Neurosarcoidosis with Intraparenchymal Cystic Lesions

2008 ◽  
Vol 21 (6) ◽  
pp. 810-816 ◽  
Author(s):  
F.A. Al Hajri ◽  
A.T. Muqim ◽  
T.J.E. Muttikkal
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Rare Case ◽  
Clinical Manifestations ◽  
Central Nervous System Involvement ◽  
Unknown Etiology ◽  
Cystic Lesions ◽  
Imaging Appearance ◽  
Granulomatous Disorder ◽  
The Right

Sarcoidosis is a chronic multi-system granulomatous disorder of unknown etiology. Central nervous system involvement is relatively uncommon in sarcoidosis. Clinical manifestations and radiological appearances of neurosarcoidosis vary widely depending on the site and activity of the lesions. In most cases, the imaging appearance is nonspecific. We report a very rare case of extensive neurosarcoidosis with progressively enlarging cystic lesions in the right temporal lobe.

scholarly journals Trigeminal ganglion involvement in sarcoidosis

2018 ◽  
Vol 20 (4) ◽  
pp. 439-441
Author(s):  
Jairo Silva Dos Ângelos ◽  
Guilherme Brasileiro De Aguiar ◽  
Edgar Manuel Garcete Fariña ◽  
Maud Parise ◽  
Alexandre Martins Cunha ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Magnetic Resonance ◽  
Parietal Cortex ◽  
Central Nervous System Involvement ◽  
Corticosteroid Treatment ◽  
Unknown Etiology ◽  
Histopathological Study ◽  
Gasserian Ganglion ◽  
The Right

Sarcoidosis is a disease of unknown etiology presenting as noncaseating granulomatous infiltration in tissues. Central Nervous system is rarely affected , usually as dissemination from other organs, mainly lungs. We report on a case in which the patient had only central nervous system involvement, presenting with a mass in the right gasserian ganglion and another lesion in right parietal cortex, observed in magnetic resonance. Diagnosis was given by histopathological study of the lesion and the patient improved with corticosteroid treatment.

scholarly journals Acute exudative polymorphous paraneoplastic vitelliform maculopathy (AEPPVM) associated with choroidal melanoma

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Aluisio Rosa Gameiro Filho ◽  
Guilherme Sturzeneker ◽  
Ever Ernesto Caso Rodriguez ◽  
André Maia ◽  
Melina Correia Morales ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Serous Retinal Detachment ◽  
Central Nervous System Involvement ◽  
Choroidal Melanoma ◽  
Posterior Pole ◽  
Pancreatic Metastasis ◽  
Small Areas ◽  
History Of ◽  
The Right

Abstract Background To report a case of acute exudative polymorphous paraneoplastic vitelliform maculopathy in a patient with a history of choroidal melanoma, with metastases to the pancreas, liver, and central nervous system. Case presentation A 63-year-old patient, with a history of enucleation of the right eye due to choroidal melanoma, complained of progressive visual loss during a follow-up visit. Fundoscopic examination revealed multiple small areas of serous retinal detachment scattered throughout the posterior pole and ancillary tests confirmed the diagnosis of acute exudative polymorphous paraneoplastic vitelliform maculopathy (AEPPVM). Screening for systemic metastases showed pancreatic, hepatic, and central nervous system involvement. Conclusions We describe a rare case of acute exudative polymorphous paraneoplastic vitelliform maculopathy, which should be considered in patients with or without a history of melanoma, who have vitelliform retinal detachments. Nevertheless, no previous reviews of literature have shown a correlation between AEPPVM and pancreatic metastasis.

scholarly journals Pulmonary and Central Nervous System Involvement in Sweet's Syndrome: A Very Rare Case Report

2008 ◽  
Vol 47 (16) ◽  
pp. 1481-1484 ◽  
Author(s):  
Hande Aydemir ◽  
Nefise Öztoprak ◽  
Güven Celebi ◽  
Cevdet Altinyazar ◽  
Figen Barut ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Case Report ◽  
Rare Case ◽  
Central Nervous System Involvement ◽  
Sweet’S Syndrome ◽  
Sweet's Syndrome ◽  
System Involvement ◽  
Rare Case Report

scholarly journals Towards Central Nervous System Involvement in Adults with Hereditary Myopathies

2020 ◽  
Vol 7 (4) ◽  
pp. 367-393
Author(s):  
Jens Reimann ◽  
Cornelia Kornblum
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Neuromuscular Disorders ◽  
Clinical Manifestations ◽  
Specific Treatment ◽  
Central Nervous System Involvement ◽  
Epileptic Seizures ◽  
System Involvement ◽  
History Of ◽  
Neuroimaging Techniques

There is increasing evidence of central nervous system involvement in numerous neuromuscular disorders primarily considered diseases of skeletal muscle. Our knowledge on cerebral affection in myopathies is expanding continuously due to a better understanding of the genetic background and underlying pathophysiological mechanisms. Intriguingly, there is a remarkable overlap of brain pathology in muscular diseases with pathomechanisms involved in neurodegenerative or neurodevelopmental disorders. A rapid progress in advanced neuroimaging techniques results in further detailed insight into structural and functional cerebral abnormalities. The spectrum of clinical manifestations is broad and includes movement disorders, neurovascular complications, paroxysmal neurological symptoms like migraine and epileptic seizures, but also behavioural abnormalities and cognitive dysfunction. Cerebral involvement implies a high socio-economic and personal burden in adult patients sometimes exceeding the everyday challenges associated with muscle weakness. It is especially important to clarify the nature and natural history of brain affection against the background of upcoming specific treatment regimen in hereditary myopathies that should address the brain as a secondary target. This review aims to highlight the character and extent of central nervous system involvement in patients with hereditary myopathies manifesting in adulthood, however also includes some childhood-onset diseases with brain abnormalities that transfer into adult neurological care.

scholarly journals Rare Case of Sarcoidosis Presenting As Bilateral Iridocyclitis

2018 ◽  
Vol 2 (3) ◽  
Keyword(s):  
Rare Case ◽  
Final Diagnosis ◽  
Acute Onset ◽  
Unknown Etiology ◽  
Slit Lamp ◽  
Prevalence Studies ◽  
Laboratory Investigations ◽  
Granulomatous Disorder ◽  
Asymptomatic Case ◽  
The Right

Background: A case of acute onset bilateral iridocyclitis is reported in a previously undiagnosed and asymptomatic case of sarcoidosis. Case: A 39 years old male presented with pain and redness in the right eye for one day. Slit lamp examination revealed granulomatous iridocyclitis in the eye with three hundred sixty degree posterior synechiae. While under investigation for the cause, on fourth day of initial presentation, left eye also developed similar granulomatous iridocyclitis, being symptomatic only overnight. All laboratory investigations, radiological evaluation and biopsy led to the final diagnosis of sarcoidosis. Conclusion: Sarcoidosis is a multisystem granulomatous disorder of unknown etiology which may present as an acute uveitis or chronic form. As definite prevalence studies are not available, it should be considered in the differential diagnosis of all cases of uveitis in Nepal.

Peripheral neuropathies and motor neuron disorders

2017 ◽  
pp. 871-878
Author(s):  
Stéphane Mathis ◽  
Jean-Michel Vallat
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Peripheral Nervous System ◽  
Motor Neurons ◽  
Central Nervous System Involvement ◽  
Nerve Biopsy ◽  
Motor Disorder ◽  
Peripheral Neuropathies ◽  
The Right ◽  
Lateral Sclerosis

Peripheral nervous system disorders are common in older people. Most peripheral neuropathies are secondary to metabolic (diabetes) or toxic causes (medications, alcohol), but several other aetiologies are possible, requiring clinical, electrophysiological, biological, and sometimes pathological (nerve biopsy) examinations to make the right diagnosis and instigate effective treatments. However, despite using this strategy, no cause is found in some axonal polyneuropathies, leading to the concept of chronic idiopathic axonal polyneuropathy (CIAP). Amyotrophic lateral sclerosis (ALS) affects the peripheral nervous system, but is also characterized by central nervous system involvement: it is a strictly motor disorder affecting both the first and second motor neurons, usually presenting during the sixth or seventh decade. This rapidly progressive, still incurable neurodegenerative disease leads to death in all cases.

scholarly journals Sacral Chordoma Metastatic to Bilateral Clavicle - A Rare Clinical Presentation and Review of Literature

2013 ◽  
Vol 4 (4) ◽  
pp. 24-27
Author(s):  
Rashi Agrawal ◽  
Sudarsan De ◽  
Alpana Srivastava ◽  
Sweety Gupta ◽  
Dinesh Singh ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Rare Case ◽  
Clinical Presentation ◽  
Medical Science ◽  
Central Nervous System Involvement ◽  
Science Volume ◽  
Review Of Literature ◽  
Sacral Chordoma ◽  
Uncommon Tumor

Chordoma is an uncommon tumor , so the metastatic cases generally are given more attention. Various cases with central nervous system involvement, cutaneous and mandible metastases have been reported. Metastases to bone is noted in literature but metastases to bilateral clavicle is not reported yet to the best of our knowledge. We hereby present a rare case of sacral chordoma with clavicular metastases. Asian Journal of Medical Science, Volume-4 (2013), Pages 24-27 DOI: http://dx.doi.org/10.3126/ajms.v4i4.7999 

scholarly journals Central nervous system manifestations of mucormycosis

2021 ◽  
Vol 8 (1) ◽  
pp. 42
Author(s):  
Ishita A. Shah ◽  
Niral R. Modi
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Sinus Thrombosis ◽  
Radiological Finding ◽  
Clinical Manifestations ◽  
Central Nervous System Involvement ◽  
Surgical Debridement ◽  
Clinical Feature ◽  
The Central Nervous System ◽  
Diagnostic Modalities

<p><strong>Background:</strong> There has been an unprecedented increase in the number of mucormycosis cases post the second wave of COVID-19 in India, with a variety of clinical manifestations. The central nervous system manifestations have proven to be especially fatal, hence these require special attention. Aims and objectives of current investigation was to study the epidemiology, clinical features, risk factors, diagnostic modalities, management and complications of CNS manifestations of mucormycosis.</p><p><strong>Methods:</strong> This is a retrospective study, conducted on the mucormycosis patients admitted in G.G. hospital Jamnagar. Patients with clinically and radiologically evident central nervous system involvement were included in the study. The records of the patients were followed for 3 months post the diagnosis. 47 patients were included in the study.</p><p><strong>Results:</strong> The mean age of the patients was 51 years. 72.34% of patients were males, and 27.65%, were females. The most common clinical feature was headache 100% followed by fever 55%. Most of the patients (97.87%) had history of COVID 19 or had active infection. 63.96% had diabetes Mellitus. The most common radiological finding was cavernous sinus thrombosis (32.60%), 72.34% underwent surgical debridement, and all the patients were administered Amphotericin B. The outcome improved significantly with surgical debridement, with recovery seen in 51.06% patients.</p><p><strong>Conclusions:</strong> There has been a steep rise in the cases of mucormycosis following the COVID-19 pandemic. It is an extremely virulent infection which spreads rapidly, often causing the involvement of the central nervous system. However, early diagnosis and intervention have been found to alter the prognosis significantly.</p>

scholarly journals A Neurotoxocariasis Case Manifesting Multiple Cerebral Infarction and Eosinophilic Meningoencephalitis

2021 ◽  
Vol 39 (4) ◽  
pp. 331-335
Author(s):  
SangJoon Kang ◽  
Jaeyoung Park ◽  
Hoe Jong Jeong ◽  
Jae-Jeong Joo ◽  
Seungmin Kim
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Cerebral Infarction ◽  
Clinical Symptoms ◽  
Clinical Manifestations ◽  
Central Nervous System Involvement ◽  
Toxocara Canis ◽  
Increased Intracranial Pressure ◽  
Multiple Cerebral Infarction ◽  
Eosinophilic Meningoencephalitis

Although Toxocara canis is known to cross the blood-brain barrier, central nervous system involvement is uncommon. Clinical manifestations vary and include cerebral infarction, meningoencephalitis, myelitis, vasculitis or seizure. However cerebral infarction and meningoencephalitis rarely occur simultaneously. We report a case of multiple cerebral infarction combined with eosinophilic meningoencephalitis in a patient with neurotoxocariasis. After control of increased intracranial pressure and treatment with albendazole and steroid, the patient’s clinical symptoms improved markedly.

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