AKT answer relating to macrocytic anaemia

Introduction: Severe anaemia is a leading cause of paediatric morbidity, hospitalization, and mortality and it is very important co morbidity in children with severe acute malnutrition. Severe Acute Malnutrition (SAM) with anaemia has been shown to have 2.62 times higher mortality as compared to SAM with no anaemia. So this study was done to evaluate this co-morbidity further. The aim of present study was to determine the prevalence and type of anaemia and to evaluate the possible aetiologies of anaemia in severe acute malnourished (SAM) children.Material and Methods: In tertiary care hospital a cross sectional study was conducted over a period of 8 month with 100 cases of SAM children and 101 cases of normal children. In both cases disorders of primary haematological problem were excluded. Auto analysers were used to measure blood counts. Blood smear was analysed by pathology consultant of institute and recorded for all patients with anaemia. Grade of anaemia and morphologic type of anaemia was analysed. Data were entered in Excel spreadsheets and analysed using SPSS 20.0.Results: Patient with SAM 42% had moderate anaemia and 19% had severe anaemia in contrast 41.6% and 16.8% in NON SAM child respectively. Predominant morphologic type in SAM patient was macrocytic anaemia (33%), while in controls microcytic anaemia (40.6%) was more prevalent.Conclusion: There was a high prevalence of anaemia in SAM children. Major morphologic type in SAM children was macrocytic anaemia which may indirectly show vitamin B12 or folic acid deficiency in these children.

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Nutritional Macrocytic Anaemia in Temperate Zones

BMJ ◽

10.1136/bmj.1.4615.1079 ◽

1949 ◽

Vol 1 (4615) ◽

pp. 1079-1081 ◽

Cited By ~ 1

Author(s):

J. Rubie ◽

C. D. Calnan

Keyword(s):

Macrocytic Anaemia

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Intestinal Macrocytic Anaemia

BMJ ◽

10.1136/bmj.1.4748.13 ◽

1952 ◽

Vol 1 (4748) ◽

pp. 13-17 ◽

Cited By ~ 31

Author(s):

G. M. Watson ◽

L. J. Witts

Keyword(s):

Macrocytic Anaemia

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Anti-pernicious-anaemia Factor for Tropical Macrocytic Anaemia

BMJ ◽

10.1136/bmj.2.4586.934 ◽

1948 ◽

Vol 2 (4586) ◽

pp. 934-935 ◽

Cited By ~ 4

Author(s):

J. C. Patel

Keyword(s):

Pernicious Anaemia ◽

Macrocytic Anaemia

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The VEXAS Syndrome: Uncontrolled Inflammation and Macrocytic Anaemia in a 77-Year-Old Male Patient

European Journal of Case Reports in Internal Medicine ◽

10.12890/2021_002484 ◽

2021 ◽

Author(s):

Andreas Himmelmann ◽

Rolf Brücker

Keyword(s):

Relapsing Polychondritis ◽

Recurrent Fever ◽

Sweet’S Syndrome ◽

Macrocytic Anaemia ◽

Disease Modifying Drugs ◽

Sweet's Syndrome ◽

Inflammatory Processes ◽

High Doses ◽

Almost All ◽

Autoinflammatory Condition

The VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome is a recently described X-linked autoinflammatory condition caused by a somatic mutation of the UBA1 gene and characterized by an evolving phenotype. This includes inflammatory processes such as recurrent fever, Sweet’s syndrome of the skin, pulmonary fibrosis, relapsing polychondritis and venous thromboembolism. An important feature, present in almost all cases, is the development of a macrocytic anaemia with vacuolization of myeloid and erythroid precursors. Usually, these patients require high doses of steroids to control symptoms and respond poorly to disease-modifying drugs. We describe a new case of the VEXAS syndrome presenting with Sweet’s syndrome which has now been followed for 6 years.

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