Trimeric G protein-CARMA1 axis links smoothened, the hedgehog receptor transducer, to NF-κB activation in diffuse large B-cell lymphoma
Keyword(s):
B Cell
◽
Key Points Novel crosstalk between SMO and NF-κB representing additional level of NF-κB regulation independent of genetic constitutive activation. SMO activates NF-κB by recruiting Gαi and Gα12 to activate PKCβ/CARMA1 and assembling CARMA1/BCL10/MALT1/TRAF6 to SMO.