Is Vortioxetine an Advantageous Choice for Erectile Dysfunction? A Case Report

Commonly prescribed antidepressants are associated with sexual adverse effects predominantly reported as erectile dysfunction by men. The clinical dilemma of choosing the right antidepressant while not compromising the sexual functioning is an area of recent research. Few antidepressants, namely dapoxetine, bupropion, trazodone, and mirtazapine, have been reported to have minimal sexual adverse effects. Vortioxetine is a relatively newer antidepressant with clinical profile having minimal sexual and cognitive adverse effects. However, improvement in sexual dysfunction after treatment with vortioxetine has not been reported so far. We highlight the unique benefit of vortioxetine in improving sexual dysfunction in a case of major depressive disorder.

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Psychiatric shades of grey: mirtazapine-induced hair discoloration and hair loss

Irish Journal of Psychological Medicine ◽

10.1017/ipm.2015.71 ◽

2016 ◽

Vol 33 (3) ◽

pp. 175-178 ◽

Cited By ~ 1

Author(s):

M. Osman ◽

M. D. McCauley

Keyword(s):

Major Depressive Disorder ◽

Case Report ◽

Adverse Effects ◽

Depressive Disorder ◽

Hair Loss ◽

Temporal Relationship ◽

Relevant Literature ◽

Major Depressive ◽

Hair Colour ◽

Medical Reason

IntroductionMirtazapine is indicated in the treatment of major depressive disorder particularly in selective serotonin re-uptake inhibitors resistance. Its effect on hair loss is rare with no previous documented effect on hair colour.MethodReview of relevant literature and description of a case report of a 54-year-old male patient who developed alopecia and hair discoloration after initiation of mirtazapine treatment.ResultsUpon cessation of mirtazapine treatment full restoration of hair colour and regrowth of hair was attained within 10 weeks.DiscussionThere was clear temporal relationship between experiencing hair loss and commencing mirtazapine treatment. No other more likely medical reason to explain such experience was established. A noticeable restoration of the hair colour occurred following mirtazapine cessation.ConclusionMirtazapine is associated with hair discoloration and hair loss. The possibility of such distressing adverse effects needs to be conveyed to patients by clinicians and to be further explored by researchers.

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Effect of Vortioxetine vs. Escitalopram on Sexual Functioning in Adults with Well-Treated Major Depressive Disorder Experiencing SSRI-Induced Sexual Dysfunction

Journal of Sexual Medicine ◽

10.1111/jsm.12980 ◽

2015 ◽

Vol 12 (10) ◽

pp. 2036-2048 ◽

Cited By ~ 38

Author(s):

Paula L. Jacobsen ◽

Atul R. Mahableshwarkar ◽

Yinzhong Chen ◽

Lambros Chrones ◽

Anita H. Clayton

Keyword(s):

Major Depressive Disorder ◽

Sexual Dysfunction ◽

Depressive Disorder ◽

Sexual Functioning ◽

Major Depressive

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Editorial Comment on “The Effect of Vortioxetine vs. Escitalopram on Sexual Functioning in Adults with Well-Treated Major Depressive Disorder Experiencing SSRI-Induced Sexual Dysfunction”

Journal of Sexual Medicine ◽

10.1111/jsm.13000 ◽

2015 ◽

Vol 12 (10) ◽

pp. 2049-2050

Author(s):

Robert Taylor Segraves

Keyword(s):

Major Depressive Disorder ◽

Sexual Dysfunction ◽

Depressive Disorder ◽

Editorial Comment ◽

Sexual Functioning ◽

Major Depressive

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Sexual dysfunction among male patients on antidepressant theraphy

European Psychiatry ◽

10.1016/s0924-9338(11)73258-8 ◽

2011 ◽

Vol 26 (S2) ◽

pp. 1554-1554

Author(s):

V. Sibinovic ◽

S. Tosic-Golubovic ◽

G. Selimovic

Keyword(s):

Major Depressive Disorder ◽

Erectile Dysfunction ◽

Sexual Dysfunction ◽

Depressive Disorder ◽

Previous History ◽

Major Depressive ◽

Delayed Ejaculation ◽

Male Patients ◽

Loss Of Libido ◽

Somatic Diseases

IntroductionSexual dysfunction is common among individuals with major depressive disorder but not optimally treated often.ObjectivesThe aim of this study was to determine differece in sexual dysfunction among male patients on antidepressant theraphy.MethodsStadu group consisted of 69 male outpatients who met DSM IV criteria for Major depressive disorder; aged 21–65 (mean 46.3 years). Studu excluded patients: with a previous history of sexual dysfunction, somatic diseases, other psychiatric co morbid condition. They did not used medication able to cause sexual dysfunction unless antidepressants or medications to improve erectile dysfunction. The ASEX and HDRS scales were applied at a single interview.ResultsThe prevalence of sexual dysfunction observed was 66% patients, 57, 7% in group under 50 and 74, 3% in group being 50 years old or older.Sexual dysfunction, revealed by a high score on the ASEX scale (mean overall score of 26.9) was in group of patient over 50 years old. (p < 0, 01). There are no statistical, significant differences in the points obtained on the HDRS scores in both groups. (p < 0.01). Sexual dysfunction were reported more frequently in patients taking TCA (p < 0.005) or SSRIs (p < 0.001) compared to patients treated with mirtazapine.The use of TCA is associated with loss of libido and erectile dysfunction, SSRIs with delayed ejaculation as well as impairment of libido and arousal.ConclusionsFrequency of sexual dysfunction is higher in patients over 50 years. The less impact on sexual function have mirtazapine.

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