Infant weight trajectories and early childhood wheezing: The NINFEA birth cohort study

Abstract Background Early childhood is a period when dietary behaviours are established. This study aimed to examine the longitudinal intake of core and discretionary foods and identify early life and socio-economic factors influencing those intakes. Methods Mother-infant dyads (n = 934) from the Healthy Smiles Healthy Kids study, an ongoing birth cohort study, were interviewed. The information on ‘weekly frequency of core and discretionary foods intake’ using a food frequency questionnaire was collected at 4 months, 8 months, 1 year, 2 years and 3 years age points. Group-based trajectory modelling analyses were performed to identify diet trajectories for ‘core’ and ‘discretionary’ foods respectively. A multinomial logistic regression was performed to identify the maternal and child-related predictors of resulting trajectories. Results The intake of core and discretionary foods each showed distinct quadratic (n = 3) trajectories with age. Overall, core foods intake increased rapidly in the first year of life, followed by a decline after age two, whereas discretionary foods intake increased steadily across the five age points. Multiparity (Relative Risk (RR): 0.46, 95%CI: 0.27–0.77), non-English speaking ethnicity of mother (RR: 0.66, 95%CI: 0.47–0.91) and having a single mother (RR: 0.40, 95%CI: 0.18–0.85) were associated with low trajectories of core foods intake whereas older maternal age (RR: 1.05, 95%CI: 1.01–1.08) and longer breastfeeding duration (RR: 1.02, 95%CI: 1.00–1.03) were associated with higher trajectories of core foods intake. Also, multiparity (RR 2.63, 95%CI: 1.47–4.70), low maternal education (RR 3.01, 95%CI: 1.61–5.65), and socio-economic disadvantage (RR 2.69, 95%CI: 1.31–5.55) were associated with high trajectories of discretionary foods intake. Conversely, longer duration of breastfeeding (RR 0.99, 95%CI: 0.97–0.99), and timely introduction of complementary foods (RR 0.30, 95%CI: 0.15–0.61) had a protective effect against high discretionary foods consumption in infancy and early childhood. Conclusion Children’s frequency of discretionary foods intake increases markedly as they transition from infancy to preschool age, and the trajectories of intake established during early childhood are strongly influenced by socio-demographic factors and infant feeding choices. Hence, there is a need for targeted strategies to improve nutrition in early childhood and ultimately prevent the incidence of chronic diseases in children.

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Wheezing and Bronchial Hyper-responsiveness in Early Childhood as Predictors of Newly Diagnosed Asthma in Early Adulthood: A Longitudinal Birth-Cohort Study

PEDIATRICS ◽

10.1542/peds.2009-1870eee ◽

2009 ◽

Vol 124 (Supplement 2) ◽

pp. S140.2-S141

Author(s):

Michael S. Kaplan

Keyword(s):

Early Childhood ◽

Cohort Study ◽

Birth Cohort ◽

Early Adulthood ◽

Birth Cohort Study ◽

Newly Diagnosed ◽

Bronchial Hyper Responsiveness

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Early Childhood Infectious Diseases and the Development of Asthma up to School Age: A Birth Cohort Study

PEDIATRICS ◽

10.1542/peds.110.s2.447a ◽

2002 ◽

Vol 110 (Supplement_2) ◽

pp. 447-448

Author(s):

Wanda Phipatanakul

Keyword(s):

Early Childhood ◽

Cohort Study ◽

Infectious Diseases ◽

Birth Cohort ◽

Birth Cohort Study ◽

School Age

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Identifying predictors of early childhood caries among Australian children using sequential modelling: Findings from the VicGen birth cohort study

Journal of Dentistry ◽

10.1016/j.jdent.2020.103276 ◽

2020 ◽

Vol 93 ◽

pp. 103276 ◽

Cited By ~ 1

Author(s):

Mark Gussy ◽

George Mnatzaganian ◽

Stuart Dashper ◽

Lauren Carpenter ◽

Hanny Calache ◽

...

Keyword(s):

Early Childhood ◽

Cohort Study ◽

Birth Cohort ◽

Early Childhood Caries ◽

Birth Cohort Study ◽

Childhood Caries

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4264 Early Childhood and Prepubertal Overweight and Obesity are Associated with Earlier Pubertal Onset in Boys and Girls: A Prospective Birth Cohort Study

Journal of Clinical and Translational Science ◽

10.1017/cts.2020.123 ◽

2020 ◽

Vol 4 (s1) ◽

pp. 28-28

Author(s):

Li-Kuang Chen ◽

Guoying Wang ◽

Wendy Bennett ◽

Xiaobin Wang

Keyword(s):

Early Childhood ◽

Birth Cohort ◽

Low Income ◽

Overweight And Obesity ◽

Height Velocity ◽

Birth Cohort Study ◽

Early Puberty ◽

Puberty Onset ◽

Weight Trajectories ◽

Prospective Birth Cohort

OBJECTIVES/GOALS: It is hypothesized that the global secular trend toward earlier puberty onset, with implications for many future health outcomes, is related to the obesity epidemic. This study aims to examine prospective associations between weight during specific developmental windows and timing of puberty onset. METHODS/STUDY POPULATION: This study includes 1,296 mother-infant dyads from the Boston Birth Cohort, a predominantly minority (>80% black/Hispanic), low-income, and urban prospective birth cohort recruited and followed between 1998 and 2019. Age at peak height velocity (APHV), a well-defined and standardized proxy for puberty onset, is derived by fitting height measurements recorded during clinical visits using a mixed effects growth curve model. Multiple linear regression is performed to examine the relationships between early childhood (ages 2-5y) and prepubertal (ages 6-9y) overweight and obesity, weight trajectories between these two periods, and APHV, while controlling for known contributors to early puberty. RESULTS/ANTICIPATED RESULTS: Compared to counterparts with normal BMIs, kids who were obese during ages 2-5y (boys: −0.21y, CI[−0.39, −0.04]; girls: −0.22y, CI[−0.39, −0.05]) or ages 6-9y (boys: −0.27y, CI[−0.43, −0.11]; girls: −0.37y, CI[−0.52, −0.23]) had an earlier APHV. Being overweight during ages 6-9y was also associated an earlier APHV (boys: −0.26y, CI[−0.46, −0.07]; girls: −0.26y, CI[−0.42, −0.10]). Looking at weight trajectories, kids who were persistently overweight or obese from ages 2-5y to ages 6-9y had an earlier APHV (boys: −0.28y, CI[−0.45, −0.12]; girls: −0.31y, CI[−0.46, −0.16]), as did girls with normal BMIs during ages 2-5y and who were overweight or obese during ages 6-9y (−0.45y CI[−0.64, −0.26]). DISCUSSION/SIGNIFICANCE OF IMPACT: The temporal and dose-response relationships seen in this historically understudied population suggests that childhood obesity is etiologically important in the development, and even programming, of early puberty. This has implications for prediction, prevention, and mitigation of health disparities.

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