scholarly journals Verrucous plane xanthomas secondary to lipoprotein X dyslipidemia in the context of cholestatic fulminant hepatitis: A case report

2021 ◽  
Vol 9 ◽  
pp. 2050313X2110579
Author(s):  
Julie Dang ◽  
Darosa Lim ◽  
Kevin Watters ◽  
Olivier Simard ◽  
Karine Doyon ◽  
...  
Keyword(s):  
Fulminant Hepatitis ◽  
Rare Case ◽  
Hepatitis A ◽  
Cholestatic Liver Disease ◽  
Atypical Presentation ◽  
Epidermal Hyperplasia ◽  
Rare Form ◽  
Lipid Panel ◽  
Atypical Presentations ◽  
Disorders Of Lipid Metabolism

Cutaneous xanthomas are the result of dermal deposition of lipid, mostly caused by disorders of lipid metabolism. Less commonly, they occur in the setting of cholestatic liver disease, leading to accumulation of lipoprotein X, a rare form of dyslipidemia that does not respond well to conventional treatments. We describe an atypical presentation of sudden diffuse xanthomas secondary to lipoprotein X dyslipidemia in the context of cholestatic fulminant hepatitis caused by trimethoprim-sulfamethoxazole hypersensitivity. Histopathology was also atypical and showed an unusual verrucous appearance consisting of overlying epidermal hyperplasia with hyperkeratosis. Our patient had significant improvement, after normalization of her lipid panel under cholestyramine and 13 sessions of apheresis, with topical corticosteroids offering some relief. This rare case shows the importance of recognizing atypical presentations of xanthomas, particularly when they do not respond to conventional dyslipidemia treatments.

scholarly journals Isolated Sacrococcygeal Tuberculosis, A Case Report Of A Rare Atypical Presentation

2019 ◽  
Vol 1 (4) ◽  
Author(s):  
Daksh Gadi ◽  
Saket Nigam ◽  
Deepti Gupta ◽  
Akanksha Sinha
Keyword(s):  
Case Report ◽  
Rare Case ◽  
Clinical Suspicion ◽  
Atypical Presentation ◽  
Rare Entity ◽  
Hematogenous Spread ◽  
Major Health Problem ◽  
Major Health ◽  
Rare Case Report ◽  
Atypical Presentations

Tuberculosis is a major health problem in India and in view of rise in the MDR tuberculosis atypical presentations are getting commoner these days and are difficult to diagnose. Musculoskeletal tuberculosis is very common among the  hematogenous spread cases of pulmonary tuberculosis involving thoracic spine the most. Involvement of sacrum and coccyx is rarest of  the possibility and isolated sacrococcygeal tuberculosis thus is very rare. Being a rare entity a high index of clinical suspicion is required to diagnose it. We hereby report a very rare case report of sacrococcygeal tuberculosis.

scholarly journals Atypical presentations of hepatitis A infection in children

2021 ◽  
Vol 61 (6) ◽  
pp. 317-21
Author(s):  
Sayma Rahman Munmun ◽  
Archana Shrestha Yadav ◽  
Mohammad Benzamin ◽  
Abu Sayed Mohammad Bazlul Karim ◽  
Mohammad Rukunuzzaman ◽  
...  
Keyword(s):  
Hepatic Encephalopathy ◽  
Pleural Effusion ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
Hepatitis A ◽  
Hepatitis A Virus ◽  
Hemoglobin Level ◽  
Atypical Presentation ◽  
Related Factors ◽  
Atypical Presentations

Background Hepatitis A is the most common cause of acute viral hepatitis, with a typical simple, self-limiting course. But it is not free from complications. Atypical presentations, such as in the form of prolonged cholestasis, ascites, pleural effusion, relapsing hepatitis, or fulminant hepatic failure, pose challenges to disease management. Knowledge about varying presentations and identification of factors associated with atypical presentations will help to early diagnosis of atypical courses of disease. Objective To describe various atypical clinical presentations, biochemical findings of hepatitis A infection, and possible related factors. Methods Ninety-five children aged 1 to 18 years, diagnosed with hepatitis A infection, and admitted to the Department of Pediatric Gastroenterology & Nutrition, BSMMU, Dhaka, Bangladesh from January 2015 to May 2018 were studied retrospectively. Results Atypical presentations were manifested in 19 (20%) out of 95 children with hepatitis A virus (HAV) infection. The mean age of atypical patients [6.32 (SD 3.45) years] was significantly lower than that of typical patients [8.22 (SD 3.58) years] (P=0.0041). The most common atypical manifestation was ascites (11/19), followed by hepatic encephalopathy (9/19), acute liver failure (719), thrombocytopenia (2/19), pleural effusion (2/19), and cholestasis (1; 1.1%). Children with atypical features had significantly higher international normalized ratio (INR) and serum bilirubin, as well as lower hemoglobin level than the typical group. Children of atypical group had significantly higher number of organomegaly and coagulopathy. Conclusion Ascites, hepatic encephalopathy, acute liver failure, thrombocytopenia, pleural effusion, and prolonged cholestasis were common forms of atypical presentation. Younger age, organomegaly, higher bilirubin level, prolonged PT, and decreased hemoglobin level could be predictive of an atypical presentation of HAV in children.

Management of acute and fulminant hepatitis A

Vaccine ◽  
1992 ◽  
Vol 10 ◽  
pp. S21-S23 ◽  
Author(s):  
John O'Grady
Keyword(s):  
Fulminant Hepatitis ◽  
Hepatitis A

Fulminant hepatitis A: Coincidence or a new trend?

1998 ◽  
Vol 114 ◽  
pp. A1268
Author(s):  
A Kapur ◽  
EG Molina ◽  
MJ Rodriguez ◽  
KR Reddy ◽  
LJ Jeffers ◽  
...  
Keyword(s):  
Fulminant Hepatitis ◽  
Hepatitis A

P-406: Ofloxacin-induced fulminant hepatitis: a case report

2015 ◽  
Vol 6 ◽  
pp. S140-S141 ◽  
Author(s):  
C. Joyau ◽  
G. Veyrac ◽  
A. Deininger ◽  
L. Triquet ◽  
F. Delamarre Damier ◽  
...  
Keyword(s):  
Case Report ◽  
Fulminant Hepatitis ◽  
Hepatitis A

scholarly journals Fulminant Hepatitis A in a Patient with Severe Hyperthyroidism: Rapid Recovery from Hepatic Coma after Plasmapheresis and Total Thyroidectomy

2000 ◽  
Vol 85 (5) ◽  
pp. 1765-1769 ◽  
Author(s):  
Michael Enghofer ◽  
Klaus Badenhoop ◽  
Stefan Zeuzem ◽  
Andreas Schmidt-Matthiesen ◽  
Christoph Betz ◽  
...  
Keyword(s):  
Total Thyroidectomy ◽  
Fulminant Hepatitis ◽  
Hepatitis A ◽  
Hepatic Coma ◽  
Rapid Recovery

Experiences with acute kidney injury complicating non-fulminant hepatitis A

Nephrology ◽  
2008 ◽  
Vol 13 (6) ◽  
pp. 451-458 ◽  
Author(s):  
HYUN W KIM ◽  
MI H YU ◽  
JANG H LEE ◽  
JAI W CHANG ◽  
WON S YANG ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Fulminant Hepatitis ◽  
Hepatitis A ◽  
Kidney Injury

Recurrent transient loss of airway secondary to regurgitated pedunculated hypopharyngeal liposarcoma

2021 ◽  
Vol 14 (5) ◽  
pp. e240503
Author(s):  
Craig John Hickson ◽  
Omar Ahmed ◽  
Juliet Laycock ◽  
Robert Hone
Keyword(s):  
Airway Obstruction ◽  
Multidisciplinary Team ◽  
Rare Case ◽  
Atypical Presentation ◽  
Team Meetings ◽  
Acute Airway Obstruction ◽  
History Of ◽  
Transient Loss ◽  
Multidisciplinary Team Meetings

We describe a rare case of hypopharyngeal liposarcoma with an atypical presentation. The patient presented with a 3-month history of intermittent, transient acute airway obstruction. In between episodes, he was asymptomatic. A pedunculated tumour originating in the postcricoid region was seen to be suspended into the oesophagus and intermittently regurgitated into the larynx to cause airway obstruction. The lesion was endoscopically removed and examined histologically to confirm the diagnosis. On-going management of rare lesions such as this should be through multidisciplinary team meetings at a tertiary sarcoma centre.

scholarly journals Thoracic Kidney: Extremely Rare State of Aberrant Kidney

2015 ◽  
Vol 2015 ◽  
pp. 1-3 ◽  
Author(s):  
Mahdi Khoshchehreh ◽  
Omalbanin Paknejad ◽  
Mehrdad Bakhshayesh-Karam ◽  
Marzieh Pazoki
Keyword(s):  
Differential Diagnosis ◽  
Rare Case ◽  
Medical Literature ◽  
Management Options ◽  
Rare Form ◽  
Renal Ectopia ◽  
Diagnosis And Management

The thorax is the rarest place among all forms of renal ectopia. We report a rare case of an unacquired thoracic kidney. Only about 200 cases of the thoracic kidney have ever been reported in medical literature worldwide. In this paper we present the rarest form of nontraumatic nonhernia associated, truly ectopic thoracic kidney. The differential diagnosis and management options and classification of this rare form of aberrant kidney are discussed.

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