scholarly journals Novel Bisabolane Sesquiterpenes from the Marine-derived Fungus Verticillium tenerum

2010 ◽  
Vol 5 (4) ◽  
pp. 1934578X1000500 ◽  
Author(s):  
Celso Almeida ◽  
Somaia Elsaedi ◽  
Stefan Kehraus ◽  
Gabriele M. König
Keyword(s):  
Absolute Configuration ◽  
Cd Spectroscopy ◽  
Mass Spectrometric ◽  
Planar Structures ◽  
The Absolute ◽  
New Compounds ◽  
Mass Spectrometric Techniques

Chemical investigations of the marine-derived fungus Verticillium tenerum yielded two new hydroxylated bisabolane-type sesquiterpenes verticinol A (1) and B (2). The planar structures of the new compounds were elucidated by employing spectroscopic (NMR, UV, and IR) and mass spectrometric techniques. The absolute configuration of the cyclohexenyl moiety was deduced by a combination of CD spectroscopy and NOESY measurements.

scholarly journals New Diterpenoids and Isocoumarin Derivatives from the Mangrove-Derived Fungus Hypoxylon sp.

Marine Drugs ◽  
2021 ◽  
Vol 19 (7) ◽  
pp. 362
Author(s):  
Bolin Hou ◽  
Sushi Liu ◽  
Ruiyun Huo ◽  
Yueqian Li ◽  
Jinwei Ren ◽  
...  
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Crude Extract ◽  
Mass Spectrometric ◽  
Spectrometric Analysis ◽  
Ic50 Values ◽  
Inhibitory Activities ◽  
The Absolute ◽  
Dpph Scavenging ◽  
New Compounds

Two new diterpenoids, hypoxyterpoids A (1) and B (2), and four new isocoumarin derivatives, hypoxymarins A–D (4–7), together, with seven known metabolites (3 and 8–13) were obtained from the crude extract of the mangrove-derived fungus Hypoxylon sp. The structures of the new compounds were elucidated on the basis of 1- and 2-dimensional (1D/2D) nuclear magnetic resonance (NMR) spectroscopic and mass spectrometric analysis. The absolute configurations of compounds 1, 2, 4, 5, and 7 were determined by comparison of experimental and calculated electronic circular dichroism (ECD) spectra, and the absolute configurations of C-4′ in 6 and C-9 in 7 were determined by [Rh2(OCOCF3)4]-induced ECD spectra. Compound 1 showed moderate α-glucosidase inhibitory activities with IC50 values of 741.5 ± 2.83 μM. Compounds 6 and 11 exhibited DPPH scavenging activities with IC50 values of 15.36 ± 0.24 and 3.69 ± 0.07 μM, respectively.

Alkaloids of Rauvolfia salicifolia GRISEB species

1982 ◽  
Vol 47 (11) ◽  
pp. 2912-2921 ◽  
Author(s):  
Patricia Sierra ◽  
Ladislav Novotný ◽  
Zdeněk Samek ◽  
Miloš Buděšínský ◽  
Ladislav Dolejš ◽  
...  
Keyword(s):  
Absolute Configuration ◽  
Cd Spectroscopy ◽  
X Ray Diffraction ◽  
X Ray ◽  
The Absolute

From the endemic Cuban species Rauvolfia salicifolia GRISEB nine alkaloids were isolated of which the following seven had been already described: (+)-ajmalidine (I), (-)-reserpiline (II), (-)-isoreserpiline (III), (-)-isocarapanaubine (IV), (-)-ajmalicine (V), (+)-vellosimine (VI), and (+)-yohimbine (VII). The structure of (-)-raucubaine (VIII) had been previously determined by X-ray diffraction and the structure of the alkaloid (-)-raucubainine (IX) was suggested on the basis of its conversion to (-)-raucubaine (VIII). The absolute configuration of (-)-raucubaine and (-)-raucubainine was elucidated by CD spectroscopy.

Synthesis and Determination of the Absolute Configuration of Fugomycin and Desoxyfugomycin: CD Spectroscopy and Fungicidal Activity of Butenolides

2004 ◽  
Vol 10 (18) ◽  
pp. 4584-4593 ◽  
Author(s):  
Manfred Braun ◽  
Andreas Hohmann ◽  
Jaykumar Rahematpura ◽  
Corinna Bühne ◽  
Stefan Grimme
Keyword(s):  
Absolute Configuration ◽  
Fungicidal Activity ◽  
Cd Spectroscopy ◽  
The Absolute

Sesquiterpenic lactones of Inula aschersoniana JANKA var. aschersoniana species

1990 ◽  
Vol 55 (6) ◽  
pp. 1562-1567 ◽  
Author(s):  
Ełżbieta Błoszyk ◽  
Miloš Buděšínský ◽  
Włodzimierz M. Daniewski ◽  
Eva Pešková ◽  
Bohdan Drożdż ◽  
...  
Keyword(s):  
Absolute Configuration ◽  
Cd Spectroscopy ◽  
H Nmr ◽  
Aerial Parts ◽  
The Absolute

Aerial parts of species Inula aschersoniana JANKA var. aschersoniana have been shown to contain parthenolide (I), costunolide diepoxide (III) and the hitherto undescribed inusoniolide (IV) whose structure, including the absolute configuration, was determined using 1H NMR and CD spectroscopy.

Boron-Based Diastereomerism and Enantiomerism in Imine Complexes - Determination of the Absolute Configuration at Boron by CD Spectroscopy

2008 ◽  
Vol 2008 (31) ◽  
pp. 5221-5225 ◽  
Author(s):  
Manfred Braun ◽  
Sebastian Schlecht ◽  
Marco Engelmann ◽  
Walter Frank ◽  
Stefan Grimme
Keyword(s):  
Absolute Configuration ◽  
Cd Spectroscopy ◽  
The Absolute

scholarly journals Penigrisacids A–D, Four New Sesquiterpenes from the Deep-Sea-Derived Penicillium griseofulvum

Marine Drugs ◽  
2019 ◽  
Vol 17 (9) ◽  
pp. 507 ◽  
Author(s):  
Cui-Ping Xing ◽  
Chun-Lan Xie ◽  
Jin-Mei Xia ◽  
Qing-Mei Liu ◽  
Wei-Xiang Lin ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Deep Sea ◽  
Optical Rotation ◽  
Electronic Circular Dichroism ◽  
Planar Structures ◽  
Extensive Analysis ◽  
Ic50 Value ◽  
Penicillium Griseofulvum ◽  
The Absolute ◽  
New Compounds

Four new (penigrisacids A–D, 1–4) and one known (5) carotane sesquiterpenoids were isolated from the deep-sea-derived fungus Penicillium griseofulvum, along with four known compounds (6–9). The planar structures and relative configurations of the new compounds were determined by extensive analysis of the NMR and HRESIMS data. The absolute configurations were established by comparison of the experimental and calculated ECD (electronic circular dichroism) spectra or OR (optical rotation) value. Compound 9 exhibited potent anti-food allergic activity with IC50 value of 28.7 μM, while 4 showed weak cytotoxicity against ECA-109 tumor cells (IC50 = 28.7 μM).

The isolation, identification, and bioassay of the antifungal metabolites produced by Monocillium nordinii

1980 ◽  
Vol 26 (7) ◽  
pp. 766-773 ◽  
Author(s):  
William A. Ayer ◽  
Sing Ping Lee ◽  
Akihiko Tsuneda ◽  
Yasuyuki Hiratsuka
Keyword(s):  
Absolute Configuration ◽  
Liquid Culture ◽  
Dutch Elm Disease ◽  
Antifungal Metabolites ◽  
The Absolute ◽  
New Compounds

The metabolites produced when Monocillium nordinii (Bourchier) W. Gams, a destructive mycoparasite of pine stem rusts, is grown in liquid culture have been separated and identified. The metabolites include the known compound monorden (1) and five new substances, monocillin I (2), monocillin II (4), monocillin III (3), monocillin IV (5), and monocillin V (6). Structural assignments and chemical correlations of the five new compounds are reported and the absolute configuration of monorden is assigned. The antifungal spectra of the three major metabolites are reported. Monorden and monocillin I show pronounced activity against a wide variety of fungi, including Ceratocystis ulmi, the cause of Dutch elm disease. Extraction of the mycelium yielded averufin (13), along with a pigment C18H12O6, as yet unidentified.

ChemInform Abstract: The Determination of the Absolute Configuration of a Chiral Molecular Tweezer Using CD Spectroscopy.

ChemInform ◽  
2010 ◽  
Vol 29 (9) ◽  
pp. no-no
Author(s):  
J. FLEISCHHAUER ◽  
M. HARMATA ◽  
M. KAHRAMAN ◽  
A. KOSLOWSKI ◽  
C. J. WELCH
Keyword(s):  
Absolute Configuration ◽  
Cd Spectroscopy ◽  
The Absolute ◽  
Molecular Tweezer
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