Aurora: a new direction for a new dawn

Blood ◽  
2012 ◽  
Vol 119 (2) ◽  
pp. 322-323
Author(s):  
Katayoun Rezvani
Keyword(s):  
T Cell Receptor ◽  
Aurora Kinase ◽  
Cell Receptor ◽  
Genetically Engineered ◽  
Target Antigen ◽  
Adoptive Therapy ◽  
Aurora Kinase A ◽  
Large Numbers ◽  
Kinase A ◽  
Gene Transfer Techniques

The use of gene transfer techniques to introduce TCR α/β genes that confer specificity for a target antigen offers the opportunity to produce large numbers of cancer-specific T cells for adoptive therapy.1 In this issue of Blood, Nagai and colleagues examine the feasibility of adoptive therapy using lymphocytes genetically engineered to express the T-cell receptor (TCR) for the leukemia-associated antigen Aurora kinase A (AURKA).2

scholarly journals A Functionally Superior Second-Generation Vector Expressing an Aurora Kinase-A-Specific T-Cell Receptor for Anti-Leukaemia Adoptive Immunotherapy

PLoS ONE ◽  
2016 ◽  
Vol 11 (6) ◽  
pp. e0156896
Author(s):  
Nicholas Paul Casey ◽  
Hiroshi Fujiwara ◽  
Kazushi Tanimoto ◽  
Sachiko Okamoto ◽  
Junichi Mineno ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Adoptive Immunotherapy ◽  
Second Generation ◽  
Aurora Kinase ◽  
Cell Receptor ◽  
Aurora Kinase A ◽  
Kinase A

scholarly journals Aurora kinase A-specific T-cell receptor gene transfer redirects T lymphocytes to display effective antileukemia reactivity

Blood ◽  
2012 ◽  
Vol 119 (2) ◽  
pp. 368-376 ◽  
Author(s):  
Kozo Nagai ◽  
Toshiki Ochi ◽  
Hiroshi Fujiwara ◽  
Jun An ◽  
Toshiaki Shirakata ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
T Cell Receptor ◽  
Cd8 T Cells ◽  
Aurora Kinase ◽  
Cell Receptor ◽  
Target Cells ◽  
Human Leukemia ◽  
Aurora Kinase A ◽  
Kinase A

Abstract Aurora kinase A (AURKA) is overexpressed in leukemias. Previously, we demonstrated that AURKA-specific CD8+ T cells specifically and selectively lysed leukemia cells, indicating that AURKA is an excellent target for immunotherapy. In this study, we examined the feasibility of adoptive therapy using redirected T cells expressing an HLA-A*0201–restricted AURKA207-215-specific T-cell receptor (TCR). Retrovirally transduced T cells recognized relevant peptide-pulsed but not control target cells. Furthermore, TCR-redirected CD8+ T cells lysed AURKA-overexpressing human leukemic cells in an HLA-A*0201–restricted manner, but did not kill HLA-A*0201+ normal cells, including hematopoietic progenitors. In addition, AURKA207-215-specific TCR-transduced CD4+ T cells displayed target-responsive Th1 cytokine production. Finally, AURKA207-215-specific TCR-transduced CD8+ T cells displayed antileukemia efficacy in a xenograft mouse model. Collectively, these data demonstrate the feasibility of redirected T cell–based AURKA-specific immunotherapy for the treatment of human leukemia.

Die Expression der Aurora Kinase A korreliert mit dem Wnt-Modulator RACGAP1 im Magenkarzinom

2015 ◽  
Vol 53 (08) ◽  
Author(s):  
J Bornschein ◽  
J Nielitz ◽  
I Drozdov ◽  
M Selgrad ◽  
T Wex ◽  
...  
Keyword(s):  
Aurora Kinase ◽  
Aurora Kinase A ◽  
Kinase A

scholarly journals Targeting Aurora kinase A and JAK2 prevents GVHD while maintaining Tregand antitumor CTL function

2017 ◽  
Vol 9 (372) ◽  
pp. eaai8269 ◽  
Author(s):  
Brian C. Betts ◽  
Anandharaman Veerapathran ◽  
Joseph Pidala ◽  
Hua Yang ◽  
Pedro Horna ◽  
...  
Keyword(s):  
Aurora Kinase ◽  
Aurora Kinase A ◽  
Kinase A

Inhibition of Aurora Kinase A enhances chemosensitivity of medulloblastoma cell lines

2010 ◽  
Vol 55 (1) ◽  
pp. 35-41 ◽  
Author(s):  
Ayman El-Sheikh ◽  
Rong Fan ◽  
Diane Birks ◽  
Andrew Donson ◽  
Nicholas K Foreman ◽  
...  
Keyword(s):  
Cell Lines ◽  
Aurora Kinase ◽  
Aurora Kinase A ◽  
Medulloblastoma Cell ◽  
Kinase A ◽  
Medulloblastoma Cell Lines

scholarly journals Aurora Kinase A Drives MTOC Biogenesis but Does Not Trigger Resumption of Meiosis in Mouse Oocytes Matured In Vivo1

2012 ◽  
Vol 87 (4) ◽  
Author(s):  
Petr Solc ◽  
Vladimir Baran ◽  
Alexandra Mayer ◽  
Tereza Bohmova ◽  
Gabriela Panenkova-Havlova ◽  
...  
Keyword(s):  
Aurora Kinase ◽  
Aurora Kinase A ◽  
Mouse Oocytes ◽  
Kinase A

1032 poster MLN8054, A NOVEL INHIBITOR OF AURORA KINASE A SENSITIZES ANDROGEN-RESISTANT PROSTATE CANCER MODELS TO RADIATION

2011 ◽  
Vol 99 ◽  
pp. S386
Author(s):  
L. Moretti ◽  
K. Niermann ◽  
S. Schleicher ◽  
K.W. Kim ◽  
P. Kopsombut ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Aurora Kinase ◽  
Aurora Kinase A ◽  
Cancer Models ◽  
Kinase A
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