Clinical comparability between the CFC and HFA budesonide pressurised metered-dose inhalers in paediatric patients with asthma: a randomised controlled trial

2006 ◽  
Vol 22 (6) ◽  
pp. 1085-1092 ◽  
Author(s):  
A. Escribano ◽  
A. Tutuncu ◽  
I. Löhr ◽  
M. Carlholm ◽  
T. Polanowski
Keyword(s):  
Randomised Controlled Trial ◽  
Controlled Trial ◽  
Metered Dose Inhalers ◽  
Paediatric Patients ◽  
Metered Dose ◽  
Randomised Controlled ◽  
Clinical Comparability ◽  
Pressurised Metered Dose Inhalers

scholarly journals Protocol of a randomised controlled trial assessing the impact of physical activity on bone health in children with inflammatory bowel disease

BMJ Open ◽  
2020 ◽  
Vol 10 (5) ◽  
pp. e036400
Author(s):  
Jérémy Vanhelst ◽  
Stéphanie Coopman ◽  
Julien Labreuche ◽  
Claire Dupont ◽  
Valérie Bertrand ◽  
...  
Keyword(s):  
Physical Activity ◽  
Inflammatory Bowel Disease ◽  
Randomised Controlled Trial ◽  
Bone Health ◽  
Bowel Disease ◽  
Controlled Trial ◽  
Whole Body ◽  
Paediatric Patients ◽  
Inflammatory Bowel ◽  
Randomised Controlled

IntroductionLow bone mineral density (BMD) is a frequent issue in children and adolescents with inflammatory bowel disease (IBD). Several studies in healthy populations have reported a positive impact of physical activity (PA) on bone health. Recently, an observational study in paediatric patients with IBD showed a significant positive relationship between daily PA and BMD. However, intervention studies investigating a causal relationship between PA and BMD are warranted to confirm these results. The aim of this randomised controlled trial will be to investigate the effect of a PA programme on BMD in paediatric patients with IBD.Methods and analysisThis trial is a multicentre (four centres), randomised, controlled, blinded end-point study. Eighty children with IBD will be randomly assigned in a 1:1 ratio to receive a programme with adapted physical exercises (intervention group) or usual PA (control group) during a 9-month period. The primary outcome is the change from baseline at 9 months (the end of the study) in whole-body BMD assessed by dual-energy X-ray absorptiometry. Secondary efficacy outcomes include the changes from baseline at 9 months in: BMD assessed in the lumbar spine and trochanter; daily PA (time spent in moderate-to-vigorous PA); body composition (fat mass and fat-free mass); fatigue resistance; quality of life and activity of IBD.Ethics and disseminationThe study was approved by the Research Ethics Committee in France (Comité de Protection des Personnes, Sud-Ouest and Outre-Mer III, Bordeaux, France, No 2018/27). All procedures will be performed according to the ethical standards of the Helsinki Declaration of 1975, as revised in 2008, and the European Union’s Guidelines for Good Clinical Practice. Written informed consent will be obtained from the parents or legal guardian and from the children. Research findings will be disseminated in peer-reviewed journals and scientific meetings.Trial registration numberNCT03774329.

scholarly journals Small lateral access—an alternative approach to appendicitis in paediatric patients: A randomised controlled trial

2007 ◽  
Vol 5 (4) ◽  
pp. 234-238 ◽  
Author(s):  
Arshad Hussain Malik ◽  
R.A. Wani ◽  
B.D. Saima ◽  
M.Y. Wani
Keyword(s):  
Randomised Controlled Trial ◽  
Controlled Trial ◽  
Paediatric Patients ◽  
Alternative Approach ◽  
Randomised Controlled

scholarly journals The CLOSED trial; CLOnidine compared with midazolam for SEDation of paediatric patients in the intensive care unit: study protocol for a multicentre randomised controlled trial

BMJ Open ◽  
2017 ◽  
Vol 7 (6) ◽  
pp. e016031 ◽  
Author(s):  
Antje Neubert ◽  
Manuel Alberto Baarslag ◽  
Monique van Dijk ◽  
Joost van Rosmalen ◽  
Joseph F Standing ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Randomised Controlled Trial ◽  
Study Protocol ◽  
Controlled Trial ◽  
Paediatric Patients ◽  
Randomised Controlled

Metered-dose inhaler ipratropium bromide in moderate acute asthma in children: A single-blinded randomised controlled trial

2014 ◽  
Vol 51 (2) ◽  
pp. 192-198 ◽  
Author(s):  
Emma L Wyatt ◽  
Meredith L Borland ◽  
Sarah K Doyle ◽  
Gary C Geelhoed
Keyword(s):  
Randomised Controlled Trial ◽  
Ipratropium Bromide ◽  
Acute Asthma ◽  
Controlled Trial ◽  
Dose Inhaler ◽  
Metered Dose Inhaler ◽  
Metered Dose ◽  
Asthma In Children ◽  
Randomised Controlled

scholarly journals Effect of regular alveolar recruitment on intraoperative atelectasis in paediatric patients ventilated in the prone position: a randomised controlled trial

2020 ◽  
Vol 124 (5) ◽  
pp. 648-655
Author(s):  
Young-Eun Jang ◽  
Sang-Hwan Ji ◽  
Eun-Hee Kim ◽  
Ji-Hyun Lee ◽  
Jin-Tae Kim ◽  
...  
Keyword(s):  
Randomised Controlled Trial ◽  
Prone Position ◽  
Controlled Trial ◽  
Alveolar Recruitment ◽  
Paediatric Patients ◽  
Randomised Controlled
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