Prevalence and risk factors for chronic kidney disease in patients with coronary artery disease

We aim to evaluate the development of peripheral occlusive artery disease (PAOD) in patients with migraine by using the National Health Insurance Research Database in Taiwan. A retrospective cohort study was conducted and individuals with diagnostic codes of migraine were enrolled in the study group after excluding those diagnosed with PAOD before the index date. Each subject with migraine was propensity-score matched to another non-migraine patient and the latter served as the control group. A total of 37,288 patients were finally enrolled in the groups. The primary outcome was set as the development of PAOD between the two groups while multiple possible risk factors, including demographic data and comorbidities, were analyzed via the Cox proportional hazards regression. There were 885 and 530 PAOD events in the study and control groups, and the study group had a significantly higher adjusted hazard ratio (1.65, 95% confidential interval: 1.48–1.84, p < 0.001), and the cumulative incidence also revealed a correlation between migraine and PAOD. Other potential risk factors related to the existence of PAOD include age, hypertension, chronic kidney disease, diabetes mellitus, coronary artery disease, stroke, and asthma. For individuals without certain systemic diseases including hypertension, chronic liver disease, chronic kidney disease, coronary artery disease, stroke, asthma, or heart failure, the hazard ratio of subsequent PAOD was significantly higher in the migraine patients than that in the non-migraine individuals (all p < 0.001). In conclusion, the presence of migraine is a significant risk factor for the development of subsequent PAOD.

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Abstract: 1036 EFFECT OF CONVENTIONAL RISK FACTORS ON THE PRESENCE OF CORONARY ARTERY DISEASE AS ASSESSED BY 64-MDCT IN PATIENTS WITH LOW-STAGE CHRONIC KIDNEY DISEASE

Atherosclerosis Supplements ◽

10.1016/s1567-5688(09)70390-3 ◽

2009 ◽

Vol 10 (2) ◽

pp. e398

Author(s):

R Mitsutake ◽

S-I Miura ◽

Y Shiga ◽

K Saku

Keyword(s):

Risk Factors ◽

Coronary Artery Disease ◽

Chronic Kidney Disease ◽

Coronary Artery ◽

Kidney Disease ◽

Artery Disease ◽

Conventional Risk Factors

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Chronic Kidney Disease Has a Graded Association with Death and Cardiovascular Outcomes in Stable Coronary Artery Disease: An Analysis of 21,911 Patients from the CLARIFY Registry

Journal of Clinical Medicine ◽

10.3390/jcm9010004 ◽

2019 ◽

Vol 9 (1) ◽

pp. 4

Author(s):

Emmanuelle Vidal-Petiot ◽

Nicola Greenlaw ◽

Paul R. Kalra ◽

Xavier Garcia-Moll ◽

Jean-Claude Tardif ◽

...

Keyword(s):

Risk Factors ◽

Coronary Artery Disease ◽

Chronic Kidney Disease ◽

Renal Function ◽

Coronary Artery ◽

Kidney Disease ◽

Cardiovascular Mortality ◽

Stable Coronary Artery Disease ◽

Ckd Stage ◽

Artery Disease

Chronic kidney disease (CKD) is associated with an increased cardiovascular risk in a broad spectrum of populations. However, the risk associated with a reduced estimated glomerular filtration rate (eGFR) in patients with stable coronary artery disease receiving standard care in the modern era, independently of baseline cardiovascular disease, risk factors, and comorbidities, remains unclear. We analyzed data from 21,911 patients with stable coronary artery disease, enrolled in 45 countries between November 2009 and July 2010 in the CLARIFY registry. Patients with abnormal renal function were older, with more comorbidities, and received slightly lower—although overall high—rates of evidence-based secondary prevention therapies than patients with normal renal function. The event rate of patients with CKD stage 3b or more (eGFR <45 mL/min/1.73 m2) was much higher than that associated with any comorbid condition. In a multivariable adjusted Cox proportional hazards model, lower eGFR was independently associated with a graded increased risk of cardiovascular mortality, with adjusted HRs (95% CI) of 0.98 (0.81–1.18), 1.31 (1.05–1.63), 1.77 (1.38–2.27), and 3.12 (2.25–4.33) for eGFR 60–89, 45–59, 30–44, and <30 mL/min/1.73 m2, compared with eGFR ≥90 mL/min/1.73 m2. A strong graded independent relationship exists between the degree of CKD and cardiovascular mortality in this large cohort of patients with chronic coronary artery disease, despite high rates of secondary prevention therapies. Among clinical risk factors and comorbid conditions, CKD stage 3b or more is associated with the highest cardiovascular mortality.

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