scholarly journals Intranasal immunization with plasmid DNA encoding spike protein of SARS-coronavirus/polyethylenimine nanoparticles elicits antigen-specific humoral and cellular immune responses

2010 ◽  
Vol 11 (1) ◽  
pp. 65 ◽  
Author(s):  
Byoung-Shik Shim ◽  
Sung-Moo Park ◽  
Ji-Shan Quan ◽  
Dhananjay Jere ◽  
Hyuk Chu ◽  
...  
Keyword(s):  
Immune Responses ◽  
Plasmid Dna ◽  
Spike Protein ◽  
Dna Encoding ◽  
Sars Coronavirus ◽  
Intranasal Immunization ◽  
Cellular Immune Responses ◽  
Cellular Immune

scholarly journals Marked Enhancement of the Antigen-Specific Immune Response by Combining Plasmid DNA-Based Immunization with a Schiff Base-Forming Drug

2002 ◽  
Vol 70 (12) ◽  
pp. 6652-6657 ◽  
Author(s):  
Jehad Charo ◽  
Maria Sundbäck ◽  
Ken Wasserman ◽  
Anne-Marie T. Ciupitu ◽  
Babak Mirzai ◽  
...  
Keyword(s):  
Immune Response ◽  
Schiff Base ◽  
Immune Responses ◽  
Plasmid Dna ◽  
Cellular Immune Responses ◽  
Low Concentrations ◽  
Proven Efficacy ◽  
Significant Augmentation ◽  
Cellular Immune ◽  
Further Development

ABSTRACT Although plasmid DNA (pDNA)-based immunization has proven efficacy, the level of immune responses that is achieved by this route of vaccination is often lower than that induced by traditional vaccines, especially for primates and humans. We report here a simple and potent method to enhance pDNA-based vaccination by using two different plasmids encoding viral or bacterial antigens. This method is based on coadministration of low concentrations of a recently described immunopotentiating, Schiff base-forming drug called tucaresol which has led to significant augmentation of antigen-specific humoral and cellular immune responses. Our data suggest that enhancement of the immune response with tucaresol might provide a powerful tool for the further development of pDNA-based immunization for humans.

scholarly journals Plasmid DNA Vaccine-Elicited Cellular Immune Responses Limit In Vivo Vaccine Antigen Expression through Fas-Mediated Apoptosis

2007 ◽  
Vol 178 (9) ◽  
pp. 5652-5658 ◽  
Author(s):  
John R. Greenland ◽  
Ralf Geiben ◽  
Sharmistha Ghosh ◽  
William A. Pastor ◽  
Norman L. Letvin
Keyword(s):  
Immune Responses ◽  
Dna Vaccine ◽  
Plasmid Dna ◽  
Antigen Expression ◽  
Vaccine Antigen ◽  
Cellular Immune Responses ◽  
Plasmid Dna Vaccine ◽  
Cellular Immune

scholarly journals Induction of neutralising antibodies and cellular immune responses against SARS coronavirus by recombinant measles viruses

Vaccine ◽  
2008 ◽  
Vol 26 (17) ◽  
pp. 2164-2174 ◽  
Author(s):  
Matthias Liniger ◽  
Armando Zuniga ◽  
Azaibi Tamin ◽  
Teldja N. Azzouz-Morin ◽  
Marlyse Knuchel ◽  
...  
Keyword(s):  
Immune Responses ◽  
Sars Coronavirus ◽  
Neutralising Antibodies ◽  
Cellular Immune Responses ◽  
Cellular Immune
Sign in / Sign up

Export Citation Format

Share Document