scholarly journals The novel use of clozapine in an adolescent with borderline personality disorder

2014 ◽  
Vol 4 (4) ◽  
pp. 149-155 ◽  
Author(s):  
Sarah Elizabeth Argent ◽  
Simon Alastair Hill
2019 ◽  
Author(s):  
Sarah Kathryn Fineberg ◽  
Jason C. Hu ◽  
Kaylee Null ◽  
Eli S. Neustadter ◽  
Madison Sakheim ◽  
...  

Borderline personality disorder (BPD) is associated with deficits in neuropsychological measures such as memory, cognitive flexibility, and learning. Mixed findings suggest that deficits may be specific to particular aspects of learning. This is the first study to examine Kamin blocking in a BPD sample. A sample of 51 female subjects (N = 24 control, N = 27 BPD) were recruited. Participants completed a learning task in three phases: a first acquisition phase to learn cue-outcome associations, a second pairing phase to set up blocked cues, and a third testing phase to measure the extent of blocking and to test reversal learning. Participants indicated choice and certainty at each trial, and received feedback immediately after each trial. In phase one, mean correctness but not learning rate was less in BPD than control. Participants with BPD were also less certain about their responses, which correlated positively with correctness – this correlation was not found for control subjects. Kamin blocking, maintenance of previous learning, and reversal learning did not differ between groups. These results cohere with the idea that learning deficits in BPD are in specific domains, including the novel finding that Kamin blocking is preserved in BPD. The significant correlation between certainty and correctness in BPD may hint at mechanisms underlying the maintenance of low mood.


Crisis ◽  
2020 ◽  
pp. 1-7
Author(s):  
Jacqueline M. Frei ◽  
Vladimir Sazhin ◽  
Melissa Fick ◽  
Keong Yap

Abstract. Psychiatric hospitalization can cause significant distress for patients. Research has shown that to cope with the stress, patients sometimes resort to self-harm. Given the paucity of research on self-harm among psychiatric inpatients, a better understanding of transdiagnostic processes as predictors of self-harm during psychiatric hospitalization is needed. The current study examined whether coping styles predicted self-harm after controlling for commonly associated factors, such as age, gender, and borderline personality disorder. Participants were 72 patients (mean age = 39.32 years, SD = 12.29, 64% male) admitted for inpatient treatment at a public psychiatric hospital in Sydney, Australia. Participants completed self-report measures of coping styles and ward-specific coping behaviors, including self-harm, in relation to coping with the stress of acute hospitalization. Results showed that younger age, diagnosis of borderline personality disorder, and higher emotion-oriented coping were associated with self-harm. After controlling for age and borderline personality disorder, higher levels of emotion-oriented coping were found to be a significant predictor of self-harm. Findings were partially consistent with hypotheses; emotion-oriented but not avoidance-oriented coping significantly predicted self-harm. This finding may help to identify and provide psychiatric inpatients who are at risk of self-harm with appropriate therapeutic interventions.


2017 ◽  
Vol 33 (2) ◽  
pp. 123-128 ◽  
Author(s):  
Anne van Alebeek ◽  
Paul T. van der Heijden ◽  
Christel Hessels ◽  
Melissa S.Y. Thong ◽  
Marcel van Aken

Abstract. One of the most common personality disorders among adolescents and young adults is the Borderline Personality Disorder (BPD). The objective of current study was to assess three questionnaires that can reliably screen for BPD in adolescents and young adults (N = 53): the McLean Screening Instrument for BPD (MSI-BPD; Zanarini et al., 2003 ), the Personality Diagnostic Questionnaire 4th edition – BPD scale (PDQ-4 BPD; Hyler, 1994 ), and the SCID-II Patient Questionnaire – BPD scale (SCID-II-PQ BPD). The nine criteria of BPD according to the Diagnostic and Statistical Manual of Mental Disorders-IV (DSM-IV; APA, 1994 ) were measured with the Structural Clinical Interview for DSM-IV Axis II disorders – BPD scale (SCID-II; First, Spitzer, Gibbon, Williams, & Benjamin, 1995 ). Correlations between the questionnaires and the SCID-II were calculated. In addition, the sensitivity and specificity of the questionnaires were tested. All instruments predicted the BPD diagnosis equally well.


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