scholarly journals Migraine as a Risk Factor for Peripheral Artery Occlusive Disease: A Population-Based Cohort Study

Author(s):  
Fu-Hsuan Kuo ◽  
Chia-Yi Lee ◽  
Ju-Pi Li ◽  
Jui-Fu Chung ◽  
Yu-Hsun Wang ◽  
...  

We aim to evaluate the development of peripheral occlusive artery disease (PAOD) in patients with migraine by using the National Health Insurance Research Database in Taiwan. A retrospective cohort study was conducted and individuals with diagnostic codes of migraine were enrolled in the study group after excluding those diagnosed with PAOD before the index date. Each subject with migraine was propensity-score matched to another non-migraine patient and the latter served as the control group. A total of 37,288 patients were finally enrolled in the groups. The primary outcome was set as the development of PAOD between the two groups while multiple possible risk factors, including demographic data and comorbidities, were analyzed via the Cox proportional hazards regression. There were 885 and 530 PAOD events in the study and control groups, and the study group had a significantly higher adjusted hazard ratio (1.65, 95% confidential interval: 1.48–1.84, p < 0.001), and the cumulative incidence also revealed a correlation between migraine and PAOD. Other potential risk factors related to the existence of PAOD include age, hypertension, chronic kidney disease, diabetes mellitus, coronary artery disease, stroke, and asthma. For individuals without certain systemic diseases including hypertension, chronic liver disease, chronic kidney disease, coronary artery disease, stroke, asthma, or heart failure, the hazard ratio of subsequent PAOD was significantly higher in the migraine patients than that in the non-migraine individuals (all p < 0.001). In conclusion, the presence of migraine is a significant risk factor for the development of subsequent PAOD.

2012 ◽  
Vol 28 (3) ◽  
pp. 379-384 ◽  
Author(s):  
Yu-Shi Bao ◽  
Shi-Ping Na ◽  
Xi-Bei Jia ◽  
Rui-Chan Liu ◽  
Ming-Ao Wang ◽  
...  

2007 ◽  
Vol 28 (2) ◽  
pp. 317-323 ◽  
Author(s):  
Ming-Chia Hsieh ◽  
Jeng-Yueh Hsiao ◽  
Kai-Jen Tien ◽  
Shun-Jen Chang ◽  
Shih-Chieh Hsu ◽  
...  

2012 ◽  
Vol 19 (05) ◽  
pp. 604-610
Author(s):  
ABDUL HAMEED CHOHEDRI ◽  
MANSOUR MASJEDI ◽  
MOHAMMAD HOSSEIN EGHBAL

Background : Knowledge about coronary artery disease and it’s risk factors is a very important factor in prevention of ischemicheart disease. The aim of this study was to investigate knowledge of patient attendants about coronary artery disease and its risk factors insouthern of Iran; Shiraz. Design: Cross sectional study. Setting: Shiraz University of Medical Sciences. Materials and Methods: 800 patientattendants (persons accompanying patients) selected randomly and divided into two groups (study and control) each including 400 patientattendants. Face to face interview was done and knowledge was measured by correct answers to our standard questionnaire. Results: Themedian knowledge score was 6.89 for study group and was 2.82 for control group out of a possible maximum of 15. Majority of respondents instudy group could identify up to three risk factors for coronary artery disease, but in control group could identify only one risk factor. About 5.8%in study group and 37.5% in control group were not able to identify even a single risk factor for coronary artery disease. Conclusions:According to our results there is a big gap in knowledge about coronary artery disease and it’s risk factors in our population. It means that moreeducational programs are needed to prevent the increasing rate of coronary artery disease.


2019 ◽  
Vol 9 (1) ◽  
pp. 4
Author(s):  
Emmanuelle Vidal-Petiot ◽  
Nicola Greenlaw ◽  
Paul R. Kalra ◽  
Xavier Garcia-Moll ◽  
Jean-Claude Tardif ◽  
...  

Chronic kidney disease (CKD) is associated with an increased cardiovascular risk in a broad spectrum of populations. However, the risk associated with a reduced estimated glomerular filtration rate (eGFR) in patients with stable coronary artery disease receiving standard care in the modern era, independently of baseline cardiovascular disease, risk factors, and comorbidities, remains unclear. We analyzed data from 21,911 patients with stable coronary artery disease, enrolled in 45 countries between November 2009 and July 2010 in the CLARIFY registry. Patients with abnormal renal function were older, with more comorbidities, and received slightly lower—although overall high—rates of evidence-based secondary prevention therapies than patients with normal renal function. The event rate of patients with CKD stage 3b or more (eGFR <45 mL/min/1.73 m2) was much higher than that associated with any comorbid condition. In a multivariable adjusted Cox proportional hazards model, lower eGFR was independently associated with a graded increased risk of cardiovascular mortality, with adjusted HRs (95% CI) of 0.98 (0.81–1.18), 1.31 (1.05–1.63), 1.77 (1.38–2.27), and 3.12 (2.25–4.33) for eGFR 60–89, 45–59, 30–44, and <30 mL/min/1.73 m2, compared with eGFR ≥90 mL/min/1.73 m2. A strong graded independent relationship exists between the degree of CKD and cardiovascular mortality in this large cohort of patients with chronic coronary artery disease, despite high rates of secondary prevention therapies. Among clinical risk factors and comorbid conditions, CKD stage 3b or more is associated with the highest cardiovascular mortality.


2019 ◽  
Vol 8 (5) ◽  
pp. 677-685
Author(s):  
Til Bahadur Basnet ◽  
Cheng Xu ◽  
Manthar Ali Mallah ◽  
Wiwik Indayati ◽  
Cheng Shi ◽  
...  

Abstract There are well-known traditional risk factors for coronary artery disease (CAD). Among them, smoking is one of the most prominent and modifiable risk factors. This study aims to determine the magnitude of smoking as a risk factor for CAD in the Nepalese population. A hospital-based age- and sex-matched case–control study was carried out with a total of 612 respondents. Bivariate analysis showed that the risk of developing CAD in ex-smokers and current smokers was higher (odds ratio (OR): 1.81 (confidence interval (CI): 1.21–2.7) and OR: 5.2 (CI: 3.4–7.97)), with p-values less than 0.004 and &lt;0.00001, respectively, compared to the risk in never smokers. From stratified socio-demographic, cardio-metabolic, behavioural and psychosocial risk factor analysis, smoking was found to be associated with CAD in almost all subgroups. In the subsequent multivariate analysis, adjustment for socio-demographic, cardio-metabolic and psychosocial risk factors showed a steady increase in risk. However, further adjustment for behavioural risk factors (alcohol use and physical activity) showed that the risk was attenuated by 59% in current smokers. After adjusting for the covariates, current smokers and ex-smokers had an increased risk of CAD (OR: 6.64, 95% CI: 3.64–12.12, p &lt; 0.00001; OR: 1.89, 95% CI: 1.08–3.31, p &lt; 0.012, respectively) compared with non-smokers. In conclusion, smoking was found to increase the risk of CAD in the Nepalese population.


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