scholarly journals Nontransferrin-bound iron in plasma from hemochromatosis patients: effect of phlebotomy therapy

Blood ◽  
1988 ◽  
Vol 72 (4) ◽  
pp. 1416-1419 ◽  
Author(s):  
OI Aruoma ◽  
A Bomford ◽  
RJ Polson ◽  
B Halliwell
Keyword(s):  
Iron Overload ◽  
Binding Capacity ◽  
Radical Reactions ◽  
Iron Binding ◽  
Total Plasma ◽  
Free Radical Reactions ◽  
Low Concentrations ◽  
Idiopathic Hemochromatosis ◽  
Highly Correlated ◽  
Iron Binding Capacity

Abstract Plasma from patients with iron overload resulting from idiopathic hemochromatosis contains nontransferrin-bound iron, measurable by the bleomycin, assay. During venesection therapy, the concentration of bleomycin iron declines in a way highly correlated with plasma ferritin concentrations. Even when patients had been venesected to give very low total plasma iron concentrations and high transferrin iron-binding capacity, bleomycin-detectable iron was still present at low concentrations. Bleomycin-detectable iron can stimulate damaging free radical reactions, and its persistence in plasma even after prolonged venesection might contribute to the tissue damage that results from iron overload.

scholarly journals Nontransferrin-bound iron in plasma from hemochromatosis patients: effect of phlebotomy therapy

Blood ◽  
1988 ◽  
Vol 72 (4) ◽  
pp. 1416-1419 ◽  
Author(s):  
OI Aruoma ◽  
A Bomford ◽  
RJ Polson ◽  
B Halliwell
Keyword(s):  
Iron Overload ◽  
Binding Capacity ◽  
Radical Reactions ◽  
Iron Binding ◽  
Total Plasma ◽  
Free Radical Reactions ◽  
Low Concentrations ◽  
Idiopathic Hemochromatosis ◽  
Highly Correlated ◽  
Iron Binding Capacity

Plasma from patients with iron overload resulting from idiopathic hemochromatosis contains nontransferrin-bound iron, measurable by the bleomycin, assay. During venesection therapy, the concentration of bleomycin iron declines in a way highly correlated with plasma ferritin concentrations. Even when patients had been venesected to give very low total plasma iron concentrations and high transferrin iron-binding capacity, bleomycin-detectable iron was still present at low concentrations. Bleomycin-detectable iron can stimulate damaging free radical reactions, and its persistence in plasma even after prolonged venesection might contribute to the tissue damage that results from iron overload.

Elevated total iron-binding capacity as a predictor of response to deferasirox therapy in the setting of chronic iron overload

2014 ◽  
Vol 100 (3) ◽  
pp. 254-259 ◽  
Author(s):  
Junichi Watanabe ◽  
Ken Sato ◽  
Toshikatsu Horiuchi ◽  
Shoichiro Kato ◽  
Reina Hikota ◽  
...  
Keyword(s):  
Iron Overload ◽  
Binding Capacity ◽  
Total Iron ◽  
Iron Binding ◽  
Total Iron Binding Capacity ◽  
Iron Binding Capacity

PLASMA IRON AND IRON-BINDING CAPACITY

The Lancet ◽  
1975 ◽  
Vol 305 (7919) ◽  
pp. 1293
Author(s):  
Terry Hamblin
Keyword(s):  
Binding Capacity ◽  
Iron Binding ◽  
Plasma Iron ◽  
Iron Binding Capacity

Iron preparations for children

1966 ◽  
Vol 4 (3) ◽  
pp. 9-11
Keyword(s):  
Bone Marrow ◽  
Iron Deficiency ◽  
Blood Smear ◽  
Binding Capacity ◽  
Iron Binding ◽  
Iron Stores ◽  
Plasma Iron ◽  
Hypochromic Anaemia ◽  
Iron Binding Capacity

We have discussed iron preparations for adults in earlier articles;1 much of the information applies equally to children. Iron is not a ‘tonic’ and should be given only to prevent or correct iron deficiency. Estimation of the haemoglobin and inspection of a blood smear are the minimum investigations necessary before iron is prescribed in therapy. When deficiency is suspected in the absence of hypochromic anaemia, plasma iron and iron-binding capacity should be estimated and/or the bone marrow examined for haemosiderin crystals which disappear when iron stores are depleted.

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