Speed bumps on the road to a chemotherapy-free world for lymphoma patients

AbstractWith the increasing number of targeted agents for the treatment of patients with lymphoid malignancies comes the promise of safe and effective chemotherapy-free treatment strategies. A number of single agents, such as ibrutinib and idelalisib, have demonstrated impressive efficacy with a favorable toxicity profile. The observations that most responses are, however, partial and treatment duration is indefinite have stimulated interest in combinations of these agents with chemotherapy as well as with each other. Despite the promise of this approach, several recent trials of combinations of agents have been terminated as the result of life-threatening and fatal complications. Such outcomes have generated a cautionary note of the potential for unforeseen adverse effects that challenge drug development and mitigate against the empiric combination of such drugs outside of a clinical trial setting.

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Diabetes mellitus and driving a motor vehicle

Diabetes Mellitus ◽

10.14341/dm8013 ◽

2016 ◽

Vol 19 (5) ◽

pp. 414-420

Author(s):

Mariya Nikolaevna Dunicheva ◽

Olga Yuryevna Martyanova ◽

Evgeniya Mikhailovna Patrakeeva ◽

Alsu Gafurovna Zalevskaya

Keyword(s):

Diabetes Mellitus ◽

Motor Vehicle ◽

The Road ◽

Glucose Levels ◽

Driving Impairment ◽

Complex Process ◽

Driver's License ◽

Life Threatening ◽

On The Road ◽

Meta Analyses

Diabetes mellitus is a chronic disease that not only affects the lives of patients but also influences their social interactions, including driving. Driving a motor vehicle is a complex process, requiring good visuospatial function, rapid information processing, vigilance and high decision-making skills. Potential causes of driving impairment associated with diabetes include hypoglycemia and its effects on unawareness, retinopathy, neuropathy and ischemic heart disease. The effects of hypoglycemia can lead to dangerous and life-threatening events for both the driver and others on the road. Research data confirm that impairments from hypoglycemia affect driving performance. Many trials and meta-analyses have revealed that not all drivers follow precautions such as measuring blood glucose levels before driving; therefore, this problem remains quite relevant. In Russian Federation, the process of a person with diabetes obtaining a driver’s license is not uniformly regulated, even though this issue is related to road safety.

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Evaluation of awareness level of Taliqan residents about the health hazard of environmental pollution

International Journal of Innovative Research and Scientific Studies ◽

10.53894/ijirss.v3i1.27 ◽

2020 ◽

Vol 3 (1) ◽

pp. 10-14

Author(s):

Nazar Mohammad Wahaj ◽

Mohammad Hassan Abidi

Keyword(s):

Environmental Pollution ◽

Health Hazard ◽

Health Hazards ◽

The Road ◽

Waste Storage ◽

Life Threatening ◽

The Media ◽

On The Road ◽

The City ◽

Awareness Level

Protecting the environment is one of the most important responsibilities for every human being to keep it clean and protected. The pollutant and contaminated environment will cause many life-threatening diseases. It is well known that humans’ activities are the main causes of environmental pollution, therefore this research is aimed to evaluate the awareness level of Taliqan residents about the health hazards and environmental pollutions. The method used in this study was descriptive analytics and the data was collected through the questionnaires distributed to the townspeople and their responses were recorded. The results of this study showed that among 540 participants, 45.1% have fully awareness about the type of pollution and its health hazards, 25.74% have good knowledge, 14% have medal awareness, 11.85% have low awareness, 3.14% did not have any unaware. Also, none of the participants did not report daily activities of the municipality regarding management and cleanup of the city, while 1.85% reported the weekly activities, 20% monthly activities, 49.62% confirmed the non- program activities, and 19.44% were unaware of the city’s cleanup process by municipal authorities’ responsible persons. This study concludes that poor management of municipal officials, lack of waste containers on the road sides and amusement parks are the main reasons behind the waste storage and aggregation of rubbish in every corner of the city. In addition, lack of effective environmental education programs through the media has made the culture of urbanization and environmental protection less institutionalized among citizens.

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