scholarly journals Association of multiple sclerosis and sudden sensorineural hearing loss

2016 ◽  
Vol 2 ◽  
pp. 205521731665215 ◽  
Author(s):  
S Atula ◽  
ST Sinkkonen ◽  
R Saat ◽  
T Sairanen ◽  
T Atula
Keyword(s):  
Multiple Sclerosis ◽  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Normal Population ◽  
Cranial Nerves ◽  
Sudden Sensorineural Hearing Loss ◽  
Sensorineural Hearing ◽  
University Hospital ◽  
Initial Symptom ◽  
Mri Findings

Background Multiple sclerosis (MS) may affect other cranial nerves besides the optic nerve. Sudden sensorineural hearing loss (SSHL), possibly caused by a deficit in the auditory tract, including the vestibulocochlear nerve, is sometimes associated with MS. Objectives We aimed to assess the incidence of SSHL among MS patients, its frequency as an initial symptom of MS, and magnetic resonance imaging (MRI) findings associated with SSHL in MS. Methods We collected retrospectively all patients diagnosed with MS and SSHL at the Helsinki University Hospital between 2004 and 2014. Patients with both diagnoses were re-evaluated using hospital medical records, audiograms and head MRI scans. Results A total of 2736 patients were diagnosed with MS, 1581 patients with SSHL, and 18 patients (0.7% of all MS patients) with both; two patients presented with SSHL as an initial symptom of MS. The annual incidence of SSHL was 59.8/100 000 (95% confidence interval (CI) 37.7–94.9) in MS patients, and 12.4/100 000 (95% CI 11.8–13.0) in the normal population. Conclusion SSHL is a rare symptom of MS and is even less frequent as an initial symptom. Its incidence in MS patients, however, markedly exceeds that in the normal population.

scholarly journals Sensorineural Hearing Loss as the Prominent Symptom in Meningeal Carcinomatosis

2021 ◽  
Vol 28 (5) ◽  
pp. 3240-3250
Author(s):  
Xiaoqin Huang ◽  
Yu Jia ◽  
Lidong Jiao
Keyword(s):  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Cranial Nerves ◽  
Case Fatality ◽  
Whole Brain Radiotherapy ◽  
Meningeal Carcinomatosis ◽  
Sensorineural Hearing ◽  
Initial Symptom ◽  
Brain Radiotherapy ◽  
Total Deafness

Sensorineural hearing loss (SNHL) has been reported rarely in patients with meningeal carcinomatosis (MC). We summarized the clinical data of eight MC patients with SNHL and 35 patients reported from publications. In the eight patients with SNHL, the medium onset age was 48 (range from 37 to 66) years and six (75%) were male. Seven (87.5%) suffered from headaches as the initial symptom, and they experienced SNHL during the first two months after the occurrence of headaches (0.5 to 2 months, average 1.5 months). The audiogram configuration was flat in three patients (37.5%) and showed total deafness in five patients (62.5%). The damage of cranial nerves VI (abducens) was observed in six patients (75%), and four patients (50%) had cranial nerves VII (facial) injury during the disease course. The percentage of damage of cranial nerves was higher than the patients without SNHL (VIth, 75.0% vs. 13.3%, p = 0.002 and VIIth 50.0% vs. 6.7%, p = 0.012). Four (50%) patients suffered from lung adenocarcinoma as primary tumor, two (25%) experienced stomach adenocarcinoma, one had colon cancer, and one patient was unknown. The symptom of SNHL improved after individualized therapy in four patients (focal radiotherapy and chemotherapy for three patients and whole brain radiotherapy for one patient), but all passed away from 2 to 11 months after diagnosis. Total deafness and flat hearing loss in audiogram were the common types of SNHL resulting from MC. MC patients with SNHL were more likely to suffer from the damage of other cranial nerves, especially to cranial nerves VI and VII. Treatment might improve SNHL, but not improve the case fatality rate.

scholarly journals The treatment for idiopathic sudden sensorineural hearing loss at Kitasato University Hospital in past 16 years.

2011 ◽  
Vol 54 (2) ◽  
pp. 169-175
Author(s):  
Hajime Sano ◽  
Hiroyuki Watanabe ◽  
Yuichi Ono ◽  
Takeshi Ino ◽  
Kentaro Ohashi ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Sudden Sensorineural Hearing Loss ◽  
Sensorineural Hearing ◽  
University Hospital

Sudden sensorineural hearing loss during oral anticoagulant therapy

2004 ◽  
Vol 118 (11) ◽  
pp. 872-876 ◽  
Author(s):  
Kathleen Mierzwa ◽  
Gerlind Schneider ◽  
Andreas Müller
Keyword(s):  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Anticoagulant Therapy ◽  
Oral Anticoagulant ◽  
Oral Anticoagulant Therapy ◽  
Vitamin K Antagonists ◽  
Sudden Sensorineural Hearing Loss ◽  
Sensorineural Hearing ◽  
University Hospital ◽  
Vascular Compromise

This study investigated the role of sudden sensorineural hearing loss (SSNHL) as a symptom in oral anticoagulant therapy with vitamin K antagonists (Phenprocoumon; Marcumar®, Falithrom®). Vascular compromise of the cochlea due to thrombosis, embolus, reduced blood flow or vasospasm is one of the four possible pathways that can lead to SSNHL. Oral anticoagulant therapy should prevent thrombosis; if it does not the question arises as to whether the anticoagulation is working, or the wrong hypothesis of vascular compromise has been made. Patients with SSNHL during oral anticoagulant therapy who were admitted tothe ENT Department of the University Hospital in Jena from 1998 to 2001 were included. The pure-tone audiograms and the prothrombin time (PT) values before and after the event of the SSNHL were evaluated. The study found 10 patients with SSNHL during oral anticoagulant therapy. Although the audiograms showed some improvement in the majority of cases, three cases showed almost no improvement in hearing. On admission, half of the patients showed a PT-value higher than 30 per cent and in nine cases a PT-value >30 per cent could be demonstrated at least once duringtesting. It was not possible to demonstrate a relationship between the SSNHL and oral anticoagulation. Vascular compromise cannot be excluded as a cause for sudden hearing loss in patients undergoing oral anticoagulant therapy. It is possible that oral anticoagulants influence the viscosity of the plasma leading to interference with the microcirculation in the inner ear. Further research into this area is currently being conducted.

Sudden Sensorineural Hearing Loss in Lupus Erythematosus Associated with Antiphospholipid Syndrome: Case Report and Review

2005 ◽  
Vol 114 (3) ◽  
pp. 214-218 ◽  
Author(s):  
Giacomo Ceroni Compadretti ◽  
Cristina Brandolini ◽  
Ignazio Tasca
Keyword(s):  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Lupus Erythematosus ◽  
Anticardiolipin Antibody ◽  
Anticardiolipin Antibodies ◽  
Sudden Sensorineural Hearing Loss ◽  
Sensorineural Hearing ◽  
Initial Symptom ◽  
Good Clinical Condition ◽  
The Right

Systemic lupus erythematosus is a disease of unknown cause that manifests with tissue and cellular alterations due to the deposition of antibodies and pathogenic immune complexes. The disease can be associated with anticardiolipin antibody syndrome, a disorder of recurrent vascular thrombosis and thrombocytopenia associated with a persistent anticardiolipin test positivity. In this report, we describe the case of a young woman affected by lupus erythematosus and positive for anticardiolipin antibodies who was brought to our observation for a sudden sensorineural hearing loss in the right ear. The patient was successfully treated with osmotic therapy and, 13 months after the initial symptom, is now in good clinical condition with no recurrence of the hearing loss and normal bilateral hearing. Together with a critical review of the pertinent literature, this rare clinical case led us to formulate some original comments.

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