scholarly journals Postthrombotic syndrome and other outcomes of lower extremity deep vein thrombosis in children

Blood ◽  
2016 ◽  
Vol 128 (14) ◽  
pp. 1862-1869 ◽  
Author(s):  
Maria Laura Avila ◽  
Eleanor Pullenayegum ◽  
Suzan Williams ◽  
Natasha Yue ◽  
Peter Krol ◽  
...  
Keyword(s):  
Deep Vein Thrombosis ◽  
Lower Extremity ◽  
Postthrombotic Syndrome ◽  
Vein Thrombosis ◽  
Key Points ◽  
Deep Vein

Key Points The frequency of PTS, PE, and DVT recurrence was higher in children with Non-LR DVT than in children with LR DVT. Thrombus resolution, DVT triggering event, and sex were predictors of LE PTS in children.

scholarly journals Reduced incidence of vein occlusion and postthrombotic syndrome after immediate compression for deep vein thrombosis

Blood ◽  
2018 ◽  
Vol 132 (21) ◽  
pp. 2298-2304 ◽  
Author(s):  
Elham E. Amin ◽  
Ingrid M. Bistervels ◽  
Karina Meijer ◽  
Lidwine W. Tick ◽  
Saskia Middeldorp ◽  
...  
Keyword(s):  
Deep Vein Thrombosis ◽  
Compression Therapy ◽  
Postthrombotic Syndrome ◽  
Vein Thrombosis ◽  
Vein Occlusion ◽  
Absolute Reduction ◽  
Key Points ◽  
Deep Vein

Key Points Immediate compression therapy after DVT is associated with a 20% absolute reduction of RVO. The reduction of residual thrombosis is associated with an 8% absolute reduction of postthrombotic syndrome at 24 months.

Midterm Outcomes of Pharmacomechanical Thrombectomy in the Treatment of Lower Extremity Deep Vein Thrombosis With a Rotational Thrombectomy Device

2017 ◽  
Vol 51 (5) ◽  
pp. 301-306 ◽  
Author(s):  
Ahmet Yuksel ◽  
Oktay Tuydes
Keyword(s):  
Deep Vein Thrombosis ◽  
Lower Extremity ◽  
Postthrombotic Syndrome ◽  
Technical Success Rate ◽  
Vein Thrombosis ◽  
Rotational Thrombectomy ◽  
Thrombectomy Device ◽  
Deep Vein

Background: The purpose of this study was to assess the safety and efficacy with midterm outcomes of pharmacomechanical thrombectomy (PMT) performed by using a relatively new thrombectomy device in the treatment of lower extremity deep vein thrombosis (DVT). Methods: Between February 2014 and February 2016, a total of 46 patients with lower extremity DVT were treated with PMT by using Cleaner rotational thrombectomy system. Preprocedural, intraprocedural, postprocedural, and follow-up records of patients were collected and retrospectively analyzed. Results: Mean age of patients was 50.5 (14.8) years, and 58.7% of them were female. Technical success rate of procedure was 91.3%. Mean procedure time was 81.8 (40.3) minutes. Early clinical improvement was observed in all patients with successful treatment. No serious adverse event related to procedure and mortality was observed. Mean follow-up time was 16.0 (7.9) months. Reocclusion was observed in 7 (17.5%) patients during the follow-up period. Venous patency rates of patients at 1-, 3-, 6-, and 12-month follow-up visits were 95%, 92.5%, 89.7%, and 79.5%, respectively. Mild, moderate, and severe postthrombotic syndrome were observed in 8 (20%) patients, 4 (10%) patients, and 1 (2.5%) patient, respectively. Postthrombotic syndrome–free survival rate was 67.5%. Conclusion: Cleaner rotational thrombectomy system appears to be safe and effective in the treatment of lower extremity DVT. Further larger randomized studies are needed to determine the long-term outcomes of this treatment modality.

Clot busting in kids: less PTS?

Blood ◽  
2007 ◽  
Vol 110 (1) ◽  
pp. 4-5
Author(s):  
Leslie Raffini
Keyword(s):  
Deep Vein Thrombosis ◽  
High Risk ◽  
Lower Extremity ◽  
Thrombolytic Therapy ◽  
Retrospective Analysis ◽  
Pediatric Patients ◽  
Postthrombotic Syndrome ◽  
Mechanical Thrombolysis ◽  
Vein Thrombosis ◽  
Deep Vein

Goldenberg and colleagues' retrospective analysis of pediatric patients with high-risk, occlusive lower extremity deep vein thrombosis (DVT) suggests that thrombolytic therapy with tPA (with or without mechanical thrombolysis) may decrease the risk of postthrombotic syndrome (PTS).

scholarly journals Catheter-Directed Thrombolysis Versus Standard Anticoagulation for Acute Lower Extremity Deep Vein Thrombosis: A Meta-Analysis of Clinical Trials

2017 ◽  
Vol 24 (7) ◽  
pp. 1134-1143 ◽  
Author(s):  
Yongming Lu ◽  
Linyi Chen ◽  
Jinhui Chen ◽  
Tao Tang
Keyword(s):  
Deep Vein Thrombosis ◽  
Lower Extremity ◽  
Meta Analysis ◽  
Anticoagulation Therapy ◽  
Postthrombotic Syndrome ◽  
Bleeding Events ◽  
Vein Thrombosis ◽  
Catheter Directed Thrombolysis ◽  
Significant Difference ◽  
Deep Vein

Standard anticoagulant treatment alone for acute lower extremity deep vein thrombosis (DVT) is ineffective in eliminating thrombus from the deep venous system, with many patients developing postthrombotic syndrome (PTS). Because catheter-directed thrombolysis (CDT) can dissolve the clot, reducing the development of PTS in iliofemoral or femoropopliteal DVT. This meta-analysis compares CDT plus anticoagulation versus standard anticoagulation for acute iliofemoral or femoropopliteal DVT. Ten trials were included in the meta-analysis. Compared with anticoagulant alone, CDT was shown to significantly increase the percentage patency of the iliofemoral vein ( P < .00001; I2 = 44%) and reduce the risk of PTS ( P = .0002; I2 = 79%). In subgroup analysis of randomized controlled trials, CDT was not shown to prevent PTS ( P = .2; I2 = 59%). A reduced PTS risk was shown, however, in nonrandomized trials ( P < .00001; I2 = 47%). Meta-analysis showed that CDT can reduce severe PTS risk ( P = .002; I2 = 0%). However, CDT was not indicated to prevent mild PTS ( P = .91; I2 = 79%). A significant increase in bleeding events ( P < .00001; I2 = 33%) and pulmonary embolism (PE) ( P < .00001; I2 = 14%) were also demonstrated. However, for the CDT group, the duration of stay in the hospital was significantly prolonged compared to the anticoagulant group ( P < .00001; I2 = 0%). There was no significant difference in death ( P = .09; I2 = 0%) or recurrent venous thromboembolism events ( P = .52; I2 = 58%). This meta-analysis showed that CDT may improve patency of the iliofemoral vein or severe PTS compared with anticoagulation therapy alone, but measuring PTS risk remains controversial. However, CDT could increase the risk of bleeding events, PE events, and duration of hospital stay.

Postthrombotic syndrome following upper extremity deep vein thrombosis in children

Blood ◽  
2014 ◽  
Vol 124 (7) ◽  
pp. 1166-1173 ◽  
Author(s):  
Maria L. Avila ◽  
Lucy Duan ◽  
Amanda Cipolla ◽  
Ashley Kim ◽  
Walter H. A. Kahr ◽  
...  
Keyword(s):  
Deep Vein Thrombosis ◽  
Upper Extremity ◽  
Upper Limb ◽  
Postthrombotic Syndrome ◽  
Vein Thrombosis ◽  
Key Points ◽  
Deep Vein

Key Points Upper limb PTS in children depends on DVT pathogenesis (primary vs secondary) and on the age of the patient (neonates vs non-neonates). DVT pathogenesis and thrombus resolution are independent predictors of upper limb PTS in children.

scholarly journals Lower extremity deep vein thrombosis after heavy exertion

2013 ◽  
Vol 2013 (nov18 1) ◽  
pp. bcr2013201488-bcr2013201488
Author(s):  
S. Tak ◽  
S. Tak
Keyword(s):  
Deep Vein Thrombosis ◽  
Lower Extremity ◽  
Vein Thrombosis ◽  
Deep Vein

scholarly journals Recurrence of Upper Extremity Deep Vein Thrombosis Secondary to COVID-19

Viruses ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 878
Author(s):  
Yesha H. Parekh ◽  
Nicole J. Altomare ◽  
Erin P. McDonnell ◽  
Martin J. Blaser ◽  
Payal D. Parikh
Keyword(s):  
Deep Vein Thrombosis ◽  
Lower Extremity ◽  
Upper Extremity ◽  
Thromboembolic Events ◽  
Vein Thrombosis ◽  
Venous Thromboembolic Events ◽  
Venous Thromboembolic ◽  
Deep Vein

Infection with SARS-CoV-2 leading to COVID-19 induces hyperinflammatory and hypercoagulable states, resulting in arterial and venous thromboembolic events. Deep vein thrombosis (DVT) has been well reported in COVID-19 patients. While most DVTs occur in a lower extremity, involvement of the upper extremity is uncommon. In this report, we describe the first reported patient with an upper extremity DVT recurrence secondary to COVID-19 infection.

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