scholarly journals New Diterpenoids and Isocoumarin Derivatives from the Mangrove-Derived Fungus Hypoxylon sp.

Marine Drugs ◽  
2021 ◽  
Vol 19 (7) ◽  
pp. 362
Author(s):  
Bolin Hou ◽  
Sushi Liu ◽  
Ruiyun Huo ◽  
Yueqian Li ◽  
Jinwei Ren ◽  
...  
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Crude Extract ◽  
Mass Spectrometric ◽  
Spectrometric Analysis ◽  
Ic50 Values ◽  
Inhibitory Activities ◽  
The Absolute ◽  
Dpph Scavenging ◽  
New Compounds

Two new diterpenoids, hypoxyterpoids A (1) and B (2), and four new isocoumarin derivatives, hypoxymarins A–D (4–7), together, with seven known metabolites (3 and 8–13) were obtained from the crude extract of the mangrove-derived fungus Hypoxylon sp. The structures of the new compounds were elucidated on the basis of 1- and 2-dimensional (1D/2D) nuclear magnetic resonance (NMR) spectroscopic and mass spectrometric analysis. The absolute configurations of compounds 1, 2, 4, 5, and 7 were determined by comparison of experimental and calculated electronic circular dichroism (ECD) spectra, and the absolute configurations of C-4′ in 6 and C-9 in 7 were determined by [Rh2(OCOCF3)4]-induced ECD spectra. Compound 1 showed moderate α-glucosidase inhibitory activities with IC50 values of 741.5 ± 2.83 μM. Compounds 6 and 11 exhibited DPPH scavenging activities with IC50 values of 15.36 ± 0.24 and 3.69 ± 0.07 μM, respectively.

scholarly journals New Andrastin-Type Meroterpenoids from the Marine-Derived Fungus Penicillium sp.

Marine Drugs ◽  
2021 ◽  
Vol 19 (4) ◽  
pp. 189
Author(s):  
Jinwei Ren ◽  
Ruiyun Huo ◽  
Gaoran Liu ◽  
Ling Liu
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Cell Lines ◽  
Sw480 Cell ◽  
Mass Spectrometric ◽  
Mass Spectrometric Analysis ◽  
Spectrometric Analysis ◽  
Penicillium Species ◽  
Penicillium Sp ◽  
New Compounds

Three new andrastin-type meroterpenoids penimeroterpenoids A–C (1–3) together with two known analogs (4 and 5) were isolated from the cultures of the marine-derived Penicillium species (sp.). The structures of the new compounds were elucidated on the basis of 1- and 2-dimensional (1D/2D) Nuclear Magnetic Resonance (NMR) spectroscopic and mass spectrometric analysis. The absolute configurations of 1–3 were determined by comparison of experimental and calculated electronic circular dichroism (ECD) spectra. Compound 1 showed moderate cytotoxicity against A549, HCT116, and SW480 cell lines.

scholarly journals A New Arylnaphthalide Lignan From Oxalis corniculata

2019 ◽  
Vol 14 (9) ◽  
pp. 1934578X1987588
Author(s):  
Bao Zhang ◽  
Li Jiang ◽  
Xue Ma ◽  
Ai-Min Wang ◽  
Ting Liu ◽  
...  
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Chemical Structure ◽  
Mass Spectrometric ◽  
Mass Spectrometric Analysis ◽  
Spectrometric Analysis ◽  
Etoh Extract ◽  
Nuclear Magnetic

A new arylnaphthalide lignan, corniculin (1), was isolated from 75% EtOH extract of Oxalis corniculata. Its chemical structure was determined by mass spectrometric analysis as well as 1D and 2D nuclear magnetic resonance (NMR).

The Metabolism of 4′-Chloro-4-biphenylol in the Rat

1975 ◽  
Vol 53 (4) ◽  
pp. 415-420 ◽  
Author(s):  
S. Safe ◽  
O. Hutzinger ◽  
D. J. Ecobichon ◽  
A. A. Grey
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Degradation Products ◽  
Mass Spectrometric ◽  
Urinary Metabolite ◽  
Spectrometric Analysis ◽  
Resonance Spectroscopy ◽  
Major Urinary Metabolite ◽  
Metabolic Degradation ◽  
Sole Product

4′-Chloro-4-biphenylol, the major metabolite of 4-chlorobiphenyl in the rat, was given intraperitoneally to rats, and the urine and feces were examined for possible metabolic degradation products. The structure of the major urinary metabolite was elucidated by mass and nuclear magnetic resonance spectroscopy and shown to be 4′-chloro-3,4-biphenyldiol. Two chloromethoxybiphenylols (M+ 234) were also identified in the urine extracts but they could not be separated by chromatographic procedures. Demethylation of the mixture gave 4′-chloro-3,4-biphenyldiol as the sole product, thus indicating that the two components of the mixture were 4′-chloro-3-methoxy-4-biphenylol and 4′-chloro-4-methoxy-3-biphenylol. A fourth urinary metabolite was identified as 4′-chloro-4-methoxy-3,5-biphenyldiol. No 4′-chloro-4-biphenylol metabolites were isolated in the fecal extracts, and mass spectrometric analysis of the crude urine and feces extracts did not reveal any chlorine-containing degradation products that could be derived by oxidative fission of the biphenyl nucleus.

Étude conformationnelle de cétopipérazines: (I) 3R-méthyl-6-carbéthoxy-2 oxopipérazine, (II) 3R-[p-hydroxybenzyl]-6-carbéthoxy-2 oxopipérazine: I, II en solution et structure cristalline de II

1987 ◽  
Vol 65 (6) ◽  
pp. 1308-1312 ◽  
Author(s):  
André Michel ◽  
Guy Evrard ◽  
B. Norberg
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Absolute Configuration ◽  
Structure Determination ◽  
Opiate Receptor ◽  
Receptor Level ◽  
X Ray ◽  
Diastereomeric Mixture ◽  
The Absolute

The synthesis of the title compounds has been described recently. It was anticipated that the product would be a diastereomeric mixture. Surprisingly, only one isomer was obtained. The present work is an attempt to find the conformationnal properties accounting for those observations. X-ray structure determination of 3R-[p-hydroxybenzyl]-6-carbethoxy-2-oxopiperazine shows that the molecule adopts a folded conformation and that the absolute configuration at C6 is [R]. Investigation in solution using 1H nuclear magnetic resonance shows the existence of three conformers and discusses the relative populations. Those findings are also relevant in terms of the activity of such compounds at the opiate receptor level.

Carbon-13 nuclear magnetic resonance spectrometric and gas chromatography/mass spectrometric characterization of lipids in corn suspension cells

1985 ◽  
Vol 57 (3) ◽  
pp. 710-715 ◽  
Author(s):  
Dennis James. Ashworth ◽  
Douglas Owen. Adams ◽  
Benjamin Yunwen. Giang ◽  
Michael Tung Hai. Cheng ◽  
Rino Yul. Lee
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Gas Chromatography ◽  
Magnetic Resonance ◽  
Mass Spectrometric ◽  
Suspension Cells ◽  
Nuclear Magnetic
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