Production of leukemic blast growth factor by a human bladder carcinoma cell line
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Abstract Circulating blast cells from the peripheral blood of acute myeloblastic leukemia patients include a subpopulation capable of colony formation in the presence of phytohemagglutinin-stimulated leukocyte-conditioned medium (PHA-LCM). We describe the complete replacement in the blast assay of PHA-LCM by conditioned medium from a human bladder carcinoma cell line, HTB9. Both conditioned media contain a stimulator of blast cell growth that elutes as a single peak from a Sephadex G100 column with an apparent molecular weight of 30,000. It is shown that this leukemic blast growth factor is distinct from erythroid-potentiating activity (EPA) and possibly granulocyte macrophage colony-stimulating factor.
1990 ◽
Vol 190
(1)
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pp. 229-238
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1987 ◽
Vol 5
(6)
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pp. 504-510
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1994 ◽
Vol 32
(1)
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pp. 63-72
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1993 ◽
Vol 155
(2)
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pp. 368-375
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1986 ◽
Vol 83
(8)
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pp. 2478-2482
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