scholarly journals FEMORAL BONE MARROW BIOPSY IN THE ALBINO RAT

Blood ◽  
1948 ◽  
Vol 3 (3) ◽  
pp. 292-294 ◽  
Author(s):  
D. G. CAMERON ◽  
G. M. WATSON

Abstract A technic for repeated femoral bone marrow biopsy in the rat is detailed. Differential counts confirmed the distribution of the cellular elements as described by other authors.

Bone Reports ◽  
2021 ◽  
Vol 14 ◽  
pp. 100844
Author(s):  
Drenka Trivanovic ◽  
Janek Hader ◽  
Maximilian Leucht ◽  
Theresa Kreuzahler ◽  
Bianca Schlierf ◽  
...  

Blood ◽  
1964 ◽  
Vol 23 (1) ◽  
pp. 87-98 ◽  
Author(s):  
JAMES W. FISHER ◽  
B. L. ROH ◽  
CHARLES COUCH ◽  
W. O. NIGHTINGALE

Abstract A technic has been developed for studying the femoral bone marrow of the dog by perfusing the isolated hind limb. With the use of this method, bone marrows were perfused for 4-6 hours with donor dog blood alone and blood containing sheep erythropoietin, cobalt, growth hormone, hydrocortisone, 3,5,3'-triiodothyronine or testosterone. Significant increases were seen in nucleated erythroid cell counts within femoral marrows perfused with blood containing sheep erythropoietin and cobalt. A slight increase was also noted in the bone marrows from limbs in which growth hormone was added to the perfusion system. It may be concluded from these experiments that erythropoietin, cobalt and growth hormone are capable of stimulating erythroid hyperplasia in the bone marrow directly.


Blood ◽  
1965 ◽  
Vol 26 (3) ◽  
pp. 309-316 ◽  
Author(s):  
EVELYN E. VARSA ◽  
EUGENE S. HANDLER ◽  
ALBERT S. GORDON

Abstract Procedures of bone marrow quantitation have been applied to the study of the pathogenesis of a leukemia in rats. Mature Long-Evans rats developed an acute form of the Shay Chloroleukemia after intravenous administration of leukemic cells. Assessment of total nucleated cell numbers (normal and leukemic) per mg. of femoral bone marrow was made during the course of the pathogenesis (20 days). Reductions in the numbers of normal marrow elements were observed prior to significant increases in chloroleukemic cells. A progressive decrease in total marrow cellularity was noted in all subsequent stages. In animals surviving 17-20 days, the total number of hemic cells in the femoral marrow was found to be approximately 40 per cent of that seen in normal animals. The leukemia developed more rapidly in young than in adult animals. Using total and differential bone marrow cellularity as a criterion for the stage of pathogenesis, standardized leukemic rats can be prepared for experimentation.


1999 ◽  
Vol 67 (7) ◽  
pp. S176
Author(s):  
H Suzuki ◽  
N Patel ◽  
A J DelRossi ◽  
J H Cilley ◽  
M Matthews ◽  
...  

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