Frequent c-myc oncogene activation and infrequent presence of Epstein- Barr virus genome in AIDS-associated lymphoma

Sixteen cases of histologic intermediate-grade and high-grade AIDS- associated non-Hodgkin's lymphoma (NHL) were studied for the presence and patterns of c-myc gene and bcl-2 locus rearrangements. The presence of Epstein-Barr virus (EBV) sequences and proteins and HTLV-I sequences were also investigated. c-myc gene rearrangements analogous to those observed in sporadic Burkitt lymphomas were detected in 12 of 16 cases. Six of 16 cases had detectable EBV sequences and proteins. None of the cases displayed bcl-2 rearrangements or contained HTLV-I sequences. These data suggest a frequent role for c-myc activation in the pathogenesis of AIDS-associated NHL, independent of histologic type. Conversely, EBV does not appear to be directly involved in lymphomagenesis in the majority of AIDS-associated NHLs.

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Frequent c-myc oncogene activation and infrequent presence of Epstein- Barr virus genome in AIDS-associated lymphoma

Blood ◽

10.1182/blood.v72.2.667.667 ◽

1988 ◽

Vol 72 (2) ◽

pp. 667-671 ◽

Cited By ~ 200

Author(s):

M Subar ◽

A Neri ◽

G Inghirami ◽

DM Knowles ◽

R Dalla-Favera

Keyword(s):

Epstein Barr Virus ◽

Virus Genome ◽

Gene Rearrangements ◽

High Grade ◽

Histologic Type ◽

Myc Oncogene ◽

Barr Virus ◽

Oncogene Activation ◽

Myc Gene ◽

Epstein Barr

Abstract Sixteen cases of histologic intermediate-grade and high-grade AIDS- associated non-Hodgkin's lymphoma (NHL) were studied for the presence and patterns of c-myc gene and bcl-2 locus rearrangements. The presence of Epstein-Barr virus (EBV) sequences and proteins and HTLV-I sequences were also investigated. c-myc gene rearrangements analogous to those observed in sporadic Burkitt lymphomas were detected in 12 of 16 cases. Six of 16 cases had detectable EBV sequences and proteins. None of the cases displayed bcl-2 rearrangements or contained HTLV-I sequences. These data suggest a frequent role for c-myc activation in the pathogenesis of AIDS-associated NHL, independent of histologic type. Conversely, EBV does not appear to be directly involved in lymphomagenesis in the majority of AIDS-associated NHLs.

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Epstein-Barr Virus Versus Novel Coronavirus-Induced Hemophagocytic Lymphohistocytosis: The Uncharted Waters

Journal of Investigative Medicine High Impact Case Reports ◽

10.1177/2324709620950107 ◽

2020 ◽

Vol 8 ◽

pp. 232470962095010 ◽

Cited By ~ 1

Author(s):

Rawan Amir ◽

Asim Kichloo ◽

Jagmeet Singh ◽

Ravinder Bhanot ◽

Michael Aljadah ◽

...

Keyword(s):

Bacterial Infections ◽

Epstein Barr Virus ◽

Genetic Mutations ◽

High Grade ◽

The Novel ◽

Barr Virus ◽

First Case ◽

Epstein Barr ◽

Virus Versus ◽

Novel Coronavirus

Hemophagocytic lymphohistocytosis (HLH) is a hyperinflammatory syndrome characterized by fever, hepatosplenomegaly, and pancytopenia. It may be associated with genetic mutations or viral/bacterial infections, most commonly Epstein-Barr virus (EBV) and cytomegalovirus. As for the novel coronavirus, severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), also known as COVID-19 (coronavirus disease-2019), the cytokine storm it triggers can theoretically lead to syndromes similar to HLH. In this article, we report a case of a 28-year-old female who presented with high-grade fevers, found to have both SARS-CoV-2 and EBV infections, and eventually began to show signs of early HLH. To our knowledge, this is the first case reported in literature that raises the possibility of SARS-CoV-2–related HLH development.

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HIGH FREQUENCY OF EPSTEIN-BARR VIRUS GENOME IN HIV-POSITIVE PATIENTS WITH HODGKIN'S DISEASE

The Lancet ◽

10.1016/s0140-6736(89)90171-2 ◽

1989 ◽

Vol 333 (8652) ◽

pp. 1458 ◽

Cited By ~ 39

Author(s):

Stefania Uccini ◽

Francesca Monardo ◽

LuigiP. Ruco ◽

CarloD. Baroni ◽

Alberto Faggioni ◽

...

Keyword(s):

Hodgkin's Disease ◽

High Frequency ◽

Epstein Barr Virus ◽

Hodgkin’S Disease ◽

Virus Genome ◽

Hiv Positive ◽

Barr Virus ◽

Epstein Barr

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Variant Chromatin Structure of theoriP Region of Epstein-Barr Virus and Regulation of EBER1 Expression by Upstream Sequences andoriP

Journal of Virology ◽

10.1128/jvi.75.13.6235-6241.2001 ◽

2001 ◽

Vol 75 (13) ◽

pp. 6235-6241 ◽

Cited By ~ 20

Author(s):

Barbara Wensing ◽

Albert Stühler ◽

Peter Jenkins ◽

Martine Hollyoake ◽

Claudio Elgueta Karstegl ◽

...

Keyword(s):

Epstein Barr Virus ◽

Virus Genome ◽

Micrococcal Nuclease ◽

Matrix Attachment Region ◽

Barr Virus ◽

Latently Infected ◽

Attachment Region ◽

Nuclear Matrix Attachment Region ◽

Epstein Barr ◽

Nucleosomal Structure

ABSTRACT Most of the Epstein-Barr virus genome in latently infected cells is in a standard nucleosomal structure, but the region encompassingoriP and the Epstein-Barr virus-encoded small RNA (EBER) genes shows a distinctive pattern when digested with micrococcal nuclease. This pattern corresponds to a previously mapped nuclear matrix attachment region. Although the EBER genes are adjacent to oriP, there is only a two- to fourfold effect oforiP on EBER expression. However, sequences containing a consensus ATF site upstream of EBER1 are important for EBER1 expression.

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Brief Communication Structure and Expression of the Epstein-Barr Virus Genome

Epstein-Barr Virus and Associated Diseases ◽

10.1007/978-1-4613-2625-0_26 ◽

1985 ◽

pp. 299-306

Author(s):

P. J. Farrell ◽

J. Dyson ◽

P. Tuffnell ◽

M. Biggin ◽

T. Gibson ◽

...

Keyword(s):

Epstein Barr Virus ◽

Virus Genome ◽

Communication Structure ◽

Barr Virus ◽

Epstein Barr

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Acyclovir Improves the Efficacy of Chemoradiation in Nasopharyngeal Cancer Containing the Epstein Barr Virus Genome

10.1101/2020.10.18.343236 ◽

2020 ◽

Author(s):

Aditya Thandoni ◽

Andrew Zloza ◽

Devora Schiff ◽

Malay Rao ◽

Kwok-wai Lo ◽

...

Keyword(s):

Epstein Barr Virus ◽

Treatment Options ◽

Immune Surveillance ◽

Nasopharyngeal Cancer ◽

Standard Of Care ◽

Virus Genome ◽

Barr Virus ◽

Standard Of Care Treatment ◽

Epstein Barr

AbstractNasopharyngeal carcinoma (NPC) is a malignancy endemic to East Asia and is caused by Epstein-Barr Virus (EBV)-mediated cancerous transformation of epithelial cells. The standard of care treatment for NPC involves radiation and chemotherapy. While treatment outcomes continue to improve, up to 50% of patients can be expected to recur by five years, and additional innovative treatment options are needed. We posit that a potential way to do this is by targeting the underlying cause of malignant transformation, namely EBV. One method by which EBV escapes immune surveillance is by undergoing latent phase replication, during which EBV expression of immunogenic proteins is reduced. However, chemoradiation is known to drive conversion of EBV from a latent to a lytic phase. This creates an opportunity for the targeting of EBV-infected cells utilizing anti-viral drugs. Indeed, we found that combining acyclovir with cisplatin and radiation significantly decreases the viability of the EBV-infected C666-1 cell line. Western blot quantification revealed a resultant increase of thymidine kinase (TK) and apoptosis-inducing mediators, cleaved PARP (cPARP) and phosphorylated ERK (pERK). These studies suggest that the addition of anti-viral drugs to frontline chemoradiation may improve outcomes in patients treated for EBV-related NPC and future in vivo and clinical studies are needed.

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