scholarly journals Acute monoblastic leukemia in infancy and early childhood: successful treatment with an epipodophyllotoxin

Blood ◽  
1984 ◽  
Vol 64 (4) ◽  
pp. 875-882 ◽  
Author(s):  
LF Odom ◽  
EM Gordon
Keyword(s):  
Early Childhood ◽  
Single Agent ◽  
The Other ◽  
Monocytic Leukemia ◽  
Systemic Involvement ◽  
The Third ◽  
Acute Monoblastic Leukemia ◽  
Leukemia Cutis ◽  
Infancy And Early Childhood ◽  
Infants And Young Children

Four of five infants and young children with acute monoblastic leukemia, a disease that heretofore has been highly refractory to therapy, were successfully treated with sequential infusions of a podophyllin derivative employed as a single agent over a protracted period of time. In three of the five children, monocytic leukemia cutis was present at birth. Treatment was begun in two of them when the disease had progressed to systemic involvement at a few months of age, and in the third when disease was still localized. The other two children were 11 and 18 months of age at initial presentation with widespread disease. Four children are off therapy 11 months, 26 months, 5 years, and 6 years, respectively.

scholarly journals Acute monoblastic leukemia in infancy and early childhood: successful treatment with an epipodophyllotoxin

Blood ◽  
1984 ◽  
Vol 64 (4) ◽  
pp. 875-882 ◽  
Author(s):  
LF Odom ◽  
EM Gordon
Keyword(s):  
Early Childhood ◽  
Single Agent ◽  
The Other ◽  
Monocytic Leukemia ◽  
Systemic Involvement ◽  
The Third ◽  
Acute Monoblastic Leukemia ◽  
Leukemia Cutis ◽  
Infancy And Early Childhood ◽  
Infants And Young Children

Abstract Four of five infants and young children with acute monoblastic leukemia, a disease that heretofore has been highly refractory to therapy, were successfully treated with sequential infusions of a podophyllin derivative employed as a single agent over a protracted period of time. In three of the five children, monocytic leukemia cutis was present at birth. Treatment was begun in two of them when the disease had progressed to systemic involvement at a few months of age, and in the third when disease was still localized. The other two children were 11 and 18 months of age at initial presentation with widespread disease. Four children are off therapy 11 months, 26 months, 5 years, and 6 years, respectively.

scholarly journals Not Quite as Grown-Up as We Like to Think

2005 ◽  
Vol 16 (4) ◽  
pp. 291-297 ◽  
Author(s):  
Adele Diamond ◽  
Natasha Kirkham
Keyword(s):  
Early Childhood ◽  
Dimensional Change ◽  
Dependent Measure ◽  
The Other ◽  
Card Sort ◽  
Sensitive Measure ◽  
Infancy And Early Childhood ◽  
Dimensional Change Card Sort

Greater continuity in cognition between children and adults may exist than is usually appreciated. It was thought that after 3 to 4 years of age, the problem in switching on the dimensional-change card-sort task disappears. We show here, however, that if speed is used as the dependent measure, the effect of the first dimension is evident even in adults. Adults, like preschoolers, show difficulty in switching from a block of sorting by color or shape to a block of sorting by the other dimension. Notably, performance throughout the session was affected by the first dimension by which stimuli were sorted. We hypothesize that perhaps adults never fully outgrow any of the cognitive and perceptual biases of infancy and early childhood. Other examples of such biases that appear to still be present in adults are discussed. Conversely, the assumption that the optimal dependent measure for adults is the most sensitive measure for children is questioned.

Multimodal Music in Infancy and Early Childhood

2018 ◽  
pp. 382-398
Author(s):  
Sandra E. Trehub
Keyword(s):  
Early Childhood ◽  
Young Children ◽  
Self Regulation ◽  
Early Years ◽  
Temporal Patterning ◽  
Creative Play ◽  
Early School ◽  
Infancy And Early Childhood ◽  
Infants And Young Children ◽  
Musical Forms

Music in the early years is best understood as creative play with sound and body. Infants are highly responsive observers of mothers’ multimodal singing, which consists of expressive vocalizations in conjunction with facial and bodily gestures. Infants derive pleasure and solace from music, and they exhibit sensitivity to its pitch and temporal patterning. As toddlers, they engage in rudimentary singing and dancing, which ultimately become tools for emotional self-regulation. Preschoolers exhibit increasing sensitivity to culture-specific aspects of music. They sing as they play, producing conventional as well as invented songs and aligning their vocal patterns with their movements. By the early school years, children exhibit considerable understanding of musical forms and functions. Their melodic and rhythmic skills are more readily evident on the playground than in the classroom. Although music and movement are linked for adults, they are inseparable for infants and young children.

The Efficacy of Several New Handwashing Agents for Removing Non-Transient Bacterial Flora from Hands

1986 ◽  
Vol 7 (5) ◽  
pp. 268-272 ◽  
Author(s):  
Allan J. Morrison ◽  
Jean Gratz ◽  
Ignacio Cabezudo ◽  
Richard P. Wenzel
Keyword(s):  
Contact Time ◽  
Bacterial Flora ◽  
Single Agent ◽  
Chlorhexidine Gluconate ◽  
The Other ◽  
Log10 Reduction ◽  
Bacterial Reduction ◽  
Effective Agent ◽  
The Third ◽  
Usage Patterns

AbstractForty subjects participated in a study of four handwashing agents evaluated for their efficacy in removing non-transient bacteria: 70% isopropanol, 0.05% stabilized iodine, 4% chlorhexidine gluconate, and 1% para-chloro-meta-xylenol. Each subject performed a non-medicated handwash to remove transient flora. Afterwards, three consecutive experimental handwashes were performed using a 10-second contact time, and a fourth handwash employed a 1-minute contact time. Quantitative post-handwash cultures were obtained using the sterile bag technique incorporating an effective agent neutralizer. Significant mean log10 reductions were documented for chlorhexidine gluconate, but only after the third (P=.05) and fourth (p=.004) handwash; however, the total log10 reduction was less than 1.0 for any single agent.Subsequently, three evaporative handwash agents, including 70% isopropanol, 0.5% chlorhexidine in 70% isopropanol, and a 60% isopropanol formulation containing evaporative retardants, were tested in 14 subjects. Contact time was prolonged to the point of evaporation prior to culturing. Four consecutive post-handwash cultures were obtained after performing a baseline pre-handwash culture. When compared with the other two evaporative agents, the 60% isopropanol formulation demonstrated significant mean log10 reductions for each handwash (p ≤ .03), with a total log10 reduction of 2.9 over all four handwashes (p=.0001). The brief contact time incorporated in our handwashing technique reflects clinical usage patterns. The marked bacterial reduction demonstrated by the 60% isopropanol formulation warrants further study.

Efficacy of some insecticide modules against major insect pests and spider population of rice, Oryza sativa L.

ENTOMON ◽  
2018 ◽  
Vol 43 (4) ◽  
pp. 257-262
Author(s):  
Atanu Seni ◽  
Bhimasen Naik
Keyword(s):  
Oryza Sativa ◽  
Grain Yield ◽  
Untreated Control ◽  
Insect Pests ◽  
Oryza Sativa L ◽  
Gall Midge ◽  
Stem Borer ◽  
The Other ◽  
The Third ◽  
Treated Plot

Experiments were carried out to assess some insecticide modules against major insect pests of rice. Each module consists of a basal application of carbofuran 3G @ 1 kg a.i ha-1 at 20 DAT and Rynaxypyr 20 SC @ 30 g a.i ha-1 at 45 DAT except untreated control. All modules differ with each other only in third treatment which was applied in 65 DAT. The third treatment includes: Imidacloprid 17.8 SL @ 27 g a.i ha-1, Pymetrozine 50 WG @ 150 g a.i ha-1, Triflumezopyrim 106 SC @ 27 g a.i ha-1, Buprofezin 25 SC @ 250 g a.i ha-1; Glamore (Imidacloprid 40+Ethiprole 40% w/w) 80 WG @ 100 g a.i. ha-1, Thiacloprid 24 SC @ 60 g a.i ha-1, Azadirachtin 0.03 EC @ 8 g a.i ha-1, Dinotefuran 20 SG@ 40 g a.i ha-1 and untreated control. All the treated plots recorded significantly lower percent of dead heart, white ear- head caused by stem borer and silver shoot caused by gall midge. Module with Pymetrozine 50 WG @ 150 g a.i ha-1 treated plot recorded significantly higher per cent reduction of plant hoppers (>80% over untreated control) and produced higher grain yield (50.75 qha-1) than the other modules. Among the different treated modules the maximum number of spiders was found in Azadirachtin 0.03 EC @ 8 g a.i ha-1 treated module plot followed by other treatments.

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