Six-month pilot study of oestrogen replacement therapy with piperazine oestrone sulphate and its effect on memory

1977 ◽  
Vol 4 (sup3) ◽  
pp. 21-28 ◽  
Author(s):  
B. W. Hackman ◽  
D. Galbraith
BMJ ◽  
1992 ◽  
Vol 305 (6862) ◽  
pp. 1161-1161
Author(s):  
A. Clarke ◽  
N. Black ◽  
P. Rowe

Critical Care ◽  
2008 ◽  
Vol 12 (4) ◽  
pp. R111 ◽  
Author(s):  
Andreas Link ◽  
Matthias Girndt ◽  
Simina Selejan ◽  
Ranja Rbah ◽  
Michael Böhm

1979 ◽  
Vol 83 (1) ◽  
pp. 67-77 ◽  
Author(s):  
LUCIENNE PAPADAKI ◽  
J. O. W. BEILBY ◽  
JANINA CHOWANIEC ◽  
W. F. COULSON ◽  
A. J. DARBY ◽  
...  

SUMMARY Female CBA mice, aged 11 months, were treated cyclically with oral ethynyl oestradiol or oestrone sulphate for 3 months. The ovaries of all animals appeared to be atrophied. Target tissues throughout the genital tract showed a response to both oestrogens. Electron microscopy of both the endometrium and the urothelium demonstrated morphological changes characteristic of increased cellular metabolic activity in the treated mice. Endometrial hyperplasia developed in both treatment groups but more pronounced epithelial changes occurred with oestrone sulphate. This hyperplasia was accompanied by a doubling in the number of uterine cytoplasmic oestrogen receptors. A 50% fall in serum levels of luteinizing hormone in the treated mice revealed that the hypothalamic-pituitary system was still intact. Both oestrogens improved skeletal balance by changes in cortical-endosteal bone remodelling. The results suggest that the CBA strain of mouse is a suitable model for the study of the human climacteric and its response to hormone replacement therapy.


2020 ◽  
Author(s):  
Jaimee L Heffner ◽  
Sheryl L Catz ◽  
Predrag Klasnja ◽  
Brooks Tiffany ◽  
Jennifer B McClure

BACKGROUND The majority of cigarette smokers want to quit someday but are not ready to commit to long-term abstinence. However, available smoking cessation treatments are not well-suited to meet the needs of these ambivalent smokers. Low-cost, high-reach mobile health (mHealth) interventions may be a cost-efficient means of offering assistance to ambivalent smokers, yet there are currently no evidence-based options available for this group. OBJECTIVE The aim of this study was to develop and preliminarily evaluate the core content for an mHealth program targeting adult smokers who are ambivalent about quitting. The core content consisted of a series of “personal experiments” similar to those tested as part of a counseling intervention in prior work, including brief cognitive or behavioral tasks designed to boost readiness for changing smoking behavior. METHODS We conducted individual user interviews (N=3) to refine program content, and then conducted a one-arm pilot study (N=25) to assess user receptivity and the potential impact of the experiments on motivation and self-efficacy to quit or reduce smoking. RESULTS In user interviews, participants liked the concept of the personal experiments. Participants in the pilot study found a medium-fidelity prototype to be highly acceptable. After watching a brief orientation video that explained how the program works, most participants (80%, 20/25) indicated that it sounded interesting, primarily because it did not require any commitment to quit. All participants (100%, 25/25) completed all 7 experiments, including a 24-hour quit attempt, although not all were able to refrain from smoking for a full day based on qualitative feedback on the experiment. The mean rating of usefulness of the overall program was 4.12 (SD 1.09) out of 5, and the average rating of the difficulty of the experiments was 2.16 (SD 1.18) out of 5. At the last assessment point, 92% (23/25) of the participants indicated that they were more interested in either quitting or cutting back than when they began the program, and 72% (18/25) said that if the program had included a free trial of nicotine replacement therapy, they would have used it to try to quit smoking. CONCLUSIONS This formative work confirmed that ambivalent smokers are willing to use and will remain engaged with an mHealth intervention that employs the novel concept of personal experiments to enhance their motivation for and ability to quit smoking. The addition of action-oriented treatment (self-help and free nicotine replacement therapy, quitline referral) could further support users’ efforts to stop smoking and remain quit.


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