten W Nijsten
Keyword(s):  
Liver Transplantation ◽  
Aspartate Aminotransferase ◽  
Alanine Aminotransferase ◽  
Total Bilirubin ◽  
Elevated Serum ◽  
Glutathione Metabolism ◽  
Gamma Glutamyl Transpeptidase ◽  
Gamma Glutamyl ◽  
Increased Risk ◽  
Glutamyl Transpeptidase

Background: Gamma glutamyl transpeptidase (GGT) is a membrane bound enzyme that plays a key role in the synthesis of the antioxidant glutathione. Epidemiological studies have linked high GGT with an increased risk of morbidity and cardiovascular mortality. In contrast, GGT is usually elevated in liver transplant recipients that experience good outcomes.Aims: To study if and how GGT is correlated with mortality following liver transplantation.Methods: We analyzed the prognostic relevance of serum GGT levels during the early and late postoperative period after liver transplantation in 522 consecutive adults. We also studied alanine aminotransferase, aspartate aminotransferase, and total bilirubin levels.Results: Early after transplantation, the peak median (interquartile range) GGT levels were significantly higher in patients who survived more than 90 days compared to non-survivors: 293 (178-464) vs. 172 (84-239) U/l, p<0.0001. In contrast, late after transplantation, GGT levels were significantly lower in patients who survived more than 5 years than those who did not (p<0.01). The pattern of GGT levels also differed from those of alanine aminotransferase, aspartate aminotransferase, and total bilirubin early after transplantation, while these patterns were congruent late after transplantation. Kaplan-Meier survival analysis showed that early after transplantation the higher the GGT levels, the better the 90-day survival (p<0.001). In contrast, late after transplantation, higher GGT levels were associated with a lower 5-year survival (p<0.001).Conclusions:  These paradoxical findings may be explained by the time-dependent role of GGT in glutathione metabolism. Immediate postoperative elevation of GGT may indicate a physiological systemic response while chronic elevation reflects a pathological response.

scholarly journals Elevated Serum Gamma-glutamyl Transpeptidase Levels and Fatty Liver Strongly Predict the Presence of Carotid Plaque

2015 ◽  
Vol 22 (10) ◽  
pp. 1051-1060 ◽  
Author(s):  
Nobuyuki Toshikuni ◽  
Takayoshi Asaji ◽  
Yumiko Nakanishi ◽  
Shin-ya Nagasawa ◽  
Hiroaki Uenishi ◽  
...  
Keyword(s):  
Fatty Liver ◽  
Carotid Plaque ◽  
Elevated Serum ◽  
Gamma Glutamyl Transpeptidase ◽  
Gamma Glutamyl ◽  
Glutamyl Transpeptidase

Ultrasonographic hepatic steatosis increases prediction of mortality risk from elevated serum gamma-glutamyl transpeptidase levels

Hepatology ◽  
2009 ◽  
Vol 50 (5) ◽  
pp. 1403-1411 ◽  
Author(s):  
Robin Haring ◽  
Henri Wallaschofski ◽  
Matthias Nauck ◽  
Marcus Dörr ◽  
Sebastian E. Baumeister ◽  
...  
Keyword(s):  
Hepatic Steatosis ◽  
Mortality Risk ◽  
Elevated Serum ◽  
Gamma Glutamyl Transpeptidase ◽  
Gamma Glutamyl ◽  
Prediction Of Mortality ◽  
Glutamyl Transpeptidase

Relationship Between Gamma-glutamyl Transpeptidase Activity and Inflammatory Response in Lichen Planus

2018 ◽  
Vol 69 (3) ◽  
pp. 739-743 ◽  
Author(s):  
Madalina Irina Mitran ◽  
Ilinca Nicolae ◽  
Corina Daniela Ene ◽  
Cristina Iulia Mitran ◽  
Clara Matei ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Lichen Planus ◽  
Inflammatory Process ◽  
Molecular Mechanisms ◽  
Functional Adaptation ◽  
Physical Factors ◽  
Inflammatory Disorder ◽  
Gamma Glutamyl Transpeptidase ◽  
Gamma Glutamyl ◽  
Glutamyl Transpeptidase

Chemicals used in the manufacture of synthetic fibers have been associated with undesirable side effects such as itching or skin lesions and it seems that they are involved in the induction of pathological processes such as oxidative stress and inflammation. Lichen planus (LP) can be regarded as an inflammatory disorder, chemical and physical factors playing an important role in the perpetuation of the inflammatory process. Gamma-glutamyl transpeptidase (GGT) plays an important role in the preservation of skin architecture and modulation of skin inflammation. In this study, we found that GGT activity is increased in LP patients with mild inflammation, whilst GGT is inactivated under conditions of severe inflammation. Therefore, GGT is involved in the inflammatory process, but there is no a positive correlation between its activity and the intensity of the inflammatory response. This functional adaptation of the enzyme may be due to down-regulation of its synthesis under free radical overload conditions. Understanding the molecular mechanisms involved in the modulation of intracellular redox homeostasis is an important step in the pharmacological management of patients with LP.

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