Rodent Models to Analyze the Glioma Microenvironment

Animal models are still indispensable for understanding the basic principles of glioma development and invasion. Preclinical approaches aim to analyze the treatment efficacy of new drugs before translation into clinical trials is possible. Various animal disease models are available, but not every approach is useful for addressing specific questions. In recent years, it has become increasingly evident that the tumor microenvironment plays a key role in the nature of glioma. In addition to providing an overview, this review evaluates available rodent models in terms of usability for research on the glioma microenvironment.

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Challenges and advances in clinical applications of mesenchymal stromal cells

Journal of Hematology & Oncology ◽

10.1186/s13045-021-01037-x ◽

2021 ◽

Vol 14 (1) ◽

Author(s):

Tian Zhou ◽

Zenan Yuan ◽

Jianyu Weng ◽

Duanqing Pei ◽

Xin Du ◽

...

Keyword(s):

Stem Cells ◽

Clinical Trials ◽

Mesenchymal Stem Cells ◽

Mesenchymal Stromal Cells ◽

Stromal Cells ◽

Therapeutic Potential ◽

Clinical Applications ◽

Disease Models ◽

Animal Disease ◽

Animal Disease Models

AbstractMesenchymal stromal cells (MSCs), also known as mesenchymal stem cells, have been intensely investigated for clinical applications within the last decades. However, the majority of registered clinical trials applying MSC therapy for diverse human diseases have fallen short of expectations, despite the encouraging pre-clinical outcomes in varied animal disease models. This can be attributable to inconsistent criteria for MSCs identity across studies and their inherited heterogeneity. Nowadays, with the emergence of advanced biological techniques and substantial improvements in bio-engineered materials, strategies have been developed to overcome clinical challenges in MSC application. Here in this review, we will discuss the major challenges of MSC therapies in clinical application, the factors impacting the diversity of MSCs, the potential approaches that modify MSC products with the highest therapeutic potential, and finally the usage of MSCs for COVID-19 pandemic disease.

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Neuro-immune interactions of neural stem cell transplants: From animal disease models to human trials

Experimental Neurology ◽

10.1016/j.expneurol.2013.03.009 ◽

2014 ◽

Vol 260 ◽

pp. 19-32 ◽

Cited By ~ 47

Author(s):

Elena Giusto ◽

Matteo Donegà ◽

Chiara Cossetti ◽

Stefano Pluchino

Keyword(s):

Stem Cell ◽

Neural Stem Cell ◽

Disease Models ◽

Animal Disease ◽

Human Trials ◽

Animal Disease Models ◽

Cell Transplants ◽

Stem Cell Transplants

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Aldosterone synthase inhibition: cardiorenal protection in animal disease models and translation of hormonal effects to human subjects

Journal of Translational Medicine ◽

10.1186/s12967-014-0340-9 ◽

2014 ◽

Vol 12 (1) ◽

Cited By ~ 20

Author(s):

Joël Ménard ◽

Dean F Rigel ◽

Catherine Watson ◽

Arco Y Jeng ◽

Fumin Fu ◽

...

Keyword(s):

Human Subjects ◽

Disease Models ◽

Animal Disease ◽

Aldosterone Synthase ◽

Hormonal Effects ◽

Animal Disease Models

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Murine and human cathepsin B exhibit similar properties: possible implications for drug discovery

Biological Chemistry ◽

10.1515/bc.2009.021 ◽

2009 ◽

Vol 390 (2) ◽

pp. 175-179 ◽

Cited By ~ 5

Author(s):

Dejan Caglič ◽

Gregor Kosec ◽

Lea Bojič ◽

Thomas Reinheckel ◽

Vito Turk ◽

...

Keyword(s):

Mouse Models ◽

Cathepsin B ◽

Drug Targets ◽

Biochemical Properties ◽

Disease Models ◽

Preclinical Studies ◽

Animal Disease ◽

Transgenic Mouse Models ◽

Animal Disease Models ◽

Human Cathepsin

Abstract Validation of drug targets and subsequent preclinical studies are usually carried out on animal disease models, with mouse being the most commonly used. However, results from mouse models cannot always be directly related to human disease. Major discrepancies between the properties of murine and human variants were observed during the evaluation of compounds targeting cathepsins S and K. It is important, therefore, to know whether similar differences exist between murine and human cathepsin B. Thus, both enzymes were expressed and biochemically characterized. The enzymes exhibited similar biochemical properties, indicating that cathepsin B transgenic mouse models could be useful for studying its role in human pathologies.

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