scholarly journals A Single Liver Metastasis From Adenoid Cystic Carcinoma of the Parotid Gland: Case Report

2019 ◽  
Vol 7 ◽  
pp. 232470961987963
Author(s):  
Ines Zemni ◽  
Nesrine Tounsi ◽  
Imene Bouraoui ◽  
Maher Slimene ◽  
Ghada Sahraoui ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Liver Metastasis ◽  
Parotid Gland ◽  
Adenoid Cystic Carcinoma ◽  
Malignant Neoplasm ◽  
Salivary Gland Cancer ◽  
Review Of The Literature ◽  
Adenoid Cystic ◽  
Disease Free ◽  
Rare Situation

Adenoid cystic carcinoma is an uncommon malignant neoplasm of the salivary gland. Liver metastasis from salivary gland cancer is a rare situation. In this article, we report the case of a 29-year-old woman treated 5 years previously for adenoid cystic carcinoma of the parotid gland by surgery and radiotherapy, who presented for a large hypervascularized hepatic metastasis of 20 cm. After 3-cycle chemotherapy stability, hepatic surgery was successfully performed. The patient maintained disease-free period of 12 months after the surgical treatment. This rare case represents a therapeutic challenge for oncologists and surgeons. Through this case and a review of the literature, we try to better detail the management of this uncommon entity.

Two malignant salivary gland tumours of different type in one patient

1994 ◽  
Vol 108 (9) ◽  
pp. 798-800 ◽  
Author(s):  
A. Hosni ◽  
C. Fisher ◽  
P. Rhŷ-Evans
Keyword(s):  
Salivary Gland ◽  
Parotid Gland ◽  
Adenoid Cystic Carcinoma ◽  
Salivary Glands ◽  
Submandibular Gland ◽  
Histological Type ◽  
Salivary Gland Tumours ◽  
Adenoid Cystic ◽  
The Right ◽  
Left Parotid Gland

AbstractThe synchronous or metachronous occurrence of two tumours of the salivary glands in one patient is rare. These are mainly benign and of the same histological type. Here we report a 56-year-old man who developed a mucoepidermoid tumour of the left parotid gland four years after diagnosis of adenoid cystic carcinoma of the right submandibular gland. This combination of neoplasms has not to our knowledge been reported before.

PROSPERO: A study to determine the utility of focused genomic profiling to guide selection of drug therapy in salivary gland cancer.

2019 ◽  
Vol 37 (15_suppl) ◽  
pp. 6086-6086 ◽  
Author(s):  
Samuel Rack ◽  
Yonghan Li ◽  
Craig McKay ◽  
Andrew Wallace ◽  
Robert Metcalf
Keyword(s):  
Salivary Gland ◽  
Targeted Therapy ◽  
Adenoid Cystic Carcinoma ◽  
Minor Salivary Gland ◽  
Group Analysis ◽  
Salivary Gland Cancer ◽  
Genomic Profiling ◽  
Duct Carcinoma ◽  
Adenoid Cystic ◽  
Selection Of

6086 Background: For most patients with recurrent or metastatic salivary gland cancer (RM-SGC), there are no standard therapies. Many patients undergo genomic profiling to guide selection of targeted therapy. The MSK-IMPACT study applied a 468 gene next generation sequencing (NGS) panel, identifying actionable mutations in 34/114 patients (30%) with RM-SGC. Minimising cost will facilitate application within publically funded healthcare systems. We therefore sought to determine the utility of genomic profiling using a focused 24 gene targeted NGS panel to identify actionable mutations in RM-SGC with a sub-group analysis in adenoid cystic carcinoma (ACC) and non-ACC sub-types. Methods: From January 2017 to 2018, 125 patients with RM-SGC provided informed consent to an ethically approved study. Clinical and demographic characteristics were collected. DNA was extracted from FFPE samples and analysed using Qiagen GeneRead DNAseq Targeted Panel V2 in the Manchester Centre for Genomic Medicine Diagnostic Laboratory, an NHS clinically accredited lab. A custom bioinformatic pipeline was validated to detect single nucleotide variants and indels ( < 40bp) to 5% mutant allele frequency. Alterations were categorised following American College of Medical Genetics guidelines and Association for Molecular Pathology tiering. Results: DNA from 101 tumours (69 major, 32 minor salivary gland) was sequenced with 95% coverage at > 350x read depth over the target enrichment. 65 patients had adenoid cystic carcinoma (ACC) and 36 had non-ACC SGC. Median age was 55 years (range 18-80). 43 actionable alterations were identified in 33 patients within the following genes: TP53 (21%), PIK3CA (8%), ERBB2 (6%), PTEN (3%), BRAF (2%), EGFR (T790M) (1%), and AKT1 (1%). Targeted therapy was selected based on genomic findings in 12% of these patients. In ACC patients, actionable alterations were seen in 25% compared with 55% of non-ACC patients (9 adenocarcinoma, 5 salivary duct carcinoma, 3 carcinoma ex pleomorphic adenoma, 2 mucoepidermoid carcinoma and 1 myoepithelial carcinoma). Conclusions: This study identified actionable alterations in 33% of SGC patients using focused genomic profiling, demonstrating comparable utility to larger research panels. This focussed panel is being expanded to include emerging biomarkers such as NOTCH gene mutations, with NOTCH inhibitors currently in trials in ACC. Greater access to basket studies incorporating therapies matched to genomic alterations will maximise the clinical utility of this approach.

scholarly journals Metastatic Adenoid Cystic Carcinoma of Salivary Glands: Case Reports and Review of the Literature

1996 ◽  
Vol 3 (4) ◽  
pp. 336-342 ◽  
Author(s):  
Alexander S.D. Spiers ◽  
Dixie Lee W. Esseltine ◽  
John C. Ruckdeschel ◽  
Jack N.P. Davies ◽  
John Horton
Keyword(s):  
Salivary Gland ◽  
Pain Relief ◽  
Literature Review ◽  
Adenoid Cystic Carcinoma ◽  
Systemic Treatment ◽  
Case Reports ◽  
Review Of The Literature ◽  
Single Drug ◽  
Adenoid Cystic ◽  
Uncommon Tumor

Background Adenoid cystic carcinoma is an uncommon tumor of the salivary gland. Little has been published on the chemotherapy of this neoplasm. Methods The literature on this disease is reviewed, and data from seven unpublished cases are presented. Results Four patients received cyclophosphamide. One responded, and another had pain relief. The literature review did not identify any single drug or combination that might be regarded as the treatment of choice. Conclusions Systematic, multi-institutional studies are required to determine appropriate systemic treatment for metastatic adenoid cystic carcinoma of salivary gland origin.

Septal, widely infiltrative and clinically occult adenoid cystic carcinoma of the parotid gland

1997 ◽  
Vol 111 (5) ◽  
pp. 491-492 ◽  
Author(s):  
A. Coup ◽  
J. M. S. Williamson ◽  
J. W. A. Curley
Keyword(s):  
Salivary Gland ◽  
Parotid Gland ◽  
Adenoid Cystic Carcinoma ◽  
Clinical Setting ◽  
Salivary Gland Tumours ◽  
Adenoid Cystic

AbstractMost salivary gland tumours present with an obvious mass and are usually diagnosed clinically. We present a case of occult adenoid cystic carcinoma of the parotid which, due to its peculiar septal pattern of growth and complicated clinical setting. defied diagnosis for several years.

Simultaneous pleomorphic adenoma of the left parotid gland and adenoid cystic carcinoma of the contralateral sublingual salivary gland: a case report

2009 ◽  
Vol 13 (4) ◽  
pp. 221-224 ◽  
Author(s):  
Nick Papadogeorgakis ◽  
Evagelos F. Kalfarentzos ◽  
Christine Vourlakou ◽  
Fotini Malta ◽  
Dimitris Exarhos
Keyword(s):  
Salivary Gland ◽  
Case Report ◽  
Parotid Gland ◽  
Adenoid Cystic Carcinoma ◽  
Pleomorphic Adenoma ◽  
Adenoid Cystic ◽  
Left Parotid Gland

Adenoid cystic carcinoma of the sublingual salivary gland in a 16-year-old female – report of a case and review of the literature

1997 ◽  
Vol 111 (5) ◽  
pp. 485-488 ◽  
Author(s):  
M. R. McFall ◽  
G. H. Irvine ◽  
J. W. Eveson
Keyword(s):  
Salivary Gland ◽  
Case Report ◽  
Adenoid Cystic Carcinoma ◽  
Submandibular Gland ◽  
Review Of The Literature ◽  
Present Case Report ◽  
Adenoid Cystic ◽  
Wharton’S Duct

AbstractTumours of the sublingual salivary gland are exceptionally rare. The present case report describes an adenoid cystic carcinoma of the sublingual salivary gland occurring in a 16-year-old girl, in itself an uncommon event. In addition, an interesting feature of the presentation was obstruction of the ipsilateral submandibular gland due to involvement of Wharton's duct.

Adenoid Cystic Carcinoma of Minor Anterior Lingual Salivary Gland: Case Report and Review of the Literature

2007 ◽  
Vol 19 (1) ◽  
pp. 58-61
Author(s):  
Masato Yamaguma ◽  
Hideo Kurokawa ◽  
Kuniyuki Matsubara ◽  
Shoji Kanda ◽  
Hiroyuki Takahashi ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Case Report ◽  
Adenoid Cystic Carcinoma ◽  
Review Of The Literature ◽  
Adenoid Cystic

T-Cell receptor repertoire and genomic analysis of tracheal adenoid cystic carcinoma.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. e18576-e18576
Author(s):  
Fei Wang ◽  
Chengzhi Zhou ◽  
Xiaohong Xie ◽  
Ming Liu ◽  
Xinqing Lin ◽  
...  
Keyword(s):  
Salivary Gland ◽  
T Cell ◽  
Adenoid Cystic Carcinoma ◽  
Disease Free Survival ◽  
Shannon Index ◽  
High Rate ◽  
Smoking History ◽  
Salivary Gland Cancer ◽  
Cell Repertoire ◽  
Adenoid Cystic

e18576 Background: Tracheal adenoid cystic carcinoma (TACC) is the second type of cancer in bronchial tumors, has a high rate of postoperative recurrence and poor prognosis for which therapeutic targets are unavailable. Currently, studies were mostly about ACC of salivary gland. Our study is aim to elucidate genomic landscape and predict clinical biomarker of TACC. Methods: We performed whole-exome sequencing (WES), T cell repertoire sequencing (TCR) and immunohistochemistry (IHC) on tumor tissue samples and matched peripheral blood (PB) samples from TACC patients. All patients were followed up for their disease-free survival. Results: 13 cases were enrolled from 2010 to 2019. Median age of 13 TACCs was 35 yrs. 7 patients were female. 12 patients were stage I. In 8 WES samples, TCEB3CL (62%, 5/8), LPAR3 (50%, 4/8), ALPI (38%, 3/8), ARID1A (38%, 3/8) and BCOR (38%, 3/8) mutated most frequently. The median TMB was 3.67 (1.37-6.77) mutations/Mb. 1 patient showed microsatellite instability high (MSI-H). 2 patients with the highest TMB both had POLE mutations. We compared frequency of most mutated genes in our 8 samples with three different ACC types, including 935 ACC of salivary gland cancer, 76 ACC of the lung, and 38 ACC of breast cancer. 7 mutated frequently genes were found both in TACC and other types of ACCs, including ARID1A, BCOR, ARID1B, KMT2C, KMT2D, CREBBP and FAT3. 6 of them were more frequent in TACC. 7 FFPE tumors and 13 PB samples from 13 TACCs were used to investigate immune microenvironment. In 13 PB samples, TCR diversity (shannon index) and clonality was negatively associated with age (Pearson, r = -0.53, p = 0.06; r = 0.53, p = 0.06, respectively). There was no significant association between the other clinical characteristics (gender and smoking history) and any TCR parameter (clonality, clonotype, shannon index). Patients with lower clonotype number had longer DFS than those with higher clonotype number (15.0 vs 9.5 months, p < 0.001, 95% CI, 0.23-675.66, HR, 12.46), while shannon index and clonality was not significantly associated with DFS. Conclusions: The genetic mutations associated with TACC are different from those implicated in non-small cell lung cancer. TCR analysis as a useful of indicator of disease development and prognosis in TACC may be utilized to direct further immunotherapy.

scholarly journals Adenoid cystic carcinoma of accessory parotid gland: A case report and review of the literature

2020 ◽  
Vol 6 (4) ◽  
pp. 100188
Author(s):  
Antonio Romano ◽  
Carmelo Lo Faro ◽  
Giorgio Iaconetta ◽  
Umberto Committeri ◽  
Giovanni Audino ◽  
...  
Keyword(s):  
Case Report ◽  
Parotid Gland ◽  
Adenoid Cystic Carcinoma ◽  
Review Of The Literature ◽  
Adenoid Cystic ◽  
Accessory Parotid Gland
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