Chronic fatigue syndrome (CFS)/Myalgic Encephalomyelitis (ME) and Fibromyalgia (FM): the foundation of a relationship

Introduction: Chronic fatigue syndrome (CFS)/Myalgic Encephalomyelitis (ME) and fibromyalgia (FM) are both debilitating syndromes with complex polysymptomatology. Early research infers that a relationship may exist even though the diagnosis provided may influence the management trajectory. In the absence of a diagnostic test and treatment, this study aims to confirm the symptoms and their severity, which may infer a relationship and influence future research. Method: A quasi-experimental design was utilised, using Internet-based self-assessment questionnaires focusing on nine symptom areas: criteria, pain, sleep, fatigue, anxiety and depression, health-related quality of life, self-esteem and locus of control. The questionnaires used for data collection are as follows: the American Centre for Disease Control and Prevention Symptom Inventory for CFS/ME (American CDC Symptom Inventory); the American College of Rheumatology (ACR) Criteria for FM; Fibromyalgia Impact Questionnaire (FIQ); McGill Pain Questionnaire (MPQ); Multidimensional Fatigue Inventory (MFI); Pittsburgh Sleep Quality Index (PSQI); Health-Related Quality of Life SF-36 V2 (HRQoL SF-36 V2); Hospital Anxiety and Depression Scale (HADS); Multidimensional Health Locus of Control (MHLOC) and the Rosenberg Self-Esteem Scale (RSES). Setting and participants: Participants were recruited from two distinct community groups, namely CFS/ME (n = 101) and FM (n = 107). Participants were male and female aged 17 (CFS/ME mean age 45.5 years; FM mean age 47.2 years). Results: All participants in the CFS/ME and FM groups satisfied the requirements of their individual criteria. Results confirmed that both groups experienced the debilitating symptoms measured, with the exception of anxiety and depression, impacting on their quality of life. Results suggest a relationship between CFS/ME and FM, indicating the requirement for future research.

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Mo1831 - Chronic Fatigue in Patients with Inflammatory Bowel Disease is Associated with Lower Health-Related Quality of Life, Low Self-Esteem, and Increased Anxiety and Depression

Gastroenterology ◽

10.1016/s0016-5085(18)32795-1 ◽

2018 ◽

Vol 154 (6) ◽

pp. S-818

Author(s):

Randi Opheim ◽

Lars-Petter Jelsness-Jørgensen ◽

Tomm Bernklev ◽

Jorgen Jahnsen ◽

Svein Oskar Frigstad ◽

...

Keyword(s):

Quality Of Life ◽

Chronic Fatigue ◽

Self Esteem ◽

Anxiety And Depression ◽

Health Related Quality ◽

Related Quality ◽

Health Related ◽

Lower Health ◽

Inflammatory Bowel

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P208 Chronic fatigue in patients with inflammatory bowel disease is associated with lower health–related quality of life, low self-esteem, increased anxiety and depression

Journal of Crohn s and Colitis ◽

10.1093/ecco-jcc/jjx180.335 ◽

2018 ◽

Vol 12 (supplement_1) ◽

pp. S204-S205 ◽

Cited By ~ 1

Author(s):

R Opheim ◽

T Bernklev ◽

J Jahnsen ◽

T Grimstad ◽

Ø Hovde ◽

...

Keyword(s):

Quality Of Life ◽

Chronic Fatigue ◽

Self Esteem ◽

Anxiety And Depression ◽

Health Related Quality ◽

Related Quality ◽

Health Related ◽

Lower Health ◽

Inflammatory Bowel

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Development of a conceptual framework to underpin a health-related quality of life outcome measure in paediatric chronic fatigue syndrome/myalgic encephalopathy (CFS/ME): prioritisation through card ranking

Quality of Life Research ◽

10.1007/s11136-019-02399-z ◽

2020 ◽

Vol 29 (5) ◽

pp. 1169-1181

Author(s):

Roxanne M. Parslow ◽

Nina Anderson ◽

Danielle Byrne ◽

Kirstie L. Haywood ◽

Alison Shaw ◽

...

Keyword(s):

Quality Of Life ◽

Conceptual Framework ◽

Outcome Measure ◽

Chronic Fatigue ◽

Health Related Quality ◽

Fatigue Syndrome ◽

Related Quality ◽

Health Related ◽

Ranking Exercise

Abstract Purpose Chronic fatigue syndrome (CFS)/myalgic encephalopathy (ME) is relatively common in children and is disabling at an important time in their development. This study aimed to develop a conceptual framework of paediatric CFS/ME using the patient-perspective to ensure that the content of a new outcome measure includes the outcomes most important to young people. Methods We developed a child-centred interactive card ranking exercise that included health-related quality of life (HRQoL) outcomes identified from a previous review of the literature as well as qualitative work. Adolescents and their parents selected and ranked the outcomes most important to them and discussed each outcome in further detail. Adolescents were purposively sampled from a single specialist paediatric CFS/ME service in England. Interviews were audio recorded and transcribed verbatim, and thematic framework analysis was used to develop the final conceptual framework. Results We interviewed 43 participants in which there are 21 adolescents, 12–17 years of age with mild–moderate CFS/ME and their parents (20 mothers and 2 fathers). ‘Symptoms’, ‘tiredness’, ‘payback and crashing’ and ‘activities and hobbies’ were ranked most important to improve by both children and parents. Children ranked ‘school’ higher than parents and parents ranked ‘mood’ higher than children. A youth- specific CFS/ME conceptual framework of HRQoL was produced that included 4 outcome domains and 11 subdomains: sleep, tiredness, problems concentrating, individual symptoms, fluctuation and payback, daily and general activities, participation in school, leisure and social life, mood, anxiety and self-esteem. Conclusions An interactive card ranking exercise worked well for adolescents aged 12–17 to elicit the most important outcomes to them and explore each domain in further detail. We developed a final conceptual framework of HRQoL that forms the basis of a new paediatric patient-reported outcome measure (PROM) in CFS/ME.

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