scholarly journals Merkel Cell Carcinoma With Isolated Pancreatic Metastasis

2021 ◽  
Vol 9 ◽  
pp. 232470962110274
Author(s):  
Prasanth Lingamaneni ◽  
Hisham Laswi ◽  
Aleksandar Krbanjevic ◽  
Krishna Moturi ◽  
Vatsala Katiyar ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Checkpoint Inhibitor ◽  
Sudden Cardiac Arrest ◽  
Abdominal Discomfort ◽  
Pancreatic Metastasis ◽  
Merkel Cell ◽  
Pancreatic Involvement ◽  
Cutaneous Neuroendocrine Carcinoma ◽  
Initial Resection

Merkel cell carcinoma (MCC) is a highly aggressive cutaneous neuroendocrine carcinoma, frequently associated with distant metastasis. However, recurrence of MCC manifesting with only pancreatic involvement is exceedingly rare. A 53-year-old man presented to our institution with abdominal discomfort 3 months after initial resection of chest wall MCC. Imaging revealed lesions in the pancreas and peripancreatic lymph nodes. Pathology obtained through endoscopic ultrasound confirmed recurrence of MCC. He underwent chemotherapy with cisplatin and etoposide, resulting in a complete resolution of the pancreatic lesions. Unfortunately, he passed away from sudden cardiac arrest while being in remission from MCC. Immunohistochemistry is crucial in differentiating MCC from primary pancreatic glandular and neuroendocrine tumors. While there are no definitive guidelines in the management of pancreatic lesions associated with MCC, checkpoint inhibitor immunotherapy is increasingly being used.

scholarly journals Aggressive Behaviour of Merkel Cell Carcinoma in a Kidney Transplant Patient Receiving Tacrolimus Treatment – Is There an Alternative in Immune Checkpoint Inhibitor Treatment?

2020 ◽  
pp. 1-4
Author(s):  
Giuseppina Gallucci ◽  
Anna Maria Bochicchio ◽  
Giuseppina Gallucci ◽  
Luigi Cagiano ◽  
Michele Grieco ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Immune Checkpoint ◽  
Aggressive Behaviour ◽  
Transplant Patient ◽  
Immune Checkpoint Inhibitor ◽  
Checkpoint Inhibitor ◽  
Kidney Transplant Patient ◽  
Merkel Cell ◽  
Transplant Patients

Background: Merkel cell carcinoma (MCC) is a rare skin neoplasm first described by Toker in 1972. The tumor usually presents in the sixth to seventh decade of life as a solitary reddish-brown to violaceous subcutaneous nodule on the head, neck, or the extremities. It is seen at an earlier age only in immunocompromised patients like transplant patients in immunosuppressive therapy. Thus, cancer has now become the second cause of death among transplant patients. The tumor growth is rapid in MCC patients, and for metastatic disease, no substantial benefit is obtained by chemotherapy. A new drug has recently become available, an immune checkpoint inhibitor (CPI), avelumab, that is able to delay disease progression significantly. However, there are no current guidelines for the use of immune checkpoint inhibitors in transplant patients. Case Presentation: We describe the case of a 55-year-old kidney transplant patient on immunosuppressive therapy with tacrolimus with an early occurrence of a Merkel cell carcinoma whose aggressive behaviour could not be hampered by Avelumab, due to fear of allograft rejection. Conclusion: CPI therapy is potentially lifesaving in advanced MCC. Further studies are urgently needed to test its benefit in this rapidly expanding field of post-transplant malignancies where there are only a few and less effective therapeutic options.

Update on eighth edition American Joint Committee on Cancer classification for Merkel cell carcinoma and histopathological parameters that determine prognosis

2019 ◽  
Vol 72 (5) ◽  
pp. 337-340 ◽  
Author(s):  
Celestine M Trinidad ◽  
Carlos A Torres-Cabala ◽  
Victor G Prieto ◽  
Phyu P Aung
Keyword(s):  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Treatment Options ◽  
Cancer Staging ◽  
Tnm Staging ◽  
Merkel Cell ◽  
Appropriate Treatment ◽  
The Usa ◽  
Cutaneous Neuroendocrine Carcinoma ◽  
Eighth Edition

Merkel cell carcinoma (MCC) is a rare primary cutaneous neuroendocrine carcinoma. The annual incidence of MCC is increasing in the USA. Timely diagnosis and proper staging of this tumour are crucial as MCC has high rates of regional recurrence and lymph node and distant metastasis. In this review, we outline the key differences between the tumor node metastasis (TNM) staging criteria for MCC in the seventh and eighth editions of the AJCC Cancer Staging Manual. We also discuss histopathological parameters that are not included in the eighth edition of the manual but have been shown in other studies to predict a worse prognosis in patients with MCC. Correct assessment and reporting of these clinically relevant histopathological parameters is of utmost importance for practising pathologists as management differs according to the stage of the tumour. This review aims to increase awareness of all these parameters, and proper recognition would guide the treating clinicians towards the most appropriate treatment options that can be given to patients.

Cases Series of Pancreatic Metastasis from Merkel Cell Carcinoma

2013 ◽  
Vol 108 ◽  
pp. S270-S271
Author(s):  
Yezaz Ghouri ◽  
Somashekar Krishna ◽  
William Ross
Keyword(s):  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Pancreatic Metastasis ◽  
Merkel Cell

scholarly journals Endoscopic ultrasound-guided fine needle biopsy of pancreatic metastasis from Merkel cell carcinoma

Endoscopy ◽  
2016 ◽  
Vol 48 (S 01) ◽  
pp. E199-E200
Author(s):  
Antonella Maimone ◽  
Maria Bianchi ◽  
Paola Lorenzini ◽  
Annalisa de Leone ◽  
Luca De Luca
Keyword(s):  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Endoscopic Ultrasound ◽  
Needle Biopsy ◽  
Fine Needle Biopsy ◽  
Pancreatic Metastasis ◽  
Merkel Cell ◽  
Ultrasound Guided ◽  
Fine Needle

scholarly journals Metastatic Merkel Cell Carcinoma Masquerading as Multiple Immune-Related Adverse Events

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Farees Saqlain ◽  
Sophia Z. Shalhout ◽  
Kevin S. Emerick ◽  
Tomas G. Neilan ◽  
Tatyana Sharova ◽  
...  
Keyword(s):  
Adverse Events ◽  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Regional Lymph Node ◽  
Lymph Node Involvement ◽  
High Rate ◽  
Merkel Cell ◽  
Node Involvement ◽  
Cutaneous Neuroendocrine Carcinoma ◽  
Cutaneous Adverse Event

Merkel cell carcinoma is a rare cutaneous neuroendocrine carcinoma with a high rate of regional and distant metastasis and mortality. Here, we report a novel case of Merkel cell carcinoma which presented as a primary lesion to the left cheek with regional lymph node involvement and was treated with pembrolizumab and radiation. Widely metastatic disease eventually revealed on autopsy clinically mimicked immune-related organ insult leading to management with immunosuppressants. The patient also had a biopsy-confirmed immune-related cutaneous adverse event during admission. The case highlights a rare circumstance in which disease progression masqueraded as multiple immune-related end-organ adverse events. Contribution of on-target anti-PD-1 toxicity remains a possibility.

Insulinoma-associated 1: A novel nuclear marker in Merkel cell carcinoma (cutaneous neuroendocrine carcinoma)

2017 ◽  
Vol 45 (2) ◽  
pp. 129-135 ◽  
Author(s):  
Patrick S. Rush ◽  
Jason N. Rosenbaum ◽  
Madhuchhanda Roy ◽  
Rebecca M. Baus ◽  
Daniel D. Bennett ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Neuroendocrine Carcinoma ◽  
Merkel Cell ◽  
Nuclear Marker ◽  
Cutaneous Neuroendocrine Carcinoma

Pancreatic metastasis from a Merkel cell carcinoma diagnosed by ultrasound-guided biopsy

2016 ◽  
Vol 39 (6) ◽  
pp. 395-397
Author(s):  
Ana García García de Paredes ◽  
Eduardo Tavío Hernández ◽  
Jose Ramón Foruny Olcina ◽  
Jose Montans Araujo ◽  
Daniel Boixeda de Miquel ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Pancreatic Metastasis ◽  
Merkel Cell ◽  
Ultrasound Guided ◽  
Guided Biopsy ◽  
Ultrasound Guided Biopsy
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