Physical inactivity accentuates impairment of pulmonary mechanics in persistent moderate asthmatics: involvement of nitric oxide

2021 ◽  
Author(s):  
Renilson Moraes Ferreira ◽  
Maysa A R Brandao-Rangel ◽  
Anamei Silva-Reis ◽  
Thiago G Gibson-Alves ◽  
Helida C Aquino-Alves ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Physical Inactivity ◽  
Pulmonary Mechanics

scholarly journals Endothelial pulsatile shear stress is a backstop for COVID-19

2020 ◽  
Vol 4 (4) ◽  
pp. 391-399
Author(s):  
Marvin A. Sackner ◽  
Jose A. Adams
Keyword(s):  
Nitric Oxide ◽  
Shear Stress ◽  
Physical Inactivity ◽  
Muscular Activity ◽  
The Body ◽  
Diverse Populations ◽  
Extensive Investigation ◽  
Pulsatile Shear Stress

There has not been any means to inhibit replication of the SARS-CoV-2 virus responsible for the rapid, deadly spread of the COVID-19 pandemic and an effective, safe, tested across diverse populations vaccine still requires extensive investigation. This review deals with the repurpose of a wellness technology initially fabricated for combating physical inactivity by increasing muscular activity. Its action increases pulsatile shear stress (PSS) to the endothelium such that the bioavailability of nitric oxide (NO) and other mediators are increased throughout the body. In vitro evidence indicates that NO inhibits SARS-CoV-2 virus replication but there are no publications of NO delivery to the virus in vivo. It will be shown that increased PSS has potential in vivo to exert anti-viral properties of NO as well as to benefit endothelial manifestations of COVID-19 thereby serving as a safe and effective backstop.

scholarly journals Acute hypoxia and reoxygenation impairs exhaled nitric oxide release and pulmonary mechanics

2000 ◽  
Vol 119 (5) ◽  
pp. 931-938 ◽  
Author(s):  
Jeffrey M. Pearl ◽  
David P. Nelson ◽  
Scott A. Wellmann ◽  
Jenni L. Raake ◽  
Connie J. Wagner ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Acute Hypoxia ◽  
Exhaled Nitric Oxide ◽  
Pulmonary Mechanics ◽  
Nitric Oxide Release

Localization of endothelial nitric oxide synthase in the normal and failing human atrial myocardium

1996 ◽  
Vol 54 ◽  
pp. 786-787
Author(s):  
Chi-Ming Wei ◽  
Margarita Bracamonte ◽  
Shi-Wen Jiang ◽  
Richard C. Daly ◽  
Christopher G.A. McGregor ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Heart Failure ◽  
Nitric Oxide Synthase ◽  
Endothelial Nitric Oxide Synthase ◽  
Cardiac Tissues ◽  
Mammalian Tissues ◽  
End Stage Heart Failure ◽  
End Stage ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide

Nitric oxide (NO) is a potent endothelium-derived relaxing factor which also may modulate cardiomyocyte inotropism and growth via increasing cGMP. While endothelial nitric oxide synthase (eNOS) isoforms have been detected in non-human mammalian tissues, expression and localization of eNOS in the normal and failing human myocardium are poorly defined. Therefore, the present study was designed to investigate eNOS in human cardiac tissues in the presence and absence of congestive heart failure (CHF).Normal and failing atrial tissue were obtained from six cardiac donors and six end-stage heart failure patients undergoing primary cardiac transplantation. ENOS protein expression and localization was investigated utilizing Western blot analysis and immunohistochemical staining with the polyclonal rabbit antibody to eNOS (Transduction Laboratories, Lexington, Kentucky).

Nitric Oxide Reduces Pressor Responsiveness During Ovine Hypoadrenocorticism

2001 ◽  
Vol 28 (5-6) ◽  
pp. 459-462
Author(s):  
Pini Orbach ◽  
Charles E Wood ◽  
Maureen Keller-Wood
Keyword(s):  
Nitric Oxide
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