scholarly journals Oxymetholone treatment for sickle cell anemia

Blood ◽  
1975 ◽  
Vol 45 (6) ◽  
pp. 769-777 ◽  
Author(s):  
R Alexanian ◽  
J Nadell
Keyword(s):  
Sickle Cell ◽  
Sickle Cell Anemia ◽  
Cell Mass ◽  
Iron Level ◽  
Red Cell ◽  
Bilirubin Concentration ◽  
Serum Iron Level ◽  
Control Value ◽  
Red Cell Mass ◽  
Androgenic Hormone

Abstract Seven patients with sickle cell anemia were treated with oxymetholone for at least 2 mo. Markedly increased basal rates of hemolysis and erythropoiesis were confirmed. The urinary erythropoietin excretion was either normal or lower than expected for the red cell mass, and an expanded blood volume was due primarily to an increased plasma volume. After androgen therapy, six patients demonstrated more than a fivefold increase in urinary erythropoietin, with an increase in red cell mass ranging from 17%-75% above the control value. All showed a decline in serum iron level to the 25–75 mug/100 ml range within 4 wk after the start of therapy. Less marked changes followed lower oxymetholone doses. Reversible hepatic toxicity, with a serum bilirubin concentration exceeding 50 mg/100 ml, occurred in one patient. Androgenic hormone therapy may be useful for selected adult patients with sickle cell disease when severe anemia contributes to disease morbidity.

scholarly journals Oxymetholone treatment for sickle cell anemia

Blood ◽  
1975 ◽  
Vol 45 (6) ◽  
pp. 769-777
Author(s):  
R Alexanian ◽  
J Nadell
Keyword(s):  
Sickle Cell ◽  
Sickle Cell Anemia ◽  
Cell Mass ◽  
Iron Level ◽  
Red Cell ◽  
Bilirubin Concentration ◽  
Serum Iron Level ◽  
Control Value ◽  
Red Cell Mass ◽  
Androgenic Hormone

Seven patients with sickle cell anemia were treated with oxymetholone for at least 2 mo. Markedly increased basal rates of hemolysis and erythropoiesis were confirmed. The urinary erythropoietin excretion was either normal or lower than expected for the red cell mass, and an expanded blood volume was due primarily to an increased plasma volume. After androgen therapy, six patients demonstrated more than a fivefold increase in urinary erythropoietin, with an increase in red cell mass ranging from 17%-75% above the control value. All showed a decline in serum iron level to the 25–75 mug/100 ml range within 4 wk after the start of therapy. Less marked changes followed lower oxymetholone doses. Reversible hepatic toxicity, with a serum bilirubin concentration exceeding 50 mg/100 ml, occurred in one patient. Androgenic hormone therapy may be useful for selected adult patients with sickle cell disease when severe anemia contributes to disease morbidity.

Does high serum iron level induce low bone mass in sickle cell anemia ?

BioMetals ◽  
2010 ◽  
Vol 24 (1) ◽  
pp. 19-22 ◽  
Author(s):  
Mir Sadat-Ali ◽  
Osama Sultan ◽  
Haifa Al-Turki ◽  
Abdulmohsen AlElq
Keyword(s):  
Bone Mass ◽  
Sickle Cell ◽  
Sickle Cell Anemia ◽  
Serum Iron ◽  
High Serum ◽  
Iron Level ◽  
Low Bone Mass ◽  
Serum Iron Level

Tolerance of recently hemorrhaged rats to secondary trauma

1959 ◽  
Vol 197 (4) ◽  
pp. 786-790 ◽  
Author(s):  
Morton D. Pareira ◽  
Kenneth D. Serkes ◽  
Stanley Lang
Keyword(s):  
Secondary Trauma ◽  
Cell Mass ◽  
Sodium Pentobarbital ◽  
Red Cell ◽  
Circulating Blood Volume ◽  
Sleeping Time ◽  
Control Value ◽  
Red Cell Mass ◽  
Dose Levels ◽  
Circulating Volume

The ability of rats to withstand a second hemorrhage 48 hours after the loss of one-half of the circulating volume was diminished from that of the normal control in terms of the absolute amounts which could be withdrawn. In terms of the relative amounts (ml whole blood withdrawn/100 ml total circulating blood volume) which could be withdrawn, the previously hemorrhaged rats showed a tolerance at least that of the controls. The red cell mass at this time was 67% of the control value. No difference in ability to tolerate bilateral hind leg tourniquet trauma was demonstrated between control and hemorrhaged animals at each of two different lengths of tourniquet application (3 1/2 and 4 hr.). Sleeping time determinations at two dose levels demonstrated no difference in tolerance to intraperitoneal sodium pentobarbital between normal and previously bled rats. It is postulated that decreased tolerance to trauma when occurring in association with diminished circulating volume is a function of the type of volume demand made by the trauma and the size of the specific volume compartment available.

The orientation of sickle hemoglobin fibers within fascicles

1988 ◽  
Vol 46 ◽  
pp. 400-401
Author(s):  
Christopher A. Miller ◽  
Bridget Carragher ◽  
William A. McDade ◽  
Robert Josephs
Keyword(s):  
Sickle Cell ◽  
Sickle Cell Anemia ◽  
Relative Orientation ◽  
Unit Cell ◽  
Red Cell ◽  
High Ph ◽  
Sickle Hemoglobin ◽  
Polar Crystal ◽  
Helical Configuration

Highly ordered bundles of deoxyhemoglobin S (HbS) fibers, termed fascicles, are intermediates in the high pH crystallization pathway of HbS. These fibers consist of 7 Wishner-Love double strands in a helical configuration. Since each double strand has a polarity, the odd number of double strands in the fiber imparts a net polarity to the structure. HbS crystals have a unit cell containing two double strands, one of each polarity, resulting in a net polarity of zero. Therefore a rearrangement of the double strands must occur to form a non-polar crystal from the polar fibers. To determine the role of fascicles as an intermediate in the crystallization pathway it is important to understand the relative orientation of fibers within fascicles. Furthermore, an understanding of fascicle structure may have implications for the design of potential sickling inhibitors, since it is bundles of fibers which cause the red cell distortion responsible for the vaso-occlusive complications characteristic of sickle cell anemia.

Troglitazone has no effect on red cell mass or other erythropoietic parameters

1999 ◽  
Vol 55 (2) ◽  
pp. 101-104 ◽  
Author(s):  
M. M. R. Young ◽  
L. Squassante ◽  
J. Wemer ◽  
S. P. van Marle ◽  
P. Dogterom ◽  
...  
Keyword(s):  
Cell Mass ◽  
Red Cell ◽  
Red Cell Mass

Benign Sickle Cell Anemia in Israeli-Arabs with High Red Cell 2,3 Diphosphoglycerate

1978 ◽  
Vol 59 (4) ◽  
pp. 237-245 ◽  
Author(s):  
Eugene F. Roth ◽  
Eliezer H. Rachmilewitz ◽  
Alicia Schifter ◽  
Ronald L. Nagel
Keyword(s):  
Sickle Cell ◽  
Sickle Cell Anemia ◽  
Red Cell ◽  
Israeli Arabs

Should Whole-Body Red Cell Mass Be Measured or Calculated?

2000 ◽  
Vol 26 (1) ◽  
pp. 25-31 ◽  
Author(s):  
Ingrid Balga ◽  
Max Solenthaler ◽  
Miha Furlan
Keyword(s):  
Cell Mass ◽  
Whole Body ◽  
Red Cell ◽  
Red Cell Mass

Analysis of Red Cell Mass and Plasma Volume in Patients With Polycythemia

2005 ◽  
Vol 129 (1) ◽  
pp. 89-91 ◽  
Author(s):  
Mordechai Lorberboym ◽  
Naomi Rahimi-Levene ◽  
Helena Lipszyc ◽  
Chun K. Kim
Keyword(s):  
Body Weight ◽  
Plasma Volume ◽  
Cell Mass ◽  
Mean Value ◽  
Whole Body ◽  
Red Cell ◽  
Volume Data ◽  
Red Cell Mass ◽  
The Mean ◽  
Iodine 125

Abstract Context.—Polycythemia describes an increased proportion of red blood cells in the peripheral blood. In absolute polycythemia, there is increased red cell mass (RCM) with normal plasma volume, in contrast with apparent polycythemia, in which there is increased or normal RCM and decreased plasma volume. In order to deliver the appropriate treatment it is necessary to differentiate between the two. Objective.—A retrospective analysis of RCM and plasma volume data are presented, with special attention to different methods of RCM interpretation. Design.—The measurements of RCM and plasma volume in 64 patients were compared with the venous and whole-body packed cell volume, and the incidence of absolute and apparent polycythemia was determined for increasing hematocrit levels. Measurements of RCM and plasma volume were performed using chromium 51–labeled red cells and iodine 125–labeled albumin, respectively. The measured RCM of each patient was expressed as a percentage of the mean expected RCM and was also defined as being within or outside the range of 2 SD of the mean. The results were also expressed in the traditional manner of mL/kg body weight. Results.—Twenty-one patients (13 women and 8 men) had absolute polycythemia. None of them had an increased plasma volume beyond 2 SD of the mean. When expressed according to the criteria of mL/kg body weight, 17 of the 21 patients had abnormally increased RCM, but 4 patients (19%) had a normal RCM value. Twenty-eight patients had apparent polycythemia. The remaining 15 patients had normal RCM and plasma volume. Conclusions.—The measurement of RCM and plasma volume is a simple and necessary procedure in the evaluation of polycythemia. In obese patients, the expression of RCM in mL/kg body weight lacks precision, considering that adipose tissue is hypovascular. The results of RCM are best described as being within or beyond 2 SD of the mean value.

Failure of prolonged exercise training to increase red cell mass in humans

1996 ◽  
Vol 270 (1) ◽  
pp. H121-H126 ◽  
Author(s):  
J. K. Shoemaker ◽  
H. J. Green ◽  
J. Coates ◽  
M. Ali ◽  
S. Grant
Keyword(s):  
Exercise Training ◽  
Prolonged Exercise ◽  
Cell Mass ◽  
Hemoglobin Concentration ◽  
Red Cell ◽  
Total Blood ◽  
Mean Cell Volume ◽  
Red Cell Mass ◽  
Mean Cell Hemoglobin

The purpose of this study was to investigate the time-dependent effects of long-term prolonged exercise training on vascular volumes and hematological status. Training using seven untrained males [age 21.1 +/- 1.4 (SE) yr] initially consisted of cycling at 68% of peak aerobic power (VO2peak) for 2 h/day, 4-5 days/wk, for 11 wk. Absolute training intensity was increased every 3 wk. Red cell mass (RCM), obtained using 51Cr, was unchanged (P > 0.05) with training (2,142 +/- 95, 2,168 +/- 86, 2,003 +/- 112, and 2,080 +/- 116 ml at 0, 3, 6, and 11 wk, respectively) as were serum erythropoietin levels (17.1 +/- 4.3, 13.9 +/- 3.5, and 17.0 +/- 2.0 U/l at 0, 6, and 11 wk, respectively). Plasma volume measured with 125I-labeled albumin and total blood volume (TBV) were also not significantly altered. The increase in mean cell volume that occurred with training (89.7 +/- 0.95 vs. 91.0 +/- 1.0 fl, 0 vs. 6 wk, P < 0.05) was not accompanied by changes in either mean cell hemoglobin or mean cell hemoglobin concentration. Serum ferritin was reduced 73% with training (67.4 +/- 13 to 17.9 +/- 1 microgram/l, 0 vs. 11 wk, P < 0.05). Total hemoglobin (HbTot) calculated as the product of hemoglobin concentration and TBV was unaltered (P > 0.05) at both 6 and 11 wk of training. The 15% increase in VO2peak (3.39 +/- 0.16 to 3.87 +/- 0.14 l/min, 0 vs. 11 wk, P < 0.05) with training occurred despite a failure of training to change TBV, RCM, or HbTot.

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