scholarly journals Tritium retention in femoral bone marrow and spleens of mice receiving single intravenous injections of tritiated water and tritiated thymidine.

1987 ◽  
Vol 28 (3) ◽  
pp. 204-212
Author(s):  
HISAMASA JOSHIMA ◽  
SATORU MATSUSHITA ◽  
KUMIKO FUKUTSU ◽  
MASATOSHI KASHIMA
Bone Reports ◽  
2021 ◽  
Vol 14 ◽  
pp. 100844
Author(s):  
Drenka Trivanovic ◽  
Janek Hader ◽  
Maximilian Leucht ◽  
Theresa Kreuzahler ◽  
Bianca Schlierf ◽  
...  

Blood ◽  
1948 ◽  
Vol 3 (3) ◽  
pp. 292-294 ◽  
Author(s):  
D. G. CAMERON ◽  
G. M. WATSON

Abstract A technic for repeated femoral bone marrow biopsy in the rat is detailed. Differential counts confirmed the distribution of the cellular elements as described by other authors.


Blood ◽  
1964 ◽  
Vol 23 (1) ◽  
pp. 87-98 ◽  
Author(s):  
JAMES W. FISHER ◽  
B. L. ROH ◽  
CHARLES COUCH ◽  
W. O. NIGHTINGALE

Abstract A technic has been developed for studying the femoral bone marrow of the dog by perfusing the isolated hind limb. With the use of this method, bone marrows were perfused for 4-6 hours with donor dog blood alone and blood containing sheep erythropoietin, cobalt, growth hormone, hydrocortisone, 3,5,3'-triiodothyronine or testosterone. Significant increases were seen in nucleated erythroid cell counts within femoral marrows perfused with blood containing sheep erythropoietin and cobalt. A slight increase was also noted in the bone marrows from limbs in which growth hormone was added to the perfusion system. It may be concluded from these experiments that erythropoietin, cobalt and growth hormone are capable of stimulating erythroid hyperplasia in the bone marrow directly.


Blood ◽  
1965 ◽  
Vol 26 (3) ◽  
pp. 309-316 ◽  
Author(s):  
EVELYN E. VARSA ◽  
EUGENE S. HANDLER ◽  
ALBERT S. GORDON

Abstract Procedures of bone marrow quantitation have been applied to the study of the pathogenesis of a leukemia in rats. Mature Long-Evans rats developed an acute form of the Shay Chloroleukemia after intravenous administration of leukemic cells. Assessment of total nucleated cell numbers (normal and leukemic) per mg. of femoral bone marrow was made during the course of the pathogenesis (20 days). Reductions in the numbers of normal marrow elements were observed prior to significant increases in chloroleukemic cells. A progressive decrease in total marrow cellularity was noted in all subsequent stages. In animals surviving 17-20 days, the total number of hemic cells in the femoral marrow was found to be approximately 40 per cent of that seen in normal animals. The leukemia developed more rapidly in young than in adult animals. Using total and differential bone marrow cellularity as a criterion for the stage of pathogenesis, standardized leukemic rats can be prepared for experimentation.


1999 ◽  
Vol 67 (7) ◽  
pp. S176
Author(s):  
H Suzuki ◽  
N Patel ◽  
A J DelRossi ◽  
J H Cilley ◽  
M Matthews ◽  
...  

1994 ◽  
Vol 3 (1) ◽  
pp. 23-25 ◽  
Author(s):  
Y. Denizot ◽  
V. Praloran

Haematopoietic organs of rats were examined for the presence of platelet-activating factor (PAF) and acetylhydrolase before and after treatment with 5-fluoro-uracil (5-FU) (200 mg/kg) a chemotherapeutic compound with apoptotic effects. PAF was reported in thymus, spleen and femoral bone marrow of rats with or without 5-FU. Although acetylhydrolase activity in organs was not affected by 5-FU treatment, elevated levels of PAF were observed in thymus and spleen. For the first time PAF is reported in haematopoietic organs of rats, strengtheningin vitrodata suggesting its role in the apoptotic processes in thymus, in the modulation of the immune response, and in the regulation of haematopoiesis.


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